A multifunctional chitosan hydrogel dressing for liver hemostasis and infected wound healing

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 291, P. 119631 - 119631

Published: May 19, 2022

Language: Английский

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Hydrogel Bioadhesives with Extreme Acid‐Tolerance for Gastric Perforation Repairing

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(29)

Published: April 9, 2022

Abstract Hydrogel bioadhesives have emerged as one of the most promising alternatives to sutures and staples for wound sealing repairing, owing their unique advantages in biocompatibility, mechanical compliance, minimally invasive manipulation. However, only a few hydrogel been successfully used gastric perforation repair, due undesirable swelling when direct contact with extremely acidic fluids, are thereby accompanied by gradually deteriorating adhesion performance. Herein, an acid‐tolerant (ATGel) bioadhesive is developed, which integrates two distinct components, substrate adhesive polymer brush layer. The ATGel can form instant, atraumatic, fluid‐tight, sutureless perforation, enable robust biointerfaces addressing key limitations commercially‐available tissue adhesives. Moreover, vivo investigation on rat model validates proposed bioadhesion, identifies mechanisms accelerated repair through alleviated inflammation, suppresses fibrosis enhances angiogenesis.

Language: Английский

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Polymerizable rotaxane hydrogels for three-dimensional printing fabrication of wearable sensors

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 10, 2023

While hydrogels enable a variety of applications in wearable sensors and electronic skins, they are susceptible to fatigue fracture during cyclic deformations owing their inefficient resistance. Herein, acrylated β-cyclodextrin with bile acid is self-assembled into polymerizable pseudorotaxane via precise host-guest recognition, which photopolymerized acrylamide obtain conductive rotaxane (PR-Gel). The topological networks PR-Gel all desirable properties this system due the large conformational freedom mobile junctions, including excellent stretchability along superior based strain sensor can sensitively detect distinguish body motions subtle muscle movements. three-dimensional printing fabricated exhibit high resolution altitude complexity, real-time human electrocardiogram signals detected repeating stability. self-heal air, has highly repeatable adhesion skin, demonstrating its great potential sensors.

Language: Английский

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In Situ Forming Dual‐Conductive Hydrogels Enable Conformal, Self‐Adhesive and Antibacterial Epidermal Electrodes

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(38)

Published: May 26, 2023

Abstract Conductive hydrogels (CHs) are regarded as one of the most promising materials for bioelectronic devices on human‐machine interfaces (HMIs). However, conventional CHs cannot conform well with complex skin surfaces, such hairy or wrinkled skin, due to pre‐formation and insufficient adhesion; they also usually lack antibacterial abilities require tissue‐harm time‐consuming preparation (e.g., heating ultraviolet irradiation), which limits their practical application HMIs. Herein, an in situ forming CH is proposed by taking advantage PEDOT:PSS‐promoted self‐polymerization zwitterionic [2‐(methacryloyloxy)ethyl]dimethyl‐(3‐sulfopropyl) (SBMA). The hydrogel formed spontaneously after injection precursor solution onto desired location without any additional treatments. as‐prepared possesses excellent elasticity (elastic recovery >96%), desirable adhesive strength (≈6.5 kPa), biocompatibility, intrinsically properties. Without apparent heat release (<5 °C) during gelation, can form skin. Additionally, obtained establish tight contact highly conformal surfaces irregular wounds. Finally, applied epidermal electrodes record stable reliable surface electromyogram signals from (with high signal‐to‐noise ratio, SNR ≈ 32 dB) accelerate diabetic wound healing under electrical stimulation.

Language: Английский

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Rapid Ultratough Topological Tissue Adhesives

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(35)

Published: July 8, 2022

Tissue adhesives capable of achieving strong and tough adhesion in permeable wet environments are useful many biomedical applications. However, generated through covalent bond formation directly with the functional groups tissues (i.e., COOH NH

Language: Английский

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