Unidirectional gene delivery electrospun fibrous membrane via charge repulsion for tendon repair DOI Creative Commons
Jingwen Liu, Liang Chen, Zhenyu Sun

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 37, P. 191 - 205

Published: March 21, 2024

Gene therapy is capable of efficiently regulating the expression abnormal genes in diseased tissues and expected to be a therapeutic option for refractory diseases. However, unidirectional targeting gene always desired at tissue interface. In this study, inspired by principle that like charges repulse each other, positively charged micro-nano electrospun fibrous membrane with dual-layer structure was developed electrospinning technology achieve delivery siRNA-loaded cationic nanocarriers, thus realizing tendon-paratenon Under charge repulsion layer, more COX-2 siRNA nanocarriers were enriched peritendinous tissue, which not only improved bioavailability drug prevent adhesion formation, but also avoided adverse effects on fragile endogenous healing tendon itself. summary, study provides an innovative strategy interface diseases utilizing facilitate drugs.

Language: Английский

Prevention and treatment of inflammatory arthritis with traditional Chinese medicine: Underlying mechanisms based on cell and molecular targets DOI
Wenhao Li, Lei Yu, Wenming Li

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 89, P. 101981 - 101981

Published: June 10, 2023

Language: Английский

Citations

47
Multi‐Bioinspired MOF Delivery Systems from Microfluidics for Tumor Multimodal Therapy DOI Creative Commons
Qingfei Zhang, Gaizhen Kuang, Hanbing Wang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(33)

Published: Oct. 18, 2023

Metal-organic framework (MOF)-based drug delivery systems have demonstrated values in oncotherapy. Current research endeavors are centralized on the functionality enrichment of featured MOF materials with designed versatility for synergistic multimodal treatments. Here, inspired by multifarious biological functions including ferroptosis pattern, porphyrins, and cancer cell membrane (CCM) camouflage technique, novel multi-biomimetic nanocarriers from microfluidics prepared. The Fe

Language: Английский

Citations

47
A Fused Membrane‐Camouflaged Biomimetic Nanosystem for Dual‐Targeted Therapy of Septic Arthritis DOI Open Access

Zeping Yu,

Mengxian Wang, Junqiao Li

et al.

Small, Journal Year: 2025, Volume and Issue: 21(9)

Published: Jan. 19, 2025

Abstract Due to the inherent aseptic and enclosed characteristics of joint cavity, septic arthritis (SA) almost inevitably leads intractable infections rapidly progressing complex pathological environments. Presently, SA faces not only deficient effectiveness gold‐standard systemic antibiotic therapy but also scarcity effective localized targeted approaches standardized animal models. Herein, an ingenious multifunctional nanosystem is designed, which involves methylation hyaluronic acid (HA), copolymerization with DEGDA, loading vancomycin (VAN), then coating fused macrophage‐platelet membrane (denoted as FM@HA@VAN). Upon intra‐articular administration, FM@HA@VAN nanoparticles exhibit sustained retention selectively targeting infected sites, leveraging macrophage‐mediated inflammation homing platelet‐directed bacteria targeting. The acidic microenvironment triggers responsive release vancomycin, leading potent bactericidal effects. Subsequently, exposed HA@VAN are efficiently internalized by activated macrophages, releasing HA alleviate oxidative stress achieve chondroprotection inhibiting pro‐inflammatory cytokines, neutralizing ROS upregulating macrophage M2 polarization. In vivo model experiments confirm efficacy this dual‐targeting antibacterial approach, demonstrating its precision in eradicating bacterial alleviating associated processes, including synovial hyperplasia cartilage erosion. therapeutic nanosystem, coordinated fused‐membranes, holds promise for enhancing treatment SA.

Language: Английский

Citations

2
Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines DOI Creative Commons
Chong Qiu,

Jun Zhe Zhang,

Bo Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 29, 2023

Abstract Traditional Chinese Medicines (TCMs) have been used for centuries the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due poor water solubility, low bioavailability, potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles organic/inorganic nanohybrids based on active constituents from TCMs extensively studied promising strategy improve achieve higher therapeutic effect with fewer side effects compared conventional formulations. This review summarizes recent advances in nanocarrier-based systems types TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, quinones, different natural sources. covers design preparation nanocarriers, characterization, vitro/vivo evaluations. Additionally, this highlights challenges opportunities field suggests future directions research. Nanocarrier-based shown great improving efficacy serve comprehensive resource researchers field. Graphical abstract

Language: Английский

Citations

28
Hyaluronic acid-based multifunctional carriers for applications in regenerative medicine: A review DOI
Chuanfeng An, Hanting Li, Yanqiu Zhao

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 231, P. 123307 - 123307

Published: Jan. 15, 2023

Language: Английский

Citations

27
Oral Administration of Multistage Albumin Nanomedicine Depots (MANDs) for Targeted Efficient Alleviation of Chronic Inflammatory Diseases DOI

Fangke Zhang,

Yawei Du, Jiancheng Zheng

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(9)

Published: Jan. 13, 2023

Abstract Methotrexate (MTX) by oral taking has been employed as the first‐line medication for various chronic inflammatory diseases treatment, such Crohn's disease and rheumatoid arthritis (RA). However, administration of MTX very limited clinical benefits will be discontinued due to suboptimal response severe adverse effects on intestinal mucosa. Herein, a multistage albumin nanomedicine depot (denoted MAND) is formulated encapsulating MTX‐loaded human serum nanoparticles (MTX@HSA NPs) into calcium alginate chitosan microcapsules using gas‐shearing technology. The MANDs can provide protection MTX@HSA NPs with well‐persisted biologic activity against gastric acid erosion realize specific boost release in tract mild basic circumstance. absorbed intestine selectively accumulate inflammation lesion exploiting targeting ability HSA. In animal experiments, show improved therapeutic efficacy treatment both RA colitis minimized side respect free administration. Therefore, this conceived promote more clinic popularity enhanced diseases.

