Ce6-modified Fe ions-doped carbon dots as multifunctional nanoplatform for ferroptosis and photodynamic synergistic therapy of melanoma DOI Creative Commons
Haiqiu Li,

Yichen Dou,

Hang Yang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 10, 2024

Abstract Background Despite the higher sensitivity of melanoma towards ferroptosis and photodynamic therapy (PDT), lack efficient inducers poor solubility photosensitizers restrict their synergistic strategies. With unique advantages, carbon dots (CDs) are expected to serve as innovative building blocks for combination cancers. Results Herein, an ferroptosis/PDT integrated nanoplatform is constructed based on chlorin e6-modified Fe ions-doped (Fe-CDs@Ce6). As a novel type iron-carbon hybrid nanoparticles, as-prepared Fe-CDs can selectively activate ferroptosis, prevent angiogenesis inhibit migration mouse skin cells (B16), but have no toxicity normal cells. The nano-conjugated structures facilitate not only aqueous dispersibility Ce6, also self-accumulation ability Fe-CDs@Ce6 within area without requiring extra targets. Moreover, therapeutic effects synergistically enhanced due increased GSH depletion by PDT elevated singlet oxygen ( 1 O 2 ) production efficiency Fe-CDs. When combined with laser irradiation, tumor growth be significantly suppressed through cyclic administration. T -weighted magnetic resonance imaging (MRI) capability reveals potentials cancer diagnosis navigation therapy. Conclusions Our findings indicate multifunctionality in effectively combining therapy, targeting MRI imaging, which enables become promising biocompatible treatment melanoma. Graphic

Language: Английский

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging DOI
Zheng Yang, Tiantian Xu, Hui Li

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 11047 - 11136

Published: Sept. 7, 2023

Advances in nanotechnology and nanomaterials have attracted considerable interest play key roles scientific innovations diverse fields. In particular, increased attention has been focused on carbon-based exhibiting extended structures unique properties. Among these materials, zero-dimensional structures, including fullerenes, carbon nano-onions, nanodiamonds, dots, possess excellent bioaffinities superior fluorescence properties that make suitable for application to environmental biological sensing, imaging, therapeutics. This review provides a systematic overview of the classification structural properties, design principles preparation methods, optical sensing applications nanomaterials. Recent interesting breakthroughs sensitive selective imaging heavy metal pollutants, hazardous substances, bioactive molecules as well information encryption, super-resolution photoacoustic phototherapy nanomedicine delivery are main focus this review. Finally, future challenges prospects materials highlighted envisaged. presents comprehensive basis directions designing, developing, applying fascinating fluorescent sensors fabricated based specific requirements numerous research

Language: Английский

Citations

123
Doping Engineering to Modulate Lattice and Electronic Structure for Enhanced Piezocatalytic Therapy and Ferroptosis DOI Open Access
Boshi Tian, Ruixue Tian, Shaohua Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: July 12, 2023

Piezocatalytic therapy, which generates reactive oxygen species (ROS) under mechanical force, has garnered extensive attention for its use in cancer therapy owing to deep tissue penetration depth and less O2 -dependence. However, the piezocatalytic therapeutic efficiency is limited poor piezoresponse, low separation of electron-hole pairs, complicated tumor microenvironment (TME). Herein, a biodegradable, porous Mn-doped ZnO (Mn-ZnO) nanocluster with enhanced piezoelectric effect constructed via doping engineering. Mn-doping not only induces lattice distortion increase polarization but also creates rich vacancies (OV ) suppressing recombination leading high-efficiency generation ROS ultrasound irradiation. Moreover, shows TME-responsive multienzyme-mimicking activity glutathione (GSH) depletion ability mixed valence Mn (II/III), further aggravating oxidative stress. Density functional theory calculations show that can improve performance enzyme Mn-ZnO due presence OV . Benefiting from boosting GSH ability, significantly accelerate accumulation lipid peroxide inactivate peroxidase 4 (GPX4) induce ferroptosis. The work may provide new guidance exploring novel sonosensitizers therapy.

Language: Английский

Citations

85
Recent advances in photo‐responsive carbon dots for tumor therapy DOI Creative Commons
Huiqi Zhang, Yupeng Liu, Songnan Qu

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2)

Published: May 1, 2024

Abstract The precision treatment of tumors with minimal side effects is associated improved human health and quality life. In recent years, phototherapy has attracted significant attention in tumor therapy due to its versatility, spatiotemporal controllability, non‐resistance, effects. Carbon dots (CDs) are considered promising reagents because their simple preparation, facilitated surface modification, tunable energy bands, excellent electron‐transfer capabilities, remarkable photoelectric photothermal conversion properties, outstanding biocompatibility. This review summarizes advancements photo‐responsive CDs for photodynamic the emerging photocatalytic tumors. Finally, article discusses main challenges development oncology therapeutics strategies overcome these challenges.

Language: Английский

Citations

45
Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application DOI
Liang Chen, Shanshan Zhang,

Yanqiu Duan

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(3), P. 1167 - 1315

Published: Jan. 1, 2024

Silicon-based biomaterials have been extensively developed in the past decades. The classification, characteristics, multi-dimensional design, and biomedical applications of silicon-containing are comprehensively elaborated.

