Wireless, Multimodal Monitoring of Organ Health Using 3D-Printed, Barbed, Bioresorbable Stretchable Microneedle Sensor Arrays DOI
Xiang‐Ling Li, Shibo Liu, Jingshan Mo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Comprehensive and continuous assessment of organ physiology biochemistry, beyond the capabilities conventional monitoring tools, can enable timely interventions for intraoperative complications like ischemia nerve injuries postoperative conditions such as dysfunction transplant rejection. Here, we report a wireless implant with 3D-printed, barbed, bioresorbable stretchable microneedle sensor array that offers multimodal metabolism, oxygenation, electrophysiology well spatiotemporal mapping biomarkers across different regions. The development deformation-coupled 3D-printing technique enables 3D-programmable manufacturing microneedles monolithic backward-facing barbs, offering conformal yet robust 3D probing organs dynamic mechanics. Electrochemical functionalization tips serves universal approach localized sensing physiological biochemical parameters, enabling concurrent up to 36 parameters (glucose, uric acid, oxygen, etc. ) 32 sites. An electrically programmable self-destruction mechanism based on crevice corrosion bioresorption eliminates need traumatic retrieval microneedles. Demonstrations in clinically relevant kidney gut disorders animal models highlight broad applications this device intra- monitoring.

Language: Английский

Wireless, Multimodal Monitoring of Organ Health Using 3D-Printed, Barbed, Bioresorbable Stretchable Microneedle Sensor Arrays DOI
Xiang‐Ling Li, Shibo Liu, Jingshan Mo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Comprehensive and continuous assessment of organ physiology biochemistry, beyond the capabilities conventional monitoring tools, can enable timely interventions for intraoperative complications like ischemia nerve injuries postoperative conditions such as dysfunction transplant rejection. Here, we report a wireless implant with 3D-printed, barbed, bioresorbable stretchable microneedle sensor array that offers multimodal metabolism, oxygenation, electrophysiology well spatiotemporal mapping biomarkers across different regions. The development deformation-coupled 3D-printing technique enables 3D-programmable manufacturing microneedles monolithic backward-facing barbs, offering conformal yet robust 3D probing organs dynamic mechanics. Electrochemical functionalization tips serves universal approach localized sensing physiological biochemical parameters, enabling concurrent up to 36 parameters (glucose, uric acid, oxygen, etc. ) 32 sites. An electrically programmable self-destruction mechanism based on crevice corrosion bioresorption eliminates need traumatic retrieval microneedles. Demonstrations in clinically relevant kidney gut disorders animal models highlight broad applications this device intra- monitoring.

Language: Английский

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