X‐Ray‐triggered Carbon Monoxide and Manganese Dioxide Generation based on Scintillating Nanoparticles for Cascade Cancer Radiosensitization

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(23)

Published: March 17, 2023

Abstract Carbon monoxide (CO) is an endogenous signaling molecule with broad therapeutic effects. Here, a multifunctional X‐ray‐triggered carbon and manganese dioxide (MnO 2 ) generation nanoplatform based on metal carbonyl scintillating nanoparticles (SCNPs) reported. Attributed to the radioluminescent characteristic of SCNPs, UV‐responsive Mn 10 not only indirectly activated release CO by X‐ray but can also be degraded into MnO . A high dose used as glycolytic inhibitor for tumor suppression; it will sensitize cells radiotherapy. Meanwhile , photolytic byproduct has both glutathione (GSH) depletion Fenton‐like 2+ delivery properties produce highly toxic hydroxyl radical (⋅OH) in tumors. Thus, this strategy realize X‐ray‐activated release, GSH depletion, ⋅OH cascade cancer radiosensitization. Furthermore, vivo demonstrates MRI contrast effect, making potential theranostic nanoplatform.

Language: Английский

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Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.

Language: Английский

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Combination of biodegradable hydrogel and antioxidant bioadhesive for treatment of breast cancer recurrence and radiation skin injury

Bioactive Materials, Journal Year: 2023, Volume and Issue: 31, P. 408 - 421

Published: Sept. 2, 2023

Postoperative radiotherapy is the standard method for inhibition of breast cancer recurrence and metastasis, whereas radiation resistant ineluctable skin injury are still key problems encountered in prognosis cancer. Herein, we design an internally implantable biodegradable hydrogel extracutaneously applicable antioxidant bioadhesive to concurrently prevent postoperative tumor radioactive after adjuvant radiotherapy. The silk fibroin/perfluorocarbon loading doxorubicin (DOX) formed by consecutive ultrasonication-induced β-sheets-crosslinked amphiphilic fibroin/perfluorocarbon/DOX nanoemulsion, exhibits continuous release oxygen physiological environment improve hypoxia sensitivity radiotherapy, as well simultaneous DOX finally achieve effective anti-cancer effect. A stretchable fabricated copolymerization α-thioctic acid N, N-diacryloyl-l-lysine, gold nanorods gallic loaded into afford gentle photothermal therapy functions. near-infrared light-induced controlled mild can efficiently eliminate excess free radicals generated promote wound healing. Ultimately, vivo animal studies substantiate efficacy our methodology, wherein post-tumor resection administration concomitant application patch effectively inhibit attenuate progression damage.

Language: Английский

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Therapeutic application of manganese-based nanosystems in cancer radiotherapy

Biomaterials, Journal Year: 2023, Volume and Issue: 302, P. 122321 - 122321

Published: Sept. 11, 2023

Language: Английский

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Selenium Nanoparticles Enhance NK Cell‐Mediated Tumoricidal Activity in Malignant Pleural Effusion via the TrxR1‐IL‐18RAP‐pSTAT3 Pathway

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(30)

Published: March 14, 2024

Abstract Malignant pleural effusion (MPE) poses a significant challenge in local treatment, primarily attributed to its intricate tumor immune microenvironment. The immunosuppression of natural killer (NK) cells within the microenvironment, exacerbated by selenium (Se) deficiency, constitutes pivotal treatment bottleneck. Building upon prior investigations, this study delves into impact and mechanisms functionalized lentinan nanoparticles (LET‐SeNPs) on NK MPE, presenting novel strategy for lung adenocarcinoma with malignant (MPE‐LA). synergistic application LET‐SeNPs serves replenish Se levels modulate cells, augment their quantity, restore enhance functionality. Additionally, facilitate activation through TrxR1‐IL18RAP‐pSTAT3 pathway, resulting effective cancer cell eradication reduced production. Furthermore, pre‐stimulation LET‐SeNPs, combined CAR‐NK therapy, harnesses innate system, exhibiting potent anti‐tumor effect. This research introduces compelling advance clinical implementation targeted nanomaterials or lead compounds explicit targets mechanisms, thereby enhancing therapy comprehensive diagnosis MPE.

