Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes DOI Creative Commons

Maurizio Gulino,

Dong‐Hoon Kim, Salvador Pané

et al.

Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: July 5, 2019

The development of implantable neuroelectrodes is advancing rapidly as these tools are becoming increasingly ubiquitous in clinical practice, especially for the treatment traumatic and neurodegenerative disorders. Electrodes have been exploited a wide number neural interface devices, such deep brain stimulation, which one most successful therapies with proven efficacy diseases like Parkinson or epilepsy. However, main caveats related to application electrodes nervous tissue response at injury site, characterized by cascade inflammatory events, culminate chronic inflammation, and, turn, result failure implant over extended periods time. To overcome current limitations widespread macroelectrode based systems, new design strategies innovative materials superior biocompatibility characteristics currently being investigated. This review describes state art vitro, ex vivo models available study microelectrodes. We particularly highlight increased complexity that closely mimic scenarios can serve promising alternatives animal studies investigation microelectrodes tissues. Additionally, we also express our view on impact progress field engineering research.

Language: Английский

Recent Advances and Opportunities of Active Materials for Haptic Technologies in Virtual and Augmented Reality DOI Creative Commons
Tae‐Heon Yang, Jin Ryong Kim, Hanbit Jin

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(39)

Published: March 3, 2021

Abstract Virtual reality and augmented (VR/AR) are evolving. The market demands innovation efforts call for a shift in the key VR/AR technologies engaging people virtually. Tele‐haptics with multimodal bilateral interactions emerging as future of industry. By transmitting receiving haptic sensations wirelessly, tele‐haptics allow human‐to‐human beyond traditional interactions. core include tactile sensing feedback based on highly advanced sensors actuators. Recent developments innovations active materials show that can significantly contribute to addressing needs challenges current technologies. Thus, this paper intends review status opportunities material‐based technology focus applications. It first provides an overview applications actuation. then highlights state‐of‐the‐art interfaces relevant aim provide perspectives role their potential integration devices. This concludes perspective outlook immersive tele‐haptic interaction

Language: Английский

Citations

117
Soft Fiber Electronics Based on Semiconducting Polymer DOI
Fengqiang Sun, Hao Jiang, Haoyu Wang

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(8), P. 4693 - 4763

Published: Feb. 8, 2023

Fibers, originating from nature and mastered by human, have woven their way throughout the entire history of human civilization. Recent developments in semiconducting polymer materials further endowed fibers textiles with various electronic functions, which are attractive applications such as information interfacing, personalized medicine, clean energy. Owing to ability be easily integrated into daily life, soft fiber electronics based on polymers gained popularity recently for wearable implantable applications. Herein, we present a review previous current progress polymer-based electronics, particularly focusing smart-wearable areas. First, provide brief overview viewpoint basic concepts functionality requirements different devices. Then analyze existing associated devices interfaces, healthcare energy conversion storage. The working principle performance summarized. Furthermore, focus fabrication techniques Based continuous one-dimensional yarn, introduce two- three-dimensional fabric fabricating methods. Finally, challenges relevant perspectives potential solutions address related problems.

Language: Английский

Citations

89
Biocompatible Material‐Based Flexible Biosensors: From Materials Design to Wearable/Implantable Devices and Integrated Sensing Systems DOI
Gang Liu, Ziyu Lv, Saima Batool

et al.

Small, Journal Year: 2023, Volume and Issue: 19(27)

Published: April 3, 2023

Abstract Human beings have a greater need to pursue life and manage personal or family health in the context of rapid growth artificial intelligence, big data, Internet Things, 5G/6G technologies. The application micro biosensing devices is crucial connecting technology personalized medicine. Here, progress current status from biocompatible inorganic materials organic composites are reviewed material‐to‐device processing described. Next, operating principles pressure, chemical, optical, temperature sensors dissected these flexible biosensors wearable/implantable discussed. Different systems acting vivo vitro, including signal communication energy supply then illustrated. potential in‐sensor computing for applications sensing also Finally, some essential needs commercial translation highlighted future opportunities considered.

Language: Английский

Citations

87
Insights into Hierarchical Structure–Property–Application Relationships of Advanced Bacterial Cellulose Materials DOI
Zhuotong Wu, Shiyan Chen,

Jing Li

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(12)

Published: Jan. 19, 2023

Abstract Bacterial cellulose (BC) is an environmentally friendly biomaterial that widely investigated because it possesses a unique hierarchical nanofiber network structure as well extraordinary performance. In this review, the formation of BC from perspective biosynthesis illustrated based on its basic chemical and crystal structure. Moreover, design processing BC‐based advanced materials through biosynthesis, physical, and/or modification are also reviewed. The intrinsic characteristics BC, derived structure, analyzed to understand structure–property–application relationships. applications reviewed, such high‐strength structural utilizing properties nanofibers, energy conversion storage, bioelectronic interfaces, environmental remediation, thermal management ion transport 3D structures these materials. addition, authors offer their opinions potential future research directions for sustainably developing

Language: Английский

Citations

71
Robust Neural Interfaces with Photopatternable, Bioadhesive, and Highly Conductive Hydrogels for Stable Chronic Neuromodulation DOI
Ming Yang, Ping Chen, Xinyu Qu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(2), P. 885 - 895

