Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Gas
therapy
using
gasotransmitters
is
of
exponential
interest
due
to
the
growing
recognition
gas
signaling
molecules
that
can
be
involved
in
multiple
therapeutic
actions.
Finding
suitable
methods
for
delivering
these
crucial,
and
porous
materials,
notably
metal-organic
frameworks
(MOFs),
have
shown
exceptional
potential
as
carriers,
enabling
safe
controlled
local
delivery.
The
challenges
translate
MOF
therapies
clinical
use
require
not
only
validate
mechanisms
action
pathways
released
but
also
get
a
deep
understanding
into
rational
design,
it
requires
combination
features
maximize
outcomes.
In
this
perspective,
we
outline
key
criteria
designing
MOFs
delivery
applications
highlight
expanding
range
opportunities
materials
may
offer.
Readers
insights
design
develop
gasotransmitter
with
realistic
clinic
interest.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 5, 2025
Conservative
anti-cancer
treatment
represented
by
chemotherapy
and
surgery
lacks
tumor-specificity
could
hardly
resolve
the
problems
associated
with
multidrug
resistance
(MDR)
in
cancers.
Novel
therapeutic
materials
cancer
treatment,
such
as
those
anti-MDR
or
controllable
features,
represent
a
significant
trend
due
to
their
advantages
of
high
specific
efficacy
timely
intervention
progress.
In
addition
excellent
biocompatibility
specificity,
they
can
be
utilized
therapies
that
require
ease
operation,
provided
are
designed
detection
sensitivity.
this
review,
we
summarize
series
recently
developed
exhibit
these
advantages,
including
immune-enhancing
tumor
microenvironment
(TME)-
responsive
materials,
integrated
imaging
capabilities.
We
also
introduce
advanced
modification
approaches
impart
essential
targeting
functionalities
materials.
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Pine
wilt
disease
is
caused
by
Bursaphelenchus
xylophilus
invasion
and
has
a
great
impact
on
global
pine
resources.
Injection
of
emamectin
benzoate
(EB)
into
trunks
an
effective
way
to
control
B.
xylophilus.
However,
EB
limited
aqueous
solubility,
easily
photodissociates,
its
long-term
use
causes
resistance
problems.
In
this
study,
the
metal-organic
framework
material
ZIF-8
was
prepared,
loaded
onto
through
physical
adsorption,
resulting
in
pH-responsive
EB@ZIF-8
nanopesticide
with
high
drug
loading
rate
(36.04%).
Simulated
release
experiments
under
different
pH
conditions
showed
cumulative
64.43%
within
10
h
at
5.0,
which
increased
as
decreased,
compared
7.0
9.0.
positive
insecticidal
activity
laboratory
biological
test
(LC50
=
52.503
mg/L).
addition,
7
days
after
trunk
injection
Pinus
massoniana,
residuals
were
detected
all
parts
branches,
lowest
residue
level
being
73.39
mg/kg.
The
proportion
lower,
middle,
upper
branches
P.
massoniana
gradually
increased,
reaching
43.92%
28
injection,
indicating
that
distributed
evenly
tree.
Therefore,
had
good
morphology,
structure,
performance.
also
exhibited
nematocidal
ability
due
smaller
particle
size
rapid
transport
massoniana.
This
study
provides
new
approach
for
development
highly
preparations,
improvement
pesticide
utilization,
control.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Gas
therapy
using
gasotransmitters
is
of
exponential
interest
due
to
the
growing
recognition
gas
signaling
molecules
that
can
be
involved
in
multiple
therapeutic
actions.
Finding
suitable
methods
for
delivering
these
crucial,
and
porous
materials,
notably
metal-organic
frameworks
(MOFs),
have
shown
exceptional
potential
as
carriers,
enabling
safe
controlled
local
delivery.
The
challenges
translate
MOF
therapies
clinical
use
require
not
only
validate
mechanisms
action
pathways
released
but
also
get
a
deep
understanding
into
rational
design,
it
requires
combination
features
maximize
outcomes.
In
this
perspective,
we
outline
key
criteria
designing
MOFs
delivery
applications
highlight
expanding
range
opportunities
materials
may
offer.
Readers
insights
design
develop
gasotransmitter
with
realistic
clinic
interest.
