Understanding Multiple Sclerosis Pathophysiology and Current Disease-Modifying Therapies: A Review of Unaddressed Aspects DOI Creative Commons
Eiman M. A. Mohammed

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(11)

Published: Nov. 19, 2024

Multiple sclerosis (MS) is a complex autoimmune disorder of the central nervous system (CNS) with an unknown etiology and pathophysiology that not completely understood. Although great strides have been made in developing disease-modifying therapies (DMTs) significantly improved quality life for MS patients, these treatments do entirely prevent disease progression or relapse. Identifying unaddressed pathophysiological aspects targeted to fill gaps are essential providing long-term relief patients. Recent research has uncovered some remain outside scope available DMTs, as such, yield only limited benefits. Despite most being by many patients still experience relapse, indicating more detailed understanding necessary. Thus, this literature review seeks explore known pathophysiology, identify present explain why current cannot arrest progression.

Language: Английский

Diversity and function of regulatory T cells in health and autoimmune diseases DOI

Yi Lu,

Xiao‐Yong Man

Journal of Autoimmunity, Journal Year: 2025, Volume and Issue: 151, P. 103357 - 103357

Published: Jan. 12, 2025

Language: Английский

Citations

1
Longitudinal analysis of peripheral immune cells in patients with multiple sclerosis treated with anti‐CD20 therapy DOI Creative Commons
Mie Rye Wæde, Lasse F. Voss,

Christina Kingo

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: 11(10), P. 2657 - 2672

Published: Sept. 15, 2024

Abstract Objective Anti‐CD20 therapy is a highly effective treatment for multiple sclerosis (MS). In this study, we investigated MS‐related changes in peripheral blood mononuclear cell (PBMC) subsets compared to healthy controls and longitudinal related the treatment. Methods Multicolor spectral flow cytometry analysis was performed on 78 samples characterize disease‐ treatment‐related PBMC clusters. Blood from MS patients were collected at baseline up 8 months post‐treatment, with three collection points after initiation. Unsupervised clustering tools manual gating applied identify subclusters of interest quantify changes. Results B cells depleted periphery anti‐CD20 as expected, observed an isolated acute, transitory drop proportion natural killer (NK) NKT among main populations ( P = 0.03, 0.004). Major affected subpopulations cytotoxic immune (NK, NKT, CD8 + T cells), higher reduced brain‐homing ability regulatory function long‐term anti‐CD20‐related effect. Additionally, altered distributions memory exhaustion markers both CD4 cells. Interpretation The findings study elucidate phenotypic clusters NK cells, which have previously been underexplored context therapy. Phenotypic modifications towards more controlled phenotype suggest that these may play critical unrecognized role mediating therapeutic efficacy treatments.

Language: Английский

Citations

0
Understanding Multiple Sclerosis Pathophysiology and Current Disease-Modifying Therapies: A Review of Unaddressed Aspects DOI Creative Commons
Eiman M. A. Mohammed

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(11)

Published: Nov. 19, 2024

Multiple sclerosis (MS) is a complex autoimmune disorder of the central nervous system (CNS) with an unknown etiology and pathophysiology that not completely understood. Although great strides have been made in developing disease-modifying therapies (DMTs) significantly improved quality life for MS patients, these treatments do entirely prevent disease progression or relapse. Identifying unaddressed pathophysiological aspects targeted to fill gaps are essential providing long-term relief patients. Recent research has uncovered some remain outside scope available DMTs, as such, yield only limited benefits. Despite most being by many patients still experience relapse, indicating more detailed understanding necessary. Thus, this literature review seeks explore known pathophysiology, identify present explain why current cannot arrest progression.

Language: Английский

Citations

0