Regulating Mitochondrial Aging via Targeting the Gut‐Bone Axis in BMSCs With Oral Hydrogel Microspheres to Inhibit Bone Loss DOI

Qu Xiao,

Xie Zhou,

Jun Zhang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract The gut‐bone axis is a promising target for osteoporosis treatment, yet existing delivery systems lack precise targeting. Herein, an oral hydrogel microsphere system (E7‐Lipo@Alg/Cs) developed using gas microfluidic and ionic crosslinking technologies to deliver drugs bone marrow mesenchymal stem cells (BMSCs) via the axis, regulating mitochondrial aging. A BMSC‐affine peptide conjugated onto liposomes encapsulating Fisetin, followed by incorporation into alginate‐calcium microspheres. Chitosan electrostatically adsorbed surface, creating core‐shell structure that adheres intestinal epithelial cells, withstands gastric acid, facilitates targeted BMSCs through intestinal‐bone axis. In vitro, effectively enhances function reverses BMSC aging, while in vivo studies demonstrate prolonged drug activity, restored osteogenic differentiation, regeneration. RNA‐seq indicates activation of AMPK‐SIRT1 pathway, reversing aging promoting aged tissue This provides efficient strategy preventing loss, offering significant clinical potential treatment.

Language: Английский

Electrospun fiber‐based immune engineering in regenerative medicine DOI Creative Commons

Yiru Xu,

Qimanguli Saiding, Xue Zhou

et al.

Smart Medicine, Journal Year: 2024, Volume and Issue: 3(1)

Published: Feb. 1, 2024

Abstract Immune engineering, a burgeoning field within regenerative medicine, involves spectrum of strategies to optimize the intricate interplay between tissue biomaterials and host tissue. These are applied across different types various disease models, which encompasses finely modulating immune response at levels cells factors, aiming mitigate adverse effects like fibrosis persistent inflammation that may arise injury site consequently promote regeneration. With continuous progress in electrospinning technology, immunoregulatory capabilities electrospun fibers have gained substantial attention over years. Electrospun fibers, with their extracellular matrix‐like characteristics, high surface‐area‐to‐volume ratio, reliable pharmaceutical compound capacity, emerged as key players among engineering materials. This review specifically focuses on role fiber‐based emphasizing unique design strategies. Notably, actively engages by responses through four essential strategies: (i) surface modification, (ii) drug loading, (iii) physicochemical parameters, (iv) biological grafting. presents comprehensive overview mechanisms system injured tissues while unveiling adopted orchestrate regulation. Furthermore, explores current developmental trends limitations concerning function drive advancements its full potential.

Language: Английский

Citations

62
Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy DOI

Yinuo Yang,

Hongyu Zhang

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(30)

Published: May 1, 2024

Abstract Osteoarthritis (OA), a prevalent joint disease affecting many people globally, presents significant challenge in current treatments, which often only manage symptoms without halting progression. This review illuminates novel approaches OA therapy, focusing mainly on intra‐articular injection of nanomaterials. The innovative materials, designed to either mimic or augment natural lubrication, show promise restoring biomechanics and alleviating pain. delves into an array biomimetic lubricants, including polymer brush, nanocomposite hydrogel, nanoparticles, underscoring their roles anti‐inflammation, targeting, cartilage repair, drug delivery. Furthermore, the potential mesenchymal stem cells differentiate chondrocytes, coupled with delivery these exosomes via nanomaterials, has promoted cell therapy avenues for OA. also highlights function non‐coding RNAs such as miRNA, siRNA, circRNA, lncRNA, antisense oligonucleotides impeding progression, nanomaterials facilitating delivery, thus advanced therapeutic possibilities immune evasion bone proliferation. Overall, this encapsulates evolution treatment from material cell, ultimately gene forecasting future where evolve toward integrated, personalized diagnostics therapeutics

Language: Английский

Citations

12
Recent developments of polymeric delivery systems in gene therapeutics DOI
Yijia Li,

Ruizhen Tian,

Jiayun Xu

et al.

Polymer Chemistry, Journal Year: 2024, Volume and Issue: 15(19), P. 1908 - 1931

Published: Jan. 1, 2024

A brief overview of main strategies to improve the gene transfection efficiency PCVs recently and their applications in certain diseases.

Language: Английский

Citations

8
Cuttlefish‐Inspired Photo‐Responsive Antibacterial Microparticles with Natural Melanin Nanoparticles Spray DOI
Chuanhui Song,

Xiangyi Wu,

Yu Wang

et al.

Small, Journal Year: 2023, Volume and Issue: 20(19)

Published: Dec. 5, 2023

Abstract Topical antibiotics can be utilized to treat periodontitis, while their delivery stratagems with controlled release and long‐lasting bactericidal inhibition are yet challenging. Herein, inspired by the defensive behavior of cuttlefish expelling ink, this work develops innovative thermal‐responsive melanin‐integrated porous microparticles (MPs) through microfluidic synthesis for periodontitis treatment. These MPs composed melanin nanoparticles (NPs), poly(N‐isopropylacrylamide) (PNIPAM), agarose. Benefiting from excellent biocompatibility large surface area ratio MPs, they deliver abundant NPs. Under near‐infrared irradiation, NPs convert photo energy into thermal energy. This leads agarose melting subsequent shrinkage microspheres induced pNIPAM, thereby facilitating In addition, released serve as a highly effective photothermal agent, displaying potent antibacterial activity against porphyromonas gingivalis possessing natural anti‐inflammatory properties. unique characteristics further demonstrated in vivo experiments, showing effects treatment infected wounds periodontitis. Therefore, catfish‐inspired photo‐responsive controlled‐release drug hold tremendous potential clinical applications.

