Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
28, P. 101217 - 101217
Published: Aug. 24, 2024
Cold
exposure
therapy
(CE),
as
an
inexpensive
method,
has
shown
great
potential
in
cancer
therapy.
Exploring
the
combined
anti-tumor
mechanism
of
CE
and
traditional
therapies
(such
photodynamic
(PDT))
is
exciting
promising.
Here,
a
bionic
aggregation-induced
emission
photosensitizer
system
(named
THL)
designed
for
to
enhance
immunotherapy.
THL
inherits
homologous
targeting
ability
tumor
derived
exosomes,
promoting
enrichment
at
site.
Under
external
illumination,
generates
hydroxyl
radicals
superoxide
anions
through
type
I
PDT.
In
addition,
mice
are
pretreated
with
cold
exposure,
which
promotes
mediated
PDT
reactive
oxygen
species
(ROS)
generation
by
reducing
production
ATP
GSH
tissue.
This
combination
increases
ROS
within
tumor,
inhibits
growth
distant
tumors,
recurrent
rechallenged
tumors
number
cytotoxic
CD8+T
cells
memory
T
cells.
Compared
alone,
shows
greater
advantages
The
strategy
provides
new
ideas
Aggregate,
Journal Year:
2023,
Volume and Issue:
5(2)
Published: Oct. 3, 2023
Abstract
The
induction
of
tumor
carbonyl
stress
is
reported
to
efficiently
revert
immune
suppression
in
the
microenvironment
and
enhance
cancer
immunotherapy.
However,
low
oxygen
concentration
due
inherent
hypoxia
limits
its
catalytic
effect.
Herein,
an
injectable
thermosensitive
hydrogel
system
(named
APH)
developed
for
co‐loading
near‐infrared
(NIR)
aggregation‐induced
emission
(AIE)
nanoparticles
plasma
amine
oxidase
(PAO)
boosting
enhancing
antitumor
immunity.
Upon
808
nm
NIR
laser
irradiation,
AIE
trigger
a
mild‐temperature
(around
45°C)
photothermal
effect
site,
which
significantly
relieves
promotes
released
PAO
inhibit
growth
Myeloid‐derived
suppressor
cells.
Remarkably,
synergistic
therapeutic
APH
verified
through
significant
inhibitory
on
distant
tumor,
enhanced
memory,
effective
postoperative
recurrence,
rechallenge,
metastasis.
Overall,
combined
AIE‐mediated
therapy
by
upon
irradiation
can
activate
immunotherapy,
making
it
promising
treatment
approach
treatment.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(4)
Published: March 5, 2024
Abstract
For
its
vital
role
in
maintaining
cellular
activity
and
survival,
mitochondrion
is
highly
involved
various
diseases,
several
strategies
to
target
mitochondria
have
been
developed
for
specific
imaging
treatment.
Among
these
approaches,
theranostic
may
realize
both
diagnosis
therapy
with
one
integrated
material,
benefiting
the
simplification
of
treatment
process
candidate
drug
evaluation.
A
variety
mitochondria‐targeting
agents
designed
based
on
differential
structure
composition
mitochondria,
which
enable
more
precise
localization
within
at
disease
sites,
facilitating
unveiling
pathological
information
while
concurrently
performing
therapeutic
interventions.
Here,
progress
materials
reported
recent
years
along
background
briefly
summarized,
determining
deliver
updated
status
design
ideas
this
field
readers.
Small,
Journal Year:
2024,
Volume and Issue:
20(29)
Published: Feb. 17, 2024
Abstract
Compared
to
conventional
radiotherapy
(RT),
FLASH‐RT
delivers
ultra‐high
dose
radiation,
significantly
reducing
damage
normal
tissue
while
guaranteeing
the
effect
of
cancer
treatment.
However,
recurrence
and
metastasis
frequently
occur
after
all
RT
due
existence
intractable
stem
cells
(CSCs).
To
address
this,
a
biomimetic
nanoplatform
(named
TAFL)
tumor‐derived
exosome
fusion
liposomes
is
designed
by
co‐loading
aggregation‐induced
emission
photothermal
agents,
TPE‐BBT,
anti‐cancer
drugs,
aspirin,
aiming
clear
CSCs
for
inhibiting
therapy
.
Aspirin
released
in
TAFL
system
triggered
laser
irradiation
can
induce
apoptosis
DNA
4T1
CSCs,
comprehensively
downregulate
their
stemness
phenotype,
inhibit
sphericity.
Furthermore,
TPE‐BBT
mediated
mild‐photothermal
alleviate
hypoxic
tumor
microenvironment,
repair
which
further
amplifies
aspirin
against
therefore
reduces
effective
making
more
biologically
safe.
In
vivo
experimental
results
demonstrated
that
decreased
population
treatment
inhibited
therapy.
summary,
this
provides
new
idea
future
clinical
application
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
37, P. 299 - 312
Published: April 23, 2024
Ultrahigh
dose-rate
(FLASH)
radiotherapy
is
an
emerging
technology
with
excellent
therapeutic
effects
and
low
biological
toxicity.
However,
tumor
recurrence
largely
impede
the
effectiveness
of
FLASH
therapy.
Overcoming
crucial
for
practical
applications.
Here,
we
prepared
agarose-based
thermosensitive
hydrogel
containing
a
mild
photothermal
agent
(TPE-BBT)
glutaminase
inhibitor
(CB-839).
Within
nanoparticles,
TPE-BBT
exhibits
aggregation-induced
emission
peaked
at
900
nm,
while
unrestricted
molecular
motions
endow
photothermy
generation
ability.
The
balanced
effect
photoluminescence
are
ideal
phototheranostics.
Upon
660-nm
laser
irradiation,
temperature-rising
softens
hydrolyzes
to
release
CB-839
into
site
concurrent
therapy
chemotherapy,
jointly
inhibiting
homologous
recombination
repair
DNA.
enhanced
efficiently
kills
tissue
without
obvious
systematic
This
work
deciphers
in
bright
organic
fluorophores
as
source
photothermy,
provides
novel
recurrence-resistant
adverse
side
effects.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
28, P. 101217 - 101217
Published: Aug. 24, 2024
Cold
exposure
therapy
(CE),
as
an
inexpensive
method,
has
shown
great
potential
in
cancer
therapy.
Exploring
the
combined
anti-tumor
mechanism
of
CE
and
traditional
therapies
(such
photodynamic
(PDT))
is
exciting
promising.
Here,
a
bionic
aggregation-induced
emission
photosensitizer
system
(named
THL)
designed
for
to
enhance
immunotherapy.
THL
inherits
homologous
targeting
ability
tumor
derived
exosomes,
promoting
enrichment
at
site.
Under
external
illumination,
generates
hydroxyl
radicals
superoxide
anions
through
type
I
PDT.
In
addition,
mice
are
pretreated
with
cold
exposure,
which
promotes
mediated
PDT
reactive
oxygen
species
(ROS)
generation
by
reducing
production
ATP
GSH
tissue.
This
combination
increases
ROS
within
tumor,
inhibits
growth
distant
tumors,
recurrent
rechallenged
tumors
number
cytotoxic
CD8+T
cells
memory
T
cells.
Compared
alone,
shows
greater
advantages
The
strategy
provides
new
ideas
