Hydrogels with Differentiated Hydrogen‐Bonding Networks for Bioinspired Stress Response

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(21)

Published: March 28, 2024

Abstract Stress response, an intricate and autonomously coordinated reaction in living organisms, holds a reversible, multi‐path, multi‐state nature. However, existing stimuli‐responsive materials often exhibit single‐step monotonous reactions due to the limited integration of structural components. Inspired by cooperative interplay extensor flexor cells within Mimosa's pulvini, we present hydrogel with differentiated hydrogen‐bonding (H‐bonding) networks designed enable biological stress response. Weak H‐bonding domains resemble cells, confined hydrophobic network stabilized strong clusters (acting like cells). Under external force, are disrupted, facilitating water diffusion from bottom layer enabling transient expansion pressure gradient along thickness direction. Subsequently, diffuses upward, gradually equalizing pressure, while weak undergo elastic deformation. Consequently, undergoes sequence reversible pluralistic motion responses, similar touch‐triggered Intriguingly, it exhibits stress‐dependent color shifts under polarized light, highlighting its potential for applications time‐sensitive “double‐lock” information encryption systems. This work achieves response inspired natural tissues using simple hydrogel, paving way substantial advancements development intelligent soft robots.

Language: Английский

---

Closed-loop recycling of tough epoxy supramolecular thermosets constructed with hyperbranched topological structure

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 7, 2024

The regulation of topological structure covalent adaptable networks (CANs) remains a challenge for epoxy CANs. Here, we report strategy to develop strong and tough supramolecular thermosets with rapid reprocessability room-temperature closed-loop recyclability. These were constructed from vanillin-based hyperbranched resin (VanEHBP) through the introduction intermolecular hydrogen bonds dual dynamic bonds, as well formation intramolecular cavities. structures confer remarkable energy dissipation capability thermosets, leading high toughness strength. Due imine exchange reversible noncovalent crosslinks, can be rapidly effectively reprocessed at 120 °C within 30 s. Importantly, efficiently depolymerized room temperature, recovered materials retain structural integrity mechanical properties original samples. This may employed design tough, recyclable practical applications.

Language: Английский

---

Oral administration microrobots for drug delivery

Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 163 - 190

Published: May 21, 2024

Oral administration is the most simple, noninvasive, convenient treatment. With increasing demands on targeted drug delivery, traditional oral treatment now facing some challenges: 1) biologics how to implement and ensure bioavailability not lower than subcutaneous injections; 2) How achieve therapy of drugs in gastrointestinal tract? Based these two issues, delivery microrobots have shown great application prospect due their characteristics flexible locomotion or driven ability. Therefore, this paper summarizes various developed recent years divides them into four categories according different driving modes: magnetic-controlled microrobots, anchored self-propelled biohybrid microrobots. As involve disciplines such as materials science, mechanical engineering, medicine, control systems, begins by introducing barriers that must overcome. Subsequently, it provides an overview typical involved design process To enhance readers' understanding working principles we present a guideline for designing Furthermore, current development status types reviewed, summarizing respective advantages limitations. Finally, considering significant concerns regarding safety clinical translation, discuss challenges prospections translation presented paper, providing corresponding suggestions addressing existing challenges.

Language: Английский

---

Advances in Soft Strain and Pressure Sensors

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Soft strain and pressure sensors represent a breakthrough in material engineering nanotechnology, providing accurate reliable signal detection for applications health monitoring, sports management, human-machine interface, or soft robotics, when compared to traditional rigid sensors. However, their performance is often compromised by environmental interference off-axis mechanical deformations, which lead nonspecific responses, as well unstable inaccurate measurements. These challenges can be effectively addressed enhancing the sensors' specificity, making them responsive only desired stimulus while remaining insensitive unwanted stimuli. This review systematically examines various materials design strategies developing with high specificity target physical signals, such tactility, distribution, body motions, artery pulse. highlights approaches that impart special properties suppress from factors temperature, humidity, liquid contact. Additionally, it details structural designs improve sensor under different types of deformations. concludes discussing ongoing opportunities inspiring future development highly specific electromechanical

Language: Английский

---

Magnetic Micro/nanorobots in Cancer Theranostics: From Designed Fabrication to Diverse Applications

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Cancer poses a substantial threat and serious challenge to public human health, driving the promotion of sophisticated technologies for cancer therapy. While conventional chemotherapy has bottlenecks such as low delivery efficiency, strong toxic side effects, tumor enrichment barriers, magnetic micro/nanorobots (MNRs) emerge promising therapeutic candidates that provide alternative strategies MNR is kind human-made machine micro- or nanosized, reasonably designed, performs command tasks through self-actuated externally controlled propulsion mechanisms, which can be potentially applied in theranostics. Here, this review first introduces components constitute typical MNR, including body part, control function sensing part. Subsequently, elucidates representative fabrication methods construct MNRs from top-down approaches bottom-up approaches, covering injection molding, self-rolling, melt electrospinning writing, deposition, biotemplate method, lithography, assembling, 3D printing, chemical synthesis. Furthermore, focuses on multiple applications facing diagnosis treatment, encompassing imaging, quantification, drug release, synergy with therapies, cell manipulation, surgical assistance. Then, systematically elaborates biocompatibility biosafety MNRs. Finally, challenges faced by are discussed alongside future research directions. This intended scientific guidance may improve comprehension cognition theranostics platform MNRs, promoting prospering practical application development