Published: Jan. 11, 2023

A robust neural interface with intimate electrical coupling between electrodes and tissues is critical for stable chronic neuromodulation. The development of bioadhesive hydrogel a potential approach tightly fixing the on epineurium surface to construct interface. Herein, we photopatternable, antifouling, conductive (∼6 S cm–1), (interfacial toughness ∼100 J m–2), soft, elastic (∼290% strain, Young's modulus 7.25 kPa) establish bioelectronics. UV-sensitive zwitterionic monomer can facilitate formation an electrostatic-assembled polymer PEDOT:PSS network, it be further photo-cross-linked into network. Such semi-interpenetrating network endows good conductivity. Especially, photopatternable feature enables facile microfabrication processes multifunctional (MH) characteristic size 50 μm. MH electrodes, which show improved performance impedance, charge storage capacity, injection capability, produce effective stimulation high current density (1 mA cm–2) at ultralow voltages (±25 mV). could realize high-efficient communication recording sciatic nerve in rat model.

Language: Английский

Citations

60
Translational opportunities and challenges of invasive electrodes for neural interfaces DOI
Konlin Shen, Oliver Chen, Jordan Edmunds

et al.

Nature Biomedical Engineering, Journal Year: 2023, Volume and Issue: 7(4), P. 424 - 442

Published: April 20, 2023

Language: Английский

Citations

59
Implantable intracortical microelectrodes: reviewing the present with a focus on the future DOI Creative Commons
Yang Wang,

Xinze Yang,

Xiwen Zhang

et al.

Microsystems & Nanoengineering, Journal Year: 2023, Volume and Issue: 9(1)

Published: Jan. 5, 2023

Abstract Implantable intracortical microelectrodes can record a neuron’s rapidly changing action potentials (spikes). In vivo neural activity recording methods often have either high temporal or spatial resolution, but not both. There is an increasing need to more neurons over longer duration in vivo. However, there remain many challenges overcome before achieving long-term, stable, high-quality recordings and realizing comprehensive, accurate brain analysis. Based on the vision of idealized implantable microelectrode device, performance requirements for are divided into four aspects, including quality, stability, throughput, multifunctionality, which presented order importance. The current possible solutions given from perspective each aspect. developments technology analyzed summarized.

Language: Английский

Citations

58
A strong quick-release biointerface in mussels mediated by serotonergic cilia-based adhesion DOI
Jenaes Sivasundarampillai, Lucia Youssef, Tobias Priemel

et al.

Science, Journal Year: 2023, Volume and Issue: 382(6672), P. 829 - 834

Published: Nov. 16, 2023

The mussel byssus stem provides a strong and compact mechanically mismatched biointerface between living tissue nonliving biopolymer. Yet, in poorly understood process, mussels can simply jettison their entire byssus, rebuilding new one just hours. We characterized the structure composition of using histology, confocal Raman mapping, phase contrast-enhanced microcomputed tomography, advanced electron microscopy, revealing sophisticated junction consisting abiotic biopolymer sheets interdigitated extracellular matrix. sheet surfaces are intimate adhesive contact with billions motile epithelial cilia that control strength release through collective movement, which is regulated neurochemically. posit this may involve complex sensory pathway by sessile respond to environmental stresses relocate.

Language: Английский

Citations

45
Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation DOI Creative Commons
Myeongki Cho,

Jeong-Kyu Han,

Jungmin Suh

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 6, 2024

Abstract Bioresorbable neural implants based on emerging classes of biodegradable materials offer a promising solution to the challenges secondary surgeries for removal implanted devices required existing implants. In this study, we introduce fully bioresorbable flexible hybrid opto-electronic system simultaneous electrophysiological recording and optogenetic stimulation. The soft device, composed materials, has direct optical electrical interface with curved cerebral cortex surface while exhibiting excellent biocompatibility. Optimized minimize light transmission losses photoelectric artifact interference, device was chronically in brain transgenic mice performed photo-stimulate somatosensory area local field potentials. Thus, presented implant system, comprising promises provide monitoring therapy modalities versatile applications biomedicine.

Language: Английский

Citations

28
Bioelectronics for electrical stimulation: materials, devices and biomedical applications DOI
Ya Huang, Kuanming Yao, Qiang Zhang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8632 - 8712

Published: Jan. 1, 2024

Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat broad spectrum health conditions. Electrical stimulation (ES) pivotal technique in bioelectronics, offering precise, non-pharmacological means modulate control processes across molecular, cellular, tissue, organ levels. This method holds potential restore or enhance physiological functions compromised by diseases injuries integrating sophisticated electrical signals, device interfaces, designs tailored specific mechanisms. review explains mechanisms which ES influences cellular behaviors, introduces essential principles, discusses performance requirements for optimal systems, highlights representative applications. From this review, we can realize based bioelectronics therapy, regenerative medicine rehabilitation engineering technologies, ranging from tissue neurological modulation cardiovascular cognitive functions. underscores versatility various biomedical contexts emphasizes need adapt complex clinical landscapes addresses.

Language: Английский

Citations

24