Language: Английский

Citations

16
Research Progress on Injectable Microspheres as New Strategies for the Treatment of Osteoarthritis Through Promotion of Cartilage Repair DOI
Jianjing Lin, Shicheng Jia, Fuyang Cao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: March 4, 2024

Abstract Osteoarthritis (OA) is a degenerative disease caused by variety of factors with joint pain as the main symptom, including fibrosis, chapping, ulcers, and loss cartilage. Traditional treatment can only delay progression OA, classical delivery system have many side effects. In recent years, microspheres shown great application prospects in field OA treatment. Microspheres support cells, reproduce natural tissue microenvironment vitro vivo, are an efficient for release drugs or biological agents, which promote cell proliferation, migration, differentiation. Thus, they been widely used cartilage repair regeneration. this review, preparation processes, basic materials, functional characteristics various commonly systematically reviewed. Then it introduced surface modification strategies that improve properties discussed series applications microsphere functionalized scaffolds Finally, based on bibliometrics research, research development, future potential, possible hotspots therapy dynamically evaluated. The comprehensive systematic review will bring new understanding to OA.

Language: Английский

Citations

7
Intra-articular sustained-release of pirfenidone as a disease-modifying treatment for early osteoarthritis DOI Creative Commons
Xiaobo Zhu, Mingde Cao, Kejia Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 255 - 272

Published: May 23, 2024

Osteoarthritis (OA) is a major clinical challenge, and effective disease-modifying drugs for OA are still lacking due to the complicated pathology scattered treatment targets. Effective early treatments urgently needed prevent progression. The excessive amount of transforming growth factor β (TGFβ) one causes synovial fibrosis subchondral bone sclerosis, such pathogenic changes in precede cartilage damage. Herein we report novel strategy intra-articular sustained-release pirfenidone (PFD), clinically-approved TGFβ inhibitor, achieve effects on joints. We found that PFD effectively restored mineralization presence TGFβ1 (as those levels patients' fluid). A monthly injection was then designed using poly lactic-

Language: Английский

Citations

5
Mitochondrial biogenesis microcarriers break membrane barriers for endogenous nucleus pulposus repair DOI
Xiaohu Li, Hongze Chang, Libin Pang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160668 - 160668

Published: Feb. 1, 2025

Citations

0
Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy DOI Creative Commons
Zhuoming Xu, Jintao Liu,

Hanyin Hu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 17, 2025

Osteoarthritis is one of the most common degenerative joint diseases, which seriously affects life middle-aged and elderly people. Traditional treatments such as surgical treatment systemic medication, often do not achieve expected or optimal results, leads to severe trauma a variety side effects. Therefore, there an urgent need develop novel therapeutic options overcome these problems. Hydrogels are widely used in biomedical tissue repairing platform for loading drugs, proteins stem cells. In recent years, smart-responsive hydrogels have achieved excellent results drug delivery systems osteoarthritis. This review focuses on advances endogenous stimuli (including enzymes, pH, reactive oxygen species temperature, etc.) responsive exogenous light, shear, ultrasound magnetism, osteoarthritis treatment. Finally, current limitations application future prospects smart summarized.

Language: Английский

Citations

0
Polypropylene mesh coated with hyaluronic acid/polyvinyl alcohol composite hydrogel for preventing bowel adhesion DOI
Dandan Wei, Yulin Huang, Min Liang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132061 - 132061

Published: May 3, 2024

Language: Английский

Citations

4
Injectable Regenerated Silk Fibroin Micro/Nanosphere with Enhanced Permeability and Stability for Osteoarthritis Therapy DOI
Zixiang Wang,

Xueyang Yin,

Chenyang Zhuang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(46)

Published: Aug. 5, 2024

Abstract In the therapy of early‐stage osteoarthritis, to accomplish full infiltration subchondral bone and cartilage, target osteoclast chondrocyte simultaneously remain challenges in biomaterials design. Herein, a novel hierarchical drug delivery system is introduced, with micrometer‐scale outer layer spheres composed regenerated silk fibroin, characterized by connected porous structure through n‐butanol fibroin combined emulsion route freezing method. The design effectively resists clearance from joint cavity, ensuring stable prolonged residence time within space. Additionally, incorporates phenylboronic acid‐enriched nanoparticles, stabilized chemical cross‐linking, which encapsulate isoliquiritin derived Glycyrrhiza uralensis. These nanoparticles facilitate complete penetration cartilage extracellular matrix, exhibit pH‐responsive behavior, neutralize reactive oxygen species, enable controlled release, thereby enhancing therapeutic efficacy. vitro vivo experiments both demonstrate that composite micro/nanospheres not only inhibit osteoclastogenesis loss osteophyte formation, but also mitigate chondrocytes apoptosis, reduce oxidative stress associated degeneration, ameliorate neuropathic hyperalgesia, underlying mechanisms being elucidated. study indicates such an injectable strategy combining organic Chinese medicine holds substantial promise for treatment early osteoarthritis.

Language: Английский

Citations

4