Volume changes in the contralateral submandibular gland following unilateral gland excision in oral cancer patients DOI Creative Commons
Yei-Jin Kang, Young‐Wook Park, Hang-Moon Choi

et al.

Maxillofacial Plastic and Reconstructive Surgery, Journal Year: 2024, Volume and Issue: 46(1)

Published: Oct. 11, 2024

Abstract Background The effects of unilateral submandibular gland excision on the size contralateral are not well understood, with no human studies reported to date. This study aims investigate impact gland’s size, providing insights into compensatory mechanisms and their clinical implications. Method retrospective involved patients oral cancer who underwent ipsilateral neck dissection at Gangneung-Wonju National University Dental Hospital between 2008 2023. Patients were included if they had preoperative follow-up 3D radiological images. volume was measured using Slicer software preoperative, post-operative, radiographic data. Results mean change 1.35 ± 2.06 cm3, a ratio 1.18 0.24. These changes statistically significant ( p = 0.006). Other factors such as age, gender, radiotherapy did significantly affect > 0.05). Conclusion exhibits increase in following excision, indicating hypertrophy. morphological adaptation should be considered post-operative care surgical planning for optimize outcomes.

Language: Английский

CD4 T cell-secreted IFN-γ in Sjögren's syndrome induces salivary gland epithelial cell ferroptosis DOI Creative Commons

Jiannan Zhou,

Janak L. Pathak,

Tingting Cao

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(4), P. 167121 - 167121

Published: March 11, 2024

Language: Английский

Citations

10
Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS/pSTAT4/AQP5 axis DOI

Jiannan Zhou,

Janak L. Pathak, Lihong Wu

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 218, P. 1 - 15

Published: April 2, 2024

Language: Английский

Citations

6
Updating on the Dual Role of Salivary Gland Epithelial Cell (SGEC) in Sjögren’s Disease DOI Creative Commons

Wen Zhu,

Yun Lu,

Yifan Zhu

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 3039 - 3053

Published: Feb. 28, 2025

Sjögren's disease, an autoimmune inflammatory currently lacks effective treatment options. The salivary gland, a crucial exocrine organ responsible for saliva production and local immune responses on mucous membranes, is frequently impaired in individuals with disease. Restoring gland function poses significant challenge researchers. Salivary epithelial cells, recognized as pivotal components of the have been increasingly implicated key initiators inflammation exhibit innate cell-like properties. On whole, SGEC plays protective role physiological state, can also participate persistence initiating factor pathological state. In review, we explore interplay between Ca+, endoplasmic reticulum (ER), mitochondrial homeostasis imbalance cells. Additionally, provide overview current literature research advancements related to Pattern Recognition Receptors (PRRs), programmed cell death, posttranslational modification (PTM), oral microecology, etc. specifically focusing their implications Given cells onset based may potential alleviate condition by addressing response glands.

Language: Английский

Citations

0
LTK deficiency induces macrophage M2 polarization and ameliorates Sjogren's syndrome by reducing chemokine CXCL13 DOI

Xiuyuan Feng,

Junhui Lu,

Cheng Wei

et al.

Cytokine, Journal Year: 2025, Volume and Issue: 190, P. 156905 - 156905

Published: March 29, 2025

Language: Английский

Citations

0
Functional significance of DNA methylation: epigenetic insights into Sjögren’s syndrome DOI Creative Commons
Yanqing Wang, Farooq Riaz, Wang We

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 6, 2024

Sjögren's syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease with significant global prevalence. It complex condition that requires careful management monitoring. Recent research indicates epigenetic mechanisms contribute to the pathophysiology of SjS by modulating gene expression genome stability. DNA methylation, form modification, fundamental mechanism modifies various genes modifying transcriptional availability regulatory regions within genome. In general, adding methyl group linked inhibition because it changes chromatin structure. methylation fate multiple immune cells, such as leads transition naïve lymphocytes effector lymphocytes. A lack central enzymes frequently results in abnormal activation. Alterations modifications cells or salivary gland epithelial are detected during pathogenesis SjS, representing robust association responses. The analysis beneficial tool for establishing connections between different cell types their SjS. studies related most differentially methylated human leukocyte antigen (HLA) locus. Notably, demethylation sites often observed patients. strongly patients found regulated type I interferon. This process partly B-cell infiltration progression. addition, runt-related transcription factor (RUNX1) gene, lymphotoxin-α (LTA), myxovirus resistance protein (MxA) associated may assist early diagnosis serving potential biomarker. Therefore, this review offers detailed insight into function helps researchers identify biomarkers diagnosis, prognosis, therapeutic targets.

