Clinical characteristics of Hispanic patients with anti-SAE dermatomyositis

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Clinical and immunological features of COVID‐19 in patients with anti‐MDA5 dermatomyositis during the omicron wave in Chongqing, China

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(3)

Published: March 1, 2024

Abstract Patients with anti‐melanoma differentiation‐associated gene 5 (anti‐MDA5) dermatomyositis (DM) have a higher risk of coronavirus disease 2019 (COVID‐19) infection. In this longitudinal observational study, we aimed to investigate the clinical and immunological features these patients after COVID‐19 A total 73 anti‐MDA5 DM were recruited from Second Affiliated Hospital Chongqing Medical University during Omicron wave epidemic. Clinical data collected by questionnaire survey electronic medical records. Blood samples used determine immunity responses. From December 9, 2022 March 31, 2023, 67 eligible for final analysis; 68.7% them infected COVID‐19. The most common symptoms observed in upper respiratory symptoms, cases mild or moderate (97.8%). laboratory indexes relativity stable infection (all p > 0.05). Vaccination is not protective factor against (odds ratio: 2.69, 95% confidence interval: 0.81–8.93, = 0.105). Both wildtype (WT) neutralizing antibodies titer BA.5‐specific immunoglobulin G significantly enhanced < 0.01), which was as high healthy controls (HCs). memory B‐cell responses similar between HCs ( However, both WT‐specific CD8 + T cells CD4 reduced conclusion, did deteriorate COVID‐19, turn, increase exacerbation. humoral robust but cellular weakened

Language: Английский

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Prevalence of cutaneous manifestations and myositis-specific antibodies in COVID-19 patients and Anti-PL7 antibodies association with pulmonary radiological severity: A retrospective study

International Journal of Immunopathology and Pharmacology, Journal Year: 2024, Volume and Issue: 38

Published: Jan. 1, 2024

Dermatomyositis (DM) is an idiopathic immune-mediated myopathy, and may involve many organs, including muscles, skin lungs. Myositis-specific autoantibodies (MSAs) are a useful aid in diagnosis DM identifying its clinical subtype. During the COVID-19 pandemic, several studies found similarities regarding lung involvement both DM. Such have prompted speculation of common pathogenetic mechanism. Indeed, viral infections well-known triggers autoimmune diseases. This us to investigate whether circulating MSAs could be markers severity outcome patients. Moreover, we investigated presence cutaneous signs

Language: Английский

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Autoantibodies Targeting G-Protein-Coupled Receptors and RAS-Related Molecules in Post-Acute COVID Vaccination Syndrome: A Retrospective Case Series Study

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2852 - 2852

Published: Dec. 15, 2024

Background/Objectives: While post-acute COVID-19 syndrome is well known and extensively studied, the COVID vaccination (PACVS) a more recent nosological entity that poorly defined at immunopathological level, although it shares many symptoms with sequelae of viral infections. Methods: This single-center retrospective study reports case series 17 subjects vaccinated mRNA or adenoviral vector vaccines who were healthy before had never been infected SARS-CoV-2 but presented similar to PACVS for median time 20 months (min 4, max 32). The medical records all patients referred our outpatient clinic over one-year period retrospectively analyzed. Results: In this group, serological tests showed that, in addition positivity anti-spike protein antibodies, high percentage positive antibodies against G protein-coupled receptors molecules involved response SARS-CoV-2. panel 16 autoantibodies tested, few positively associated some reported by patients: anti-ATR1 lymphadenopathy and/or tonsillitis; anti-ACE2 skin such as ecchymosis, oedema, rash; anti-MAS1 widespread burning sensation; anti-STAB1 oedema rash. Anti-ADRA2A negatively memory loss mental fog. ACE2 correlated serum levels anti-S supporting hypothesis an anti-idiotype mechanism immunopathogenesis PACVS. Conclusions: exploratory analysis suggests directed ACE2, probably also MAS1 STAB1, may serve biomarkers

Language: Английский

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Introduction to the Special Theme Issue: COVID‐19 & Rheumatology: Emerging Insights and Impacts

Arthritis Care & Research, Journal Year: 2023, Volume and Issue: 76(1), P. 1 - 3

Published: Oct. 24, 2023

Language: Английский

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