Approved antibacterial drugs in the last 10 years: from the bench to the clinic

Published: June 30, 2023

Bacterial infections constitute one of the major cases primary medical incidences worldwide. Historically, fight against bacterial in humans has been an ongoing battle, due to ability bacteria adapt and survive. Indeed, have developed various mechanisms resistance several therapeutic agents. Consequently, scientific community is always interested search new agents, which are able efficiently kill resistant-bacterial strains. This article covers most recent antibacterial molecules approved by Food Drugs Administration (FDA) European Medicines Agency (EMA) from 2012 2022 intends focus on synthetic derivatives give a pedagogical view, with goal highlighting importance organic synthesis obtain greater efficacy. A will be made studies describing structure activity their interactions respective biological targets.

Language: Английский

Palladium‐Catalyzed Carbonylative Cross‐Coupling of Aryl Iodides and Alkenyl Bromides with Benzyl Halides under Reductive Conditions

Asian Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 11(12)

Published: May 13, 2022

Abstract A direct and convenient method for the palladium‐catalyzed reductive cross‐coupling of aryl iodides or alkenyl bromides secondary benzyl halides under ambient CO pressure to generate a diverse array aryl/alkenyl alkyl ketones has been developed. This strategy successfully achieves three‐component carbonylative reaction with Zn as reducing agent C−C bond formation, overcoming well‐known homocoupling halides, between two different electrophiles other coupling reactions. In addition, this avoids use preformed organometallic nucleophiles, such organo‐magnesium, zinc boron reagents. approach enables construction valuable alkyl/alkenyl ketone derivatives (60 examples, 56–95% yields). Reactivity studies indicate that in situ formed benzylic reagents are intermediates catalytic system.

Language: Английский