Language: Английский

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Selenium‐Doped Nanoheterojunctions for Highly Efficient Cancer Radiosensitization

Advanced Science, Journal Year: 2024, Volume and Issue: 11(29)

Published: June 3, 2024

Abstract Exploring efficient and low‐toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression poor prognosis remains one critical developmental challenges in radiotherapy. Nanoheterojunctions, due their unique physicochemical properties, have demonstrated excellent radiosensitization effects energy deposition lifting tumor radiotherapy inhibition. Herein, they doped selenium (Se) into prussian blue (PB) construct a nano‐heterojunction (Se@PB), which could promote increase Fe 2+ /Fe 3+ ratio conversion Se high valence state with introduction. The ‐Se‐Fe electron transfer chain accelerates rate on surface nanoparticles, turn endows it X‐ray transport capability, enhances physical sensitivity. Furthermore, Se@PB induces glutathione (GSH) depletion accumulation pro‐Fenton reaction, thereby disturbs redox balance cells biochemical sensitivity As an radiosensitizer, effectively induced mitochondrial dysfunction DNA damage, promotes cell apoptosis synergistic cervical cancer This study elucidates mechanism Se‐doped nanoheterojunction from perspective biochemistry provides low‐toxic strategy

Language: Английский

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Multi‐Metallic Nanosheets Reshaping Immunosuppressive Tumor Microenvironment through Augmenting cGAS‐STING Innate Activation and Adaptive Immune Responses for Cancer Immunotherapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 9, 2024

The highly immunosuppressive tumor microenvironment (TME) restricts the efficient activation of immune responses. To restore surveillance system for robust activation, vast efforts are devoted to normalizing TME. Here, a manganese-doped layered double hydroxide (Mn-LDH) is developed potent anti-tumor immunity by reversing Mn-LDH synthesized via one-step hydrothermal method. In addition inherent proton neutralization capacity LDH, introduction manganese oxide endows LDH with an additional ability produce oxygen. effectively releases Mn

Language: Английский

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Anaerobic Probiotics-in situ Se nanoradiosensitizers Selectively Anchor to Tumor with Immuno-regulations for Robust Cancer Radio-immunotherapy

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123117 - 123117

Published: Jan. 21, 2025

Language: Английский

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High‐Valence Selenium Nanotherapeutics Downregulates MUC16 to Drive Precise Ovarian Cancer Therapy through Redox Perturbation

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract Abnormal expression of transmembrane mucin 16 (MUC16) in ovarian cancer (OC) can promote progression epithelial–mesenchymal transformation, enhance tumor cell proliferation, migration, and invasion. Therefore, herein a targeted therapeutic high‐valence selenium (Se) nanomedicine (MUC16‐SeMnf@Res) is designed, which target MUC16 to recognize OC simultaneously inhibit achieve efficient treatment OC. The valence bidirectional editing strategy used design synthesize Se nanosystem (SeMnf) through triggering redox reaction between triclinic manganese dioxide nanoflower (Mnf), inducing the conversion 4+ Mn 2+ . increased ratio within SeMnf disrupt intracellular homeostasis by glutathione (GSH) depletion reactive oxygen species (ROS) overproduction. Moreover, effects ROS overproduction are further amplified loaded resveratrol (Res), significantly induces mitochondrial dysfunction inhibited expression, then promoting caspase‐activated apoptosis as well migration inhibitory. Taken together, this study not only sheds light on important role designing OC‐targeting drugs, but also provides simple translational developing nanotherapeutics with strong redox‐homeostasis disrupting capability realize MUC16‐targeting therapy.

Language: Английский

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Radiotherapy-activated tumor immune microenvironment: Realizing radiotherapy-immunity combination therapy strategies

Nano Today, Journal Year: 2023, Volume and Issue: 53, P. 102042 - 102042

Published: Oct. 31, 2023

Language: Английский

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