NIR‐II‐Excited Intravital Two‐Photon Microscopy Distinguishes Deep Cerebral and Tumor Vasculatures with an Ultrabright NIR‐I AIE Luminogen

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(44)

Published: Sept. 15, 2019

Abstract Intravital fluorescence imaging of vasculature morphology and dynamics in the brain tumors with large penetration depth high signal‐to‐background ratio (SBR) is highly desirable for study theranostics vascular‐related diseases cancers. Herein, a bright fluorophore (BTPETQ) long‐wavelength absorption aggregation‐induced near‐infrared (NIR) emission (maximum at ≈700 nm) designed intravital two‐photon (2PF) mouse tumor vasculatures under NIR‐II light (1200 excitation. BTPETQ dots fabricated via nanoprecipitation show uniform size around 42 nm quantum yield 19 ± 1% aqueous media. The 2PF labeled by reveals 3D blood vessel network an ultradeep 924 µm. In addition, enhanced due to their unique leaky structures, which facilitates differentiation normal vessels from SBR deep tissues. Moreover, extravasation accumulation (more than 900 µm) visualized This highlights importance developing excitable efficient NIR fluorophores vivo tissue contrast imaging.

Language: Английский

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Tumor-targeting CuS nanoparticles for multimodal imaging and guided photothermal therapy of lymph node metastasis

Acta Biomaterialia, Journal Year: 2018, Volume and Issue: 72, P. 256 - 265

Published: March 26, 2018

Language: Английский

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Dual drug delivery and sequential release by amphiphilic Janus nanoparticles for liver cancer theranostics

Biomaterials, Journal Year: 2018, Volume and Issue: 181, P. 113 - 125

Published: July 30, 2018

Language: Английский

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Effective and Selective Anti‐Cancer Protein Delivery via All‐Functions‐in‐One Nanocarriers Coupled with Visible Light‐Responsive, Reversible Protein Engineering

Advanced Functional Materials, Journal Year: 2018, Volume and Issue: 28(14)

Published: Jan. 31, 2018

Abstract Efficient intracellular delivery of protein drugs and tumor‐specific activation functions are critical toward anti‐cancer therapy. However, an omnipotent system that can harmonize the complicated systemic barriers as well spatiotemporally manipulate function is lacking. Herein, “all‐functions‐in‐one” nanocarrier doped with photosensitizer (PS) developed coupled reactive oxygen species (ROS)‐responsive, reversible engineering to realize cancer‐targeted delivery, spatiotemporal manipulation activities using long‐wavelength visible light (635 nm) at low power density (5 mW cm −2 ). Particularly, RNase A caged H 2 O ‐cleavable phenylboronic acid form 4‐nitrophenyl 4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)benzyl carbonate (NBC)‐modified (RNBC), which encapsulated in acid‐degradable, ketal‐crosslinked PEI (KPEI)‐based nanocomplexes (NCs) coated PS‐modified hyaluronic (HA). Such NCs processes for wherein HA coating renders long blood circulation cancer cell targeting, KPEI enables endosomal escape acid‐triggered RNBC release. Tumor‐specific irradiation generates kill cells restore activity, thus achieving synergistic efficacy. It first time photomanipulate by coupling ROS‐cleavable caging PS‐mediated ROS generation, represents a promising example programmed delivery.

Language: Английский

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A disassembling strategy overcomes the EPR effect and renal clearance dilemma of the multifunctional theranostic nanoparticles for cancer therapy

Biomaterials, Journal Year: 2019, Volume and Issue: 197, P. 284 - 293

Published: Jan. 18, 2019

Language: Английский

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