Language: Английский

Citations

24
Development of biomedical hydrogels for rheumatoid arthritis treatment DOI Creative Commons
Mirza Muhammad Faran Ashraf Baig,

Lee Ki Wong,

Abdul Wasy Zia

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(1), P. 100887 - 100887

Published: Feb. 1, 2024

Rheumatoid Arthritis (RA) is an autoimmune disorder that hinders the normal functioning of bones and joints reduces quality human life. Every year millions people are diagnosed with RA worldwide which particularly includes elderly women groups. Therefore, this global cause warrants development new biomaterials, medicines, therapeutic methods for treatment. This will improve Healthcare Access Quality Index also relieve administrative financial burdens healthcare service providers at a scale. Hydrogels soft cross-linked polymeric materials can store certain number fluids, drugs biomolecules hydration applications. biocompatible exhibit excellent mechanical properties like providing elastic cushions to articulating by mimicking natural synovial fluid. Hence, hydrogels create biological environment within cavity decrease reactions friction. lubricate joint surfaces prevent degradation cartilage, thus conceiting high potential treat RA. work reviews progress in injectable implantable hydrogels, synthesis methods, types drugs, advantages challenges, discusses role targeted drug delivery, mechanistic behaviour, tribological performance

Language: Английский

Citations

17
Balancing macrophage polarization via stem cell-derived apoptotic bodies for diabetic wound healing DOI Creative Commons
Jiayi Mao, Shutong Qian,

Qiuyu Zhao

et al.

Med, Journal Year: 2024, Volume and Issue: 5(2), P. 148 - 168.e8

Published: Feb. 1, 2024

BackgroundAdipose tissue-derived stem cell-derived apoptotic bodies (ADSC-ABs) have shown great potential for immunomodulation and regeneration, particularly in diabetic wound therapy. However, their local application has been limited by unclear regulatory mechanisms, rapid clearance, short tissue retention times.MethodsWe analyzed the key role molecules pathways of ADSC-ABs regulating inflammatory macrophages mRNA sequencing microRNA (miRNA) then verified them gene knockdown. To prevent we employed microfluidics technology to prepare methacrylate-anhydride gelatin (GelMA) microspheres (GMS) controlled release ABs. Finally, evaluated effectiveness ADSC-AB-laden GMSs (ABs@GMSs) a rat model.FindingsOur results demonstrated that effectively balanced macrophage polarization through janus kinase (JAK)-signal transducer activator transcription (STAT) pathway, mediated miR-20a-5p. Furthermore, showed AB@GMSs had good biocompatibility, significantly delayed clearance ABs, ameliorated inflammation promoted vascularization, thus facilitating its healing.ConclusionsOur study reveals mechanism balancing highlightsthe importance delaying GMSs. These findings important implications development novel therapies healing.FundingThis research was supported National Key Research Development Program China (2020YFA0908200), Natural Science Foundation (82272263, 82002053, 32000937, 82202467), Shanghai "Rising Stars Medical Talents" Youth (22MC1940300), Municipal Health Commission (20204Y0354), Technology Funds (22YF1421400).

Language: Английский

Citations

17
Endoperoxide‐enhanced self‐assembled ROS producer as intracellular prodrugs for tumor chemotherapy and chemodynamic therapy DOI Creative Commons
Junjie Tang, Yadong Liu, Yifan Xue

et al.

Exploration, Journal Year: 2024, Volume and Issue: 4(4)

Published: Feb. 9, 2024

Abstract Prodrug‐based self‐assembled nanoparticles (PSNs) with tailored responses to tumor microenvironments show a significant promise for chemodynamic therapy (CDT) by generating highly toxic reactive oxygen species (ROS). However, the insufficient level of intracellular ROS and limited drug accumulation remain major challenges further clinical transformation. In this study, PSNs delivery artesunate (ARS) are demonstrated designing pH‐responsive ARS‐4‐hydroxybenzoyl hydrazide (HBZ)‐5‐amino levulinic acid (ALA) (AHA NPs) self‐supplied excellent chemotherapy CDT. The greatly improved loading capacity generation from endoperoxide bridge using electron withdrawing group attached directly C10 site artesunate. ALA ARS‐HBZ could be released AHA NPs under cleavage hydrazone bonds triggered acidic surroundings. Besides, increased heme in mitochondria, promoting lipid peroxidation anti‐tumor effects. Our study ARS through chemical modification, pointing out potential applications fields.

Language: Английский

Citations

14
Nanomedicines targeting activated immune cells and effector cells for rheumatoid arthritis treatment DOI

Yasi Deng,

Hao Zheng, Bin Li

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 498 - 515

Published: June 12, 2024

Language: Английский

Citations

12