Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
124(2), P. 554 - 628
Published: Nov. 22, 2023
In
vivo
imaging
technologies
have
emerged
as
a
powerful
tool
for
both
fundamental
research
and
clinical
practice.
particular,
luminescence
in
the
tissue-transparent
near-infrared
(NIR,
700–1700
nm)
region
offers
tremendous
potential
visualizing
biological
architectures
pathophysiological
events
living
subjects
with
deep
tissue
penetration
high
contrast
owing
to
reduced
light–tissue
interactions
of
absorption,
scattering,
autofluorescence.
The
distinctive
quantum
effects
nanocrystals
been
harnessed
achieve
exceptional
photophysical
properties,
establishing
them
promising
category
luminescent
probes.
this
comprehensive
review,
between
light
tissues,
well
advantages
NIR
imaging,
are
initially
elaborated.
Subsequently,
we
focus
on
achieving
improved
by
optimizing
performance
nanocrystal
fluorophores.
ingenious
design
strategies
probes
discussed,
along
their
respective
biomedical
applications
versatile
modalities.
Finally,
thought-provoking
reflections
challenges
prospects
future
translation
nanocrystal-based
wisely
provided.
Small,
Journal Year:
2022,
Volume and Issue:
18(31)
Published: June 28, 2022
Abstract
Fluorescence
imaging
with
high
sensitivity
and
minimal
invasiveness
has
received
tremendous
attention,
which
can
accomplish
visualized
monitoring
evaluation
of
cancer
progression.
Compared
the
conventional
first
near‐infrared
(NIR‐I)
optical
window
(650–950
nm),
fluorescence
in
second
NIR
(NIR‐II,
950–1700
nm)
exhibits
deeper
tissue
penetration
capability
higher
temporal‐spatial
resolution
lower
background
interference
for
achieving
deep‐tissue
vivo
real‐time
development.
Encouraged
by
significant
preponderances,
a
variety
multifunctional
NIR‐II
fluorophores
have
been
designed
fabricated
sensitively
biomarkers
visualizing
treatment
procedure
cancers.
In
this
review,
differences
between
NIR‐I
are
briefly
introduced,
especially
advantages
visualization
tumors
diagnosis.
An
important
focus
is
to
summarize
biomarker
analysis
tumor
visualization,
brief
introduction
imaging‐guided
therapy
also
presented.
Finally,
challenges
reasonable
prospects
diagnosis
clinical
applications
outlined.
Theranostics,
Journal Year:
2022,
Volume and Issue:
12(7), P. 3345 - 3371
Published: Jan. 1, 2022
NIR-II
imaging
is
developed
rapidly
for
noninvasive
deep
tissue
inspection
with
high
spatio-temporal
resolution,
taking
advantage
of
diminished
autofluorescence
and
light
attenuation.Activatable
fluorescence
probes
are
widely
to
report
pathological
changes
accurate
targeting,
among
which
organic
fluorescent
achieve
significant
progress.Furthermore,
the
activatable
exhibited
appealing
characteristics
like
tunable
physicochemical
optical
properties,
easy
processability,
excellent
biocompatibility.In
present
review,
we
highlight
advances
in
design,
synthesis
applications
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
sulfur
(RSS),
pH,
hypoxia,
viscosity
as
well
abnormally
expressed
enzymes.This
non-invasive
modality
shows
a
promising
prospect
targeting
site
envisioned
potential
clinical
translation.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
124(2), P. 554 - 628
Published: Nov. 22, 2023
In
vivo
imaging
technologies
have
emerged
as
a
powerful
tool
for
both
fundamental
research
and
clinical
practice.
particular,
luminescence
in
the
tissue-transparent
near-infrared
(NIR,
700–1700
nm)
region
offers
tremendous
potential
visualizing
biological
architectures
pathophysiological
events
living
subjects
with
deep
tissue
penetration
high
contrast
owing
to
reduced
light–tissue
interactions
of
absorption,
scattering,
autofluorescence.
The
distinctive
quantum
effects
nanocrystals
been
harnessed
achieve
exceptional
photophysical
properties,
establishing
them
promising
category
luminescent
probes.
this
comprehensive
review,
between
light
tissues,
well
advantages
NIR
imaging,
are
initially
elaborated.
Subsequently,
we
focus
on
achieving
improved
by
optimizing
performance
nanocrystal
fluorophores.
ingenious
design
strategies
probes
discussed,
along
their
respective
biomedical
applications
versatile
modalities.
Finally,
thought-provoking
reflections
challenges
prospects
future
translation
nanocrystal-based
wisely
provided.