Language: Английский

---

A Novel Strategy for Designing High-Performance Self-Healing Polysiloxane-Polyurea Composites Enhanced by Dopamine-Grafted Cellulose Nanofibers and Zn2+

Composites Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 111159 - 111159

Published: March 1, 2025

Language: Английский

---

Water‐Driven Malleable, Weldable and Eco‐Friendly Recyclable Carbon Fiber Reinforced Dynamic Composites^†

Chinese Journal of Chemistry, Journal Year: 2023, Volume and Issue: 42(5), P. 516 - 522

Published: Nov. 13, 2023

Comprehensive Summary Traditional carbon fiber‐reinforced polymers based on thermoset matrix have been extensively used in the fields of wind turbine blades, automotive sector, and aerospace, among many others. However, there is still a major challenge recycling those due to high cost adverse impacts environment. In this work, we apply polyimine network as matrix, which possess considerable tensile thermal properties, prepare fiber reinforced materials with trifluoromethyl diphenoxybenzene units (CFRFP) using prepreg‐based compression molding method. The CFRFP can be reshaped or reprocessed by heat water rapidly, exhibited multifunction, including welding, chemical recycling, etc . These unique findings gained from our study will facilitate manufacturing capability enrich types composites.

Language: Английский

---

Magnetic Soft Matter toward Programmable and Multifunctional Miniature Machines

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(2), P. 173 - 183

Published: Jan. 22, 2024

ConspectusMiniature machines that are highly controllable have received widespread attention due to their potential applications in smart medicine and micromanipulation, especially those developed based on soft matter. The inherent compliance of matter can enhance the adaptability miniature a complex working environment or objects being manipulated. Furthermore, with rapid development materials science control technology, emergence various responsive matters has promoted remote even autonomous actuation capabilities as well reconfigurable properties. Despite burgeoning efforts devoted programming precise machines, exploration is still its infancy. Due nonlinearity response active matter, comprehensive understanding modeling deformation needed. Besides, systematic study on-demand material components physical properties at submillimeter, micro-, nanoscale levels also important. Hence, more in-depth research composition, mechanisms, methods needed promote construction novel practical future.Based regulation fields chemical substances, demonstrate shape-morphing without restraint. Among stimulation methods, magnetic strategy possesses outstanding advantages terms safety, controllability, penetration depth, which endow huge fundamental engineering applications. Programmable provides powerful platform explore patterns locomotion behaviors nature. Under action nonuniform torques generated by programmable stimulation, could undergo series morphological transformations. promising solution for developing optimized speed energy density. Therefore, through exquisite assembly structural design, composed compatible many application scenarios, biomedical engineering.In this Account, we provide overview recent significant advancements achieved our group others First, elucidate interaction mechanism between diverse agents available matrices including polymer matrices, liquid non-Newtonian fluids. We then illustrate encoding heterogeneous magnetization profile particle orientation, 3D transformations under (e.g., origami kirigami deformation, surface Gaussian curvature). Next, discussed, focusing devices, flexible electronics. Finally, an outlook prospects opportunities future

Language: Английский

---

Hard magnetics and soft materials—a synergy

Smart Materials and Structures, Journal Year: 2024, Volume and Issue: 33(4), P. 043001 - 043001

Published: Feb. 21, 2024

Abstract Hard-magnetic soft materials (hMSMs) are smart composites that consist of a mechanically polymer matrix impregnated with hard magnetic filler particles. This dual-phase composition renders them exceptional magneto-mechanical properties allow to undergo large reversible deformations under the influence external fields. Over last decade, hMSMs have found extensive applications in robotics, adaptive structures, and biomedical devices. However, despite their widespread utility, they pose considerable challenges fabrication characterization owing multi-phase nature, miniature length scales, nonlinear material behavior. Although noteworthy attempts been made understand coupled rudimentary concepts inter-phase interactions give rise mechanical nonlinearity remain insufficiently understood, this impedes further advancements. holistic review addresses these standalone bridges gaps by providing thorough examination myriad techniques, applications, experimental, modeling approaches. Specifically, presents wide spectrum ranging from traditional molding cutting-edge four-dimensional printing, unbounded prospects diverse fields research. The covers various approaches, including continuum frameworks encompassing phenomenological homogenization models, as well microstructural models. Additionally, it emerging techniques like machine learning-based context hMSMs. Finally, expansive landscape promising systems is provided for better understanding prospective

Language: Английский

---

Sustainable, recyclable and biodegradable castor oil-derived elastomers enabled by dynamic acetoacetyl formed amides

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 491, P. 152195 - 152195

Published: May 12, 2024

Language: Английский

---