Language: Английский

Citations

31
Biophilic Positive Carbon Dot Exerts Antifungal Activity and Augments Corneal Permeation for Fungal Keratitis DOI
Huiying Chen, Xiwen Geng,

Qingyun Ning

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(13), P. 4044 - 4053

Published: March 22, 2024

Fungal keratitis (FK) is an infectious eye disease that poses a significant risk of blindness. However, the effectiveness conventional antifungal drugs limited due to intrinsic ocular barrier impedes drug absorption. There urgent need develop new therapeutic strategies effectively combat FK. Herein, we synthesized ultrasmall positively charged carbon dot using simple stage-melting method. The can penetrate corneal by opening tight junctions, allowing them reach lesion site and kill fungi. results both in vitro vivo demonstrated it exhibited good biocompatibility activity, significantly improving effect mouse model Therefore, this biophilic size positive dot, characterized its ability properties, may offer valuable insights into design effective nanomedicines.

Language: Английский

Citations

17
A Multifunctional Covalent Organic Framework Nanozyme for Promoting Ferroptotic Radiotherapy against Esophageal Cancer DOI
Lele Zhou, Qun Guan, Wei Zhou

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(20), P. 20445 - 20461

Published: Oct. 6, 2023

Radiotherapy is inevitably accompanied by some degree of radiation resistance, which leads to local recurrence and even therapeutic failure. To overcome this limitation, herein, we report the room-temperature synthesis an iodine- ferrocene-loaded covalent organic framework (COF) nanozyme, termed TADI-COF-Fc, for enhancement radiotherapeutic efficacy in treatment radioresistant esophageal cancer. The iodine atoms on COF not only exerted a direct effect radiotherapy, increasing its X-ray absorption, but also promoted radiolysis water, increased production reactive oxygen species (ROS). In addition, ferrocene surface decoration disrupted redox homeostasis levels hydroxyl lipid peroxide radicals depleting intracellular antioxidants. Both vitro vivo experiments substantiated excellent response TADI-COF-Fc. This study demonstrates potential COF-based multinanozymes as radiosensitizers suggests possible integration strategy combination oncotherapy.

Language: Английский

Citations

35
Advantages of Nanomedicine in Cancer Therapy: A Review DOI
Chao Wang, Shan Zhang

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(24), P. 22594 - 22610

Published: Dec. 4, 2023

Nanomedicines, emerging as an innovative category of cancer therapeutics, have garnered increasing attention from both researchers and the broader public. However, despite this surge in interest, a focused comprehensive discussion highlighting their distinct advantages over small molecule drugs remains conspicuously absent. This knowledge gap not only piques curiosity general audience but also leaves engaged these investigations with partial insights, rather than understanding. deficiency represents critical juncture that demands earnest consideration. In light context, present study endeavors to consolidate elucidate unique merits nanomedicines, particularly contrast traditional drugs, within realm treatment. We meticulously summarized 14 nanomedicine, alongside recent advanced applications, special focus on past three years. Our objective is 2-fold: first, provide clear understanding facilitates precise design second, offer nonspecialists accessible platform for grasping concepts establishing strong foundation widespread awareness. essence, our aims bridge knowledge, shedding unparalleled potential nanomedicines therapy, we believe findings hold great promise advancing scientific research public field.

Language: Английский

Citations

30
Recent advances in carbon dots-based nanoplatforms: Physicochemical properties and biomedical applications DOI

Shiqiao Rui,

Luming Song,

Jiaru Lan

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 476, P. 146593 - 146593

Published: Oct. 10, 2023

Language: Английский

Citations

29
Efficient Protection of Paper‐Based Cultural Relics via In Situ Synthesis of Carbon Dots/Layered Double Hydroxide DOI

Jinchan Zhao,

Mingliang Zhang, Sinong Wang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: April 1, 2024

Abstract Paper‐based cultural relics are of great value and have been facing irreversible damage caused by multiple factors, among which acid hydrolysis ultraviolet photodegradation the main processes leading to paper deterioration. Paper protection highly relies on a limited range materials with single functions, design new that ensure long‐term safety efficiency simultaneously addressing issues acidification UV degradation in is desired. In this study, introduction carbon dots (CDs)‐enhanced layered double hydroxides (LDH) 0D/2D nanohybrids (CDs/Mg‐Al LDH)  is proposed as novel dual‐functional for against acidification. Through CDs‐assisted situ growth strategy, CDs/Mg‐Al LDH ultrathin thickness (≈9.1 nm) CDs‐intercalated structure achieved. The demonstrate high dispersibility, strong absorption, remarkable photostability, resulting protected‐paper decelerated acidification, oxidation, yellowing under both accelerated UV‐aging dry‐heat conditions. Additionally, can emit uniform blue light 365 nm excitation allows easy identification distributed within paper, marking unique practical feature. This research paces direction paper‐based emerging dots‐based nanomaterials.

Language: Английский

Citations

10
“Two-Stage Rocket-Propelled” Strategy Boosting Theranostic Efficacy with Mitochondria-Specific Type I–II Photosensitizers DOI

Xihao Yang,

Xiaoxuan Zhang,

Zhaoyi Yang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(8), P. 9816 - 9825

Published: Feb. 21, 2024

Imaging-guided photodynamic therapy (PDT) holds great potential for tumor therapy. However, achieving the synergistic enhancement of reactive oxygen species (ROS) generation efficiency and fluorescence emission photosensitizers (PSs) remains a challenge, resulting in suboptimal image guidance theranostic efficacy. The hypoxic microenvironment also hinders efficacy PDT. Herein, we propose "two-stage rocket-propelled" photosensitive system cell ablation. This utilizes MitoS, mitochondria-targeted PS, to ablate cells. Importantly, MitoS can react with HClO generate more efficient MitoSO, significantly improved quantum yield. Both MitoSO exhibit less O

Language: Английский

Citations

9