ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
6(4), P. 1112 - 1119
Published: Feb. 26, 2024
Metal
ion-carbon
based
nanomaterials
served
as
nanozymes
to
mimic
the
biocatalytic
performance
of
natural
enzymes.
However,
there
are
still
challenges
in
constructing
carbon
dots
(CDs)–metal
with
same
coordination
structure
on
chemistry
and
revealing
effect
metal
ion
species
enzyme-mimicking
catalyzed
activities.
Herein,
EDTA-functionalized
dots–metal
(CDsEDTA-Me)
different
ions
(Fe3+,
Cu2+,
Co2+)
structures
synthesized
chemistry.
Species
CDsEDTA-Me
determines
CDsEDTA-Fe,
CDsEDTA-Cu,
CDsEDTA-Co
display
significant
peroxidase
(POD)-mimicking,
superoxide
dismutase
(SOD)-mimicking
activities,
hydroxyl
radical
(•OH)
scavenging
ability,
respectively.
Compared
horseradish
peroxidase,
affinity
CDsEDTA-Fe
H2O2
is
improved
by
47
times.
The
Vm
value
TMB
substrate
1.19
×
10–7
M
s–1.
POD-mimicking
activity
increases
linearly
increase
stability
constants
CDsEDTA-Me,
which
indicates
that
can
be
predicted
CDsEDTA-Me.
provides
a
strategy
for
construction
CDs-metal
rational
improvement
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(49)
Published: Aug. 1, 2023
Abstract
Bacterial
infection
and
impaired
angiogenesis
make
the
treatment
of
diabetic
foot
ulcers
(DFU)
extremely
challenging.
Cationic
polymers
are
expected
to
treat
infected
wounds
due
their
excellent
antibacterial
properties,
but
still,
it
is
difficult
meet
therapeutic
needs
pro‐angiogenesis
anti‐infections
simple
construction
units
outmoded
synthesis
methods.
Herein,
a
cationic
poly(pentahydropyrimidine)
(PPHP)
library
with
strong
modifiability
synthesized
construct
hybrid
hydrogel
synergistic
effects
for
DFUs.
It
found
that
as‐synthesized
can
up‐regulate
angiogenesis‐related
gene
(HIF‐1,
VEGF,
bFGFR/bFGF)
expression
targeted
disruption
bacterial
cell
membranes,
which
finally
promotes
healing
DFU
(wound
rate:
92%)
within
10
days.
This
hydrogel,
thus,
holds
great
promise
in
developing
new
strategies
significantly
enhance
other
bacterial‐infected
pathological
diagnoses.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(11)
Published: Dec. 27, 2023
Abstract
Treatment
of
diabetic
wounds
is
a
significant
clinical
challenge
due
to
the
massive
infections
caused
by
bacteria.
In
this
study,
multifunctional
glycol
chitosan
and
polydopamine‐coated
BiO
1‐x
I
(GPBO)
nanoparticles
(NPs)
with
near‐infrared
(NIR)
photothermal
photocatalytic
abilities
are
prepared.
When
infection
occurs,
local
microenvironment
becomes
acidic,
pH‐switchable
GPBO
can
target
bacteria
wound
site.
The
NIR‐assisted
treatment
exhibits
anti‐bacterial
effects
fast
response,
high
efficiency,
long
duration
Escherichia
coli,
Pseudomonas
aeruginosa
,
Staphylococcus
aureus
.
achieves
excellent
imaging
CT
mouse
subcutaneous
abscess
model.
With
assistance
NIR
irradiation,
promotes
healing
model
anti‐bacteria,
anti‐inflammation,
M2
polarization
promotion
macrophages,
angiogenesis.
This
first‐time
report
nano‐sized
I.
synthesis
selected
application
for
targeted
therapy
presented.
study
offers
an
example
NP‐assisted
precise
diagnosis
bacterial
diseases.
ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
6(4), P. 1112 - 1119
Published: Feb. 26, 2024
Metal
ion-carbon
based
nanomaterials
served
as
nanozymes
to
mimic
the
biocatalytic
performance
of
natural
enzymes.
However,
there
are
still
challenges
in
constructing
carbon
dots
(CDs)–metal
with
same
coordination
structure
on
chemistry
and
revealing
effect
metal
ion
species
enzyme-mimicking
catalyzed
activities.
Herein,
EDTA-functionalized
dots–metal
(CDsEDTA-Me)
different
ions
(Fe3+,
Cu2+,
Co2+)
structures
synthesized
chemistry.
Species
CDsEDTA-Me
determines
CDsEDTA-Fe,
CDsEDTA-Cu,
CDsEDTA-Co
display
significant
peroxidase
(POD)-mimicking,
superoxide
dismutase
(SOD)-mimicking
activities,
hydroxyl
radical
(•OH)
scavenging
ability,
respectively.
Compared
horseradish
peroxidase,
affinity
CDsEDTA-Fe
H2O2
is
improved
by
47
times.
The
Vm
value
TMB
substrate
1.19
×
10–7
M
s–1.
POD-mimicking
activity
increases
linearly
increase
stability
constants
CDsEDTA-Me,
which
indicates
that
can
be
predicted
CDsEDTA-Me.
provides
a
strategy
for
construction
CDs-metal
rational
improvement
