Journal of Polymer Science,
Journal Year:
2024,
Volume and Issue:
62(22), P. 4966 - 4992
Published: Aug. 9, 2024
Abstract
In
recent
years,
the
prevalence
of
bone
diseases
is
showing
an
increasing
trend,
which
mainly
attributed
to
aging
global
population.
However,
repair
and
regeneration
are
still
unsolved
problem
in
treatment
diseases,
include
a
series
biological
events.
Photocrosslinked
natural
hydrogel‐based
microspheres
(PNHMs)
spherical
particles
composed
photocrosslinked
hydrogel
components.
Due
their
morphology,
injectability,
biocompatibility,
PNHMs
widely
used
tissue
regeneration,
particularly
for
defects.
this
article,
we
review
available
materials
PNHMs,
then
introduce
preparation
methods.
After
that,
summarize
important
advanced
functionalities
PNHMs.
For
example,
can
be
loaded
with
different
active
ingredients
exert
anti‐inflammatory,
antibacterial,
antioxidant
effects,
while
also
realizing
lubrication
due
specific
shape
size
distribution.
addition,
function
capturing
ions
realized
via
coordination.
When
applied
engineering,
promote
angiogenesis
osteogenesis,
great
potential
diseases.
Finally,
challenges
prospects
discussed.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(19)
Published: March 29, 2024
Abstract
The
management
of
critical‐sized
bone
defects
presents
a
formidable
clinical
challenge,
especially
given
the
increasing
incidence
diseases
in
aging
population.
Consequently,
there
is
an
increased
demand
for
minimally
invasive
repair
materials
that
can
effectively
address
this
particularly
outpatient
settings.
In
study,
goal
to
develop
injectable
and
biodegradable
biomaterial
adheres
fills
bone‐defect
sites
support
regeneration.
osteogenic
angiogenic
activities
animal
horn
peptides
are
investigated
by
incorporating
them
into
biologically
active
moieties,
combination
with
novel
thermosensitive
hydrogel.
resulting
hydrogel
exhibited
essential
biological
functionalities,
allowing
precise
modulation
its
physical
chemical
properties.
Notably,
peptide
rapidly
filled
defect
site,
promoting
both
angiogenesis
induction.
approach
significantly
accelerates
new
summary,
findings
study
present
promising,
solution
addressing
defects.
Biomimetics,
Journal Year:
2024,
Volume and Issue:
9(7), P. 418 - 418
Published: July 8, 2024
Biomimetic
gels
are
synthetic
materials
designed
to
mimic
the
properties
and
functions
of
natural
biological
systems,
such
as
tissues
cellular
environments.
This
manuscript
explores
advancements
future
directions
injectable
biomimetic
in
biomedical
applications
highlights
significant
potential
hydrogels
wound
healing,
tissue
regeneration,
controlled
drug
delivery
due
their
enhanced
biocompatibility,
multifunctionality,
mechanical
properties.
Despite
these
advancements,
challenges
resilience,
degradation
rates,
scalable
manufacturing
remain.
discusses
ongoing
research
optimize
properties,
develop
cost-effective
production
techniques,
integrate
emerging
technologies
like
3D
bioprinting
nanotechnology.
Addressing
through
collaborative
efforts
is
essential
for
unlocking
full
engineering
regenerative
medicine.
Journal of Polymer Science,
Journal Year:
2024,
Volume and Issue:
62(22), P. 4966 - 4992
Published: Aug. 9, 2024
Abstract
In
recent
years,
the
prevalence
of
bone
diseases
is
showing
an
increasing
trend,
which
mainly
attributed
to
aging
global
population.
However,
repair
and
regeneration
are
still
unsolved
problem
in
treatment
diseases,
include
a
series
biological
events.
Photocrosslinked
natural
hydrogel‐based
microspheres
(PNHMs)
spherical
particles
composed
photocrosslinked
hydrogel
components.
Due
their
morphology,
injectability,
biocompatibility,
PNHMs
widely
used
tissue
regeneration,
particularly
for
defects.
this
article,
we
review
available
materials
PNHMs,
then
introduce
preparation
methods.
After
that,
summarize
important
advanced
functionalities
PNHMs.
For
example,
can
be
loaded
with
different
active
ingredients
exert
anti‐inflammatory,
antibacterial,
antioxidant
effects,
while
also
realizing
lubrication
due
specific
shape
size
distribution.
addition,
function
capturing
ions
realized
via
coordination.
When
applied
engineering,
promote
angiogenesis
osteogenesis,
great
potential
diseases.
Finally,
challenges
prospects
discussed.
