Cancer-Associated Fibroblasts as the “Architect” of the Lung Cancer Immune Microenvironment: Multidimensional Roles and Synergistic Regulation with Radiotherapy DOI Open Access
Zheng Shi,

Cuilan Hu,

Huijuan Li

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3234 - 3234

Published: March 31, 2025

Cancer-associated fibroblasts (CAFs), as the “architect” of immune microenvironment in lung cancer, play a multidimensional role tumor progression and regulation. In this review, we summarize heterogeneity origin molecular phenotype CAFs explore complex interactions between multiple components microenvironment, including regulatory relationships with innate cells (e.g., tumor-associated macrophages, neutrophils), adaptive T cells), extracellular matrix (ECM). significantly influence immunomodulation through secretion cytokines, remodeling ECM, regulation cell function affects escape treatment resistance tumors. addition, review also deeply explored synergistic relationship CAF radiotherapy, revealing key radiotherapy-induced which provides new perspective for optimizing comprehensive strategy cancer. By comprehensively analyzing roles its interaction aims to provide theoretical basis precise clinical

Language: Английский

Cancer-Associated Fibroblasts as the “Architect” of the Lung Cancer Immune Microenvironment: Multidimensional Roles and Synergistic Regulation with Radiotherapy DOI Open Access
Zheng Shi,

Cuilan Hu,

Huijuan Li

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3234 - 3234

Published: March 31, 2025

Cancer-associated fibroblasts (CAFs), as the “architect” of immune microenvironment in lung cancer, play a multidimensional role tumor progression and regulation. In this review, we summarize heterogeneity origin molecular phenotype CAFs explore complex interactions between multiple components microenvironment, including regulatory relationships with innate cells (e.g., tumor-associated macrophages, neutrophils), adaptive T cells), extracellular matrix (ECM). significantly influence immunomodulation through secretion cytokines, remodeling ECM, regulation cell function affects escape treatment resistance tumors. addition, review also deeply explored synergistic relationship CAF radiotherapy, revealing key radiotherapy-induced which provides new perspective for optimizing comprehensive strategy cancer. By comprehensively analyzing roles its interaction aims to provide theoretical basis precise clinical

Language: Английский

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