Language: Английский

Citations

2
MiR-34a promotes mitochondrial pathway of apoptosis in human salivary gland epithelial cells by activating NF-κB signaling DOI
Fang He, Juan Yu, Sha Ma

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 758, P. 110063 - 110063

Published: June 14, 2024

Language: Английский

Citations

2
Autoantigen TRIM21 (Ro52) assembles pro-inflammatory immune complexes following lytic cell death DOI

Esther L. Jones,

Benjamin Demarco, Madelon M.E. de Jong

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract Sjögren’s disease (SjD) causes localised and systemic inflammation due to autoantibody production against intracellular proteins, such as TRIM21/Ro52. TRIM21 is an E3 ubiquitin ligase which binds antibody Fc domains on opsonised pathogens, have escaped extracellular immunity entered cytosols; ubiquitinates these, driving their proteasomal degradation. How why becomes autoantigen remains unclear. We show that released upon lytic cell death (pyroptosis/necroptosis) but not apoptosis. Released circulating domains, forms large immune complexes (ICs). These are further enhanced with TRIM21/Ro52 seropositive SjD plasma antibodies, where interactions mediated via both F(ab’) 2 domains. TRIM21-ICs taken up by macrophages, in high interferon environments drive pro-inflammatory responses, antigen presentation, inflammatory metabolic transcriptional changes. Whilst many cytosolic proteins dead cells, its affinity for can generate ICs. This may perpetuate causing be highly autoimmunogenic. One Sentence Summary the protein autoantigen.

Language: Английский

Citations

0
The role of cytokines from salivary gland epithelial cells in the immunopathology of Sjögren’s syndrome DOI Creative Commons
Yuanji Dong, Ting Wang, Huaxiang Wu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 13, 2024

In the pathogenesis and progression of Sjögren's syndrome (SS), hematopoietic cells in peripheral circulation, tissue-resident immune cells, parenchymal salivary gland tissues (such as epithelial endothelial fibroblasts, etc.) all play crucial roles. These diverse form intricate networks interact with each other, leading to tissue destruction persistent chronic inflammation, ultimately causing irreversible damage glandular function. Among these, (SGECs) consistently hold a key position, characterized by their functions expressing co-stimulatory antigen-presenting molecules secreting pro-inflammatory cytokines chemokines. Moreover, SGECs actively engage facilitate development specific pathological structures within gland, such lymphoepithelial lesions (LELs) tertiary lymphoid (TLSs), thereby substantially elevating risk mucosa-associated (MALT) lymphoma. Overall, are recognized for essential irreplaceable contributions SS. This review article initially delves into anatomical composition subsequently focusing on elucidating different derived from SGECs, encompassing chemokines, cytokines, anti-inflammatory pro-survival damage-associated molecular patterns (DAMPs), explore roles

Language: Английский

Citations

0
Volume changes in the contralateral submandibular gland following unilateral gland excision in oral cancer patients DOI Creative Commons
Yei-Jin Kang, Young‐Wook Park, Hang-Moon Choi

et al.

Maxillofacial Plastic and Reconstructive Surgery, Journal Year: 2024, Volume and Issue: 46(1)

Published: Oct. 11, 2024

Abstract Background The effects of unilateral submandibular gland excision on the size contralateral are not well understood, with no human studies reported to date. This study aims investigate impact gland’s size, providing insights into compensatory mechanisms and their clinical implications. Method retrospective involved patients oral cancer who underwent ipsilateral neck dissection at Gangneung-Wonju National University Dental Hospital between 2008 2023. Patients were included if they had preoperative follow-up 3D radiological images. volume was measured using Slicer software preoperative, post-operative, radiographic data. Results mean change 1.35 ± 2.06 cm3, a ratio 1.18 0.24. These changes statistically significant ( p = 0.006). Other factors such as age, gender, radiotherapy did significantly affect > 0.05). Conclusion exhibits increase in following excision, indicating hypertrophy. morphological adaptation should be considered post-operative care surgical planning for optimize outcomes.

Language: Английский

Citations

0