A 3D printable gelatin methacryloyl/chitosan hydrogel assembled with conductive PEDOT for neural tissue engineering

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 273, P. 111241 - 111241

Published: Jan. 24, 2024

Language: Английский

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Mechanical Stimulation of Anti‐Inflammatory and Antioxidant Hydrogels for Rapid Re‐Epithelialization

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)

Published: Jan. 26, 2024

Abstract The epithelium, an essential barrier to protect organisms against infection, exists in many organs. However, rapid re‐epithelialization restore tissue integrity and function adverse environment is challenging. In this work, a long‐term anti‐inflammatory antioxidant hydrogel with mechanical stimulation for re‐epithelialization, mainly composed of the small molecule thioctic acid, biocompatible glycine, γ‐Fe 2 O 3 nanoparticles reported. Glycine‐modified supramolecular acid stable possesses outstanding properties. incorporating providing potential contrast magnetic resonance imaging observation, can propel reconfiguration enhance properties underwater due water‐initiated release Fe 3+ . vitro experiments show that hydrogels effectively reduced intracellular reactive oxygen species, guided macrophages toward M2 polarization, alleviated inflammation. effect ultimately demonstrated long urethral injury model vivo, achieves effective functional replacement accurate remodeling epithelium. Notably, proposed strategy provides advanced alternative treatment patients need large‐area epithelial reconstruction.

Language: Английский

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Interventional Hydrogel Microsphere Controlled‐Releasing Curcumin for Photothermal Therapy against Endometriosis

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)

Published: Feb. 23, 2024

Abstract Endometriosis is a prevalent gynecological disorder characterized by the presence of endometrial‐like tissue outside uterus, causing chronic pelvic pain, painful periods, and infertility. Despite common use hormone therapy surgical lesion excision in its treatment, there remain significant postoperative risks potential side effects, with high recurrence rate. An efficient nonsurgical treatment for this condition therefore urgently needed. In study, an interventional hydrogel microsphere near‐infrared (NIR)‐controlled curcumin release developed non‐invasive thermal endometriosis. The microspheres demonstrate good biocompatibility photothermal activities, death endometrial stromal cells under NIR controlled (Cur) release. When injected into endometriotic lesions stimulated light, (Cur‐FeHMPs) can raise temperature to 43.65 °C, inducing elimination. Furthermore, from inhibits proinflammatory environment Cur‐FeHMPs combination present novel strategy endometriosis treatment.

Language: Английский

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Injectable chitosan microspheres resisting inflammatory and oxidative stress for ameliorating intervertebral disc degeneration

Science China Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

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Bi-layered hydrogel conduit integrating microneedles for enhanced neural recording and stimulation therapy in peripheral nerve injury repair

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 413, P. 135917 - 135917

Published: May 3, 2024

Language: Английский

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Hydrogels for Neural Regeneration: Exploring New Horizons

Materials, Journal Year: 2024, Volume and Issue: 17(14), P. 3472 - 3472

Published: July 13, 2024

Nerve injury can significantly impair motor, sensory, and autonomic functions. Understanding nerve degeneration, particularly Wallerian the mechanisms of regeneration is crucial for developing effective treatments. This manuscript reviews use advanced hydrogels that have been researched to enhance regeneration. Hydrogels, due their biocompatibility, tunable properties, ability create a supportive microenvironment, are being explored effectiveness in repair. Various types hydrogels, such as chitosan-, alginate-, collagen-, hyaluronic acid-, peptide-based discussed roles promoting axonal growth, functional recovery, myelination. Advanced formulations incorporating growth factors, bioactive molecules, stem cells show significant promise overcoming limitations traditional therapies. Despite these advancements, challenges achieving robust reliable remain, necessitating ongoing research optimize hydrogel-based interventions neural

Language: Английский

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Bioactive Nb₂C MXene‐Functionalized Hydrogel with Microenvironment Remodeling and Enhanced Neurogenesis to Promote Skeletal Muscle Regeneration and Functional Restoration

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract The complete structure‐functional repair of volumetric muscle loss (VML) remains a giant challenge and biomedical hydrogels to remodel microenvironment enhance neