Reactive Oxygen Species in Neurodegenerative Disorders DOI
Arushi Sharma,

Smriti Tiwari,

Himanshu Sharma

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2025, Volume and Issue: unknown, P. 411 - 440

Published: Jan. 3, 2025

Reactive oxygen species (ROS) are chemically reactive molecules containing oxygen. In the context of neurodegenerative disorders, ROS play a dual role while they necessary for normal cellular function, their overproduction can lead to oxidative stress, damaging neurons and contributing pathogenesis diseases such as Alzheimer's, Parkinson's, Huntington's, Amyotrophic Lateral Sclerosis (ALS). This book chapter explores mechanisms by which contributes neurodegeneration, including mitochondrial dysfunction, protein aggregation, inflammation. Additionally, we discuss current emerging therapeutic strategies aimed at modulating levels mitigating damage, antioxidants, gene therapy, lifestyle interventions. Understanding balance between production antioxidant defenses is crucial developing effective treatments diseases.

Language: Английский

A simple, cost-efficient stability-indicating RP-HPLC method for simultaneous estimation of embelin and piperine for routine analysis of marketed polyherbal capsules and tablets DOI
Aparna Inamdar, Mahesh Palled, Shailendra S. Suryawanshi

et al.

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: Jan. 9, 2025

Embelin (EMB) and Piperine (PIP) alkaloids are reported for ­antidiabetic, hypolipidemic, antioxidant, anti-cancer properties. However, simultaneous analytical methods scarce. A stability-indicating RP-HPLC method was developed with mobile phase MeOH: 0.1%TEA (pH 4.2 adjusted by OPA) (92:08 v/v ratio), CHEMSIL-ODS, C18 (4.6 × 250mm, 5 µm) column, 1.2 mL/min ­flowrate. Retention times were 3.2, 6.2 min PIP EMB respectively, at 289 nm, validated as per Q2 (R1) ICH guidelines. Linearity ranging (2-10 µg/mL), regression coefficients (r2), LOD, LOQ r2 = 0.9979, 0.793 µg/mL, 2.403 0.9974, 0.851 2.578 µg/mL EMB. Developed precision, robustness, ruggedness confirmed <2%RSD. In tablet capsule formulations, %purity 90.36%, 94.33%, 91.65, 92.85%. Additionally, forced-degradation studies ­indicated stability through various stressed conditions. Hence, this ­validated is specific, precise, linear, accurate, robust, ­suitable routine analysis of in polyherbal ­formulations containing Embelia ribes Brum. Piper nigrum Linn. extracts.

Language: Английский

Citations

1
Encapsulation of berry bioactives DOI
Faten Raboudi,

Fethi Ben Slama,

Luana Bontempo

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 209 - 239

Published: Jan. 1, 2025

Language: Английский

Citations

0
Decoding Xanthine Derivatives: Advanced Analytical, Extraction, and Quantification Techniques in Pharma and Biofluids – A Comprehensive Review DOI

N. R. Soundaryashree,

Sinchana B Gopalaiah,

Aparna Inamdar

et al.

Critical Reviews in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: April 10, 2025

Xanthine derivatives, such as bamifylline hydrochloride (BMFH), theophylline (THP), aminophylline (AMI), and diprophylline (DPH), are potent adenosine-receptor antagonists widely used in managing respiratory disorders like chronic obstructive pulmonary disease, asthma, cardiac asthma due to their cardiovascular diuretic properties. Despite clinical utility, the complexity of bioanalysis limited advancements analytical methodologies exhibit challenges broader application. This review evaluates advanced analytical, extraction, quantification techniques for selected xanthine emphasizing applicability pharmaceutical biofluid matrices. A comprehensive was conducted using databases Scopus, PubMed, Web Science, ScienceDirect, utilizing keywords UV-visible spectrophotometric, chromatographic (high-performance liquid chromatography [HPLC], high-performance thin-layer [HPTLC]), hyphenated (liquid chromatography-mass spectrometry [LC-MS]) techniques. detailed analysis extraction methods, including solid-phase (SPE), liquid-liquid (LLE), protein precipitation (PPE), included. The findings demonstrate that HPLC, often combined with SPE, offers superior sensitivity specificity quantifying derivatives. BMFH is effectively analyzed HPLC methanol (MeOH)-ammonium acetate mobile phases, achieving limits detection <2 ng/mL. THP exhibits broad treatments, spectroscopy being its quantification. However, data bioanalytical techniques, particularly AMI DPH, highlights need further development. Hyphenated provide significant advantages pharmacokinetic studies but remain underutilized xanthines. refines methods derivatives enhance research applications. Future directions include developing high-throughput, automated expanding profiling underexplored AMI.

Language: Английский

Citations

0
Prunin: An Emerging Anticancer Flavonoid DOI Open Access
Juie Nahushkumar Rana, Sohail Mumtaz

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2678 - 2678

Published: March 16, 2025

Despite the substantial advances in cancer therapies, developing safe and effective treatment methodologies is critical. Natural (plant-derived compounds), such as flavonoids, might be crucial a methodology without toxicity toward healthy tissues. Prunin flavonoid with potential to used biomedical applications. has yet undergo thorough scientific research, its precise molecular mechanisms of action remain largely unexplored. This review summarizes therapeutic prunin for first time, focusing on underlying an anticancer compound. gained significant attention due antioxidant, anti-inflammatory, effects. aims unlock how functions at level exert effects, primarily modulating key cellular pathways. Furthermore, we have discussed prunin’s adjunctive therapy conventional treatments, highlighting ability strengthen responses while decreasing drug resistance. Moreover, discussion probes into innovative delivery methods, particularly nanoformulations, that address bioavailability, solubility, stability limitations optimize application. By providing comprehensive analysis properties, this stimulate further exploration using agent, thereby progressing development targeted, selective, safe, methods.

Language: Английский

Citations

0
Reactive Oxygen Species in Neurodegenerative Disorders DOI
Arushi Sharma,

Smriti Tiwari,

Himanshu Sharma

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2025, Volume and Issue: unknown, P. 411 - 440

Published: Jan. 3, 2025

Reactive oxygen species (ROS) are chemically reactive molecules containing oxygen. In the context of neurodegenerative disorders, ROS play a dual role while they necessary for normal cellular function, their overproduction can lead to oxidative stress, damaging neurons and contributing pathogenesis diseases such as Alzheimer's, Parkinson's, Huntington's, Amyotrophic Lateral Sclerosis (ALS). This book chapter explores mechanisms by which contributes neurodegeneration, including mitochondrial dysfunction, protein aggregation, inflammation. Additionally, we discuss current emerging therapeutic strategies aimed at modulating levels mitigating damage, antioxidants, gene therapy, lifestyle interventions. Understanding balance between production antioxidant defenses is crucial developing effective treatments diseases.

Language: Английский

Citations

0