Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(42)
Published: Aug. 31, 2023
Diradicals
based
on
the
Blatter
units
and
connected
by
acetylene
alkene
spacers
have
been
prepared.
All
molecules
show
sizably
large
diradical
character
low
energy
singlet-triplet
gaps.
Their
photo-physical
properties
concerning
their
lowest
excited
state
studied
in
detail
steady-state
time-resolved
absorption
spectroscopy.
We
fully
identified
main
optical
band
full
absence
of
emission
from
state.
A
computational
study
has
also
carried
out
that
helped
to
identify
presence
a
conical
intersection
between
ground
which
produces
highly
efficient
light-to-heat
conversion
absorbed
radiation.
Furthermore,
an
outstanding
photo-thermal
77.23
%
confirmed,
close
highest
diradicaloid
field.
For
first
time,
stable
diradicals
are
applied
therapy
tumor
cells
with
good
stability
satisfactory
performance
at
near-infrared
region.
Chemical Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
discusses
design
strategies
for
external
stimuli-driven
hydrogels
with
in
situ
catalytic
processes.
It
highlights
precise
control
over
the
properties,
elucidating
regulatory
mechanisms
and
deepening
understanding
of
applications.
Wound
bacterial
infections
pose
a
significant
challenge
to
global
public
health.
Nitric
oxide
(NO),
an
endogenous
gaseous
molecule,
shows
great
potential
in
antibacterial
therapy.
However,
efficient
NO
delivery
remains
critical
challenge.
Photothermal
therapy
(PTT)
offers
noninvasive
and
highly
localized
treatment
for
infections.
Leveraging
the
advantages
of
both
approaches,
this
study
developed
polymer-based
nanocarrier
achieve
synergistic
PTT.
For
first
time,
amphiphilic
polyurethane
PEG-PNU-PEG
containing
dinitrate
donors
were
synthesized,
which
further
self-assembled
into
polymeric
nanomicelles
loaded
with
NIR
emitting
conjugated
polymer.
In
microenvironment,
elevated
glutathione
(GSH)
triggered
release.
Simultaneously,
polymer
enabled
effective
photothermal
therapy,
promoting
release
gas
Experimental
results
demonstrated
that
PTT
effectively
eradicated
bacteria,
eliminating
69.93%
±
2.79%
S.
aureus
biofilm,
>
4.5-fold
improvement
compared
alone
(14.8%
2.92%).
The
vitro
assay
showed
inhibition
rate
exceeding
99.0%,
while
vivo
studies
on
infected
skin
wounds
revealed
clearance
95.0%
1.95%.
Furthermore,
system
suppressed
inflammatory
cytokines,
promoted
collagen
deposition,
accelerated
regeneration,
providing
strategy
broad-spectrum
wound
healing.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(42)
Published: Aug. 31, 2023
Diradicals
based
on
the
Blatter
units
and
connected
by
acetylene
alkene
spacers
have
been
prepared.
All
molecules
show
sizably
large
diradical
character
low
energy
singlet-triplet
gaps.
Their
photo-physical
properties
concerning
their
lowest
excited
state
studied
in
detail
steady-state
time-resolved
absorption
spectroscopy.
We
fully
identified
main
optical
band
full
absence
of
emission
from
state.
A
computational
study
has
also
carried
out
that
helped
to
identify
presence
a
conical
intersection
between
ground
which
produces
highly
efficient
light-to-heat
conversion
absorbed
radiation.
Furthermore,
an
outstanding
photo-thermal
77.23
%
confirmed,
close
highest
diradicaloid
field.
For
first
time,
stable
diradicals
are
applied
therapy
tumor
cells
with
good
stability
satisfactory
performance
at
near-infrared
region.
