ATP-Dependent Chromatin Remodeler CSB Couples DNA Repair Pathways to Transcription with Implications for Cockayne Syndrome and Cancer Therapy DOI Creative Commons
Rabeya Bilkis, Robert J. Lake, Hua-Ying Fan

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 239 - 239

Published: Feb. 7, 2025

Efficient DNA lesion repair is crucial for cell survival, especially within actively transcribed regions that contain essential genetic information. Additionally, breaks in of active transcription are prone to generating insertions and deletions, which hallmark features cancer genomes. Cockayne syndrome protein B (CSB) the sole ATP-dependent chromatin remodeler coupling pathways with transcription, leading more efficient transcription. CSB best known its function transcription-coupled nucleotide excision (TC-NER), a process rapidly removes helix-distorting lesions stall RNA polymerase II, such as those created by chemotherapeutic platinum compounds UV irradiation. In addition NER, has also been reported couple homologous recombination Most recently, shown single-strand break this review, we will discuss overlapping distinct mechanisms couples these different We how functions may account emerging roles an innovative target therapy.

Language: Английский

Transcription: friend or foe of genome stability DOI
Emmanuel Compe, Donata Orioli

FEBS Letters, Journal Year: 2025, Volume and Issue: 599(2), P. 143 - 146

Published: Jan. 1, 2025

Language: Английский

Citations

0
ATP-Dependent Chromatin Remodeler CSB Couples DNA Repair Pathways to Transcription with Implications for Cockayne Syndrome and Cancer Therapy DOI Creative Commons
Rabeya Bilkis, Robert J. Lake, Hua-Ying Fan

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 239 - 239

Published: Feb. 7, 2025

Efficient DNA lesion repair is crucial for cell survival, especially within actively transcribed regions that contain essential genetic information. Additionally, breaks in of active transcription are prone to generating insertions and deletions, which hallmark features cancer genomes. Cockayne syndrome protein B (CSB) the sole ATP-dependent chromatin remodeler coupling pathways with transcription, leading more efficient transcription. CSB best known its function transcription-coupled nucleotide excision (TC-NER), a process rapidly removes helix-distorting lesions stall RNA polymerase II, such as those created by chemotherapeutic platinum compounds UV irradiation. In addition NER, has also been reported couple homologous recombination Most recently, shown single-strand break this review, we will discuss overlapping distinct mechanisms couples these different We how functions may account emerging roles an innovative target therapy.

Language: Английский

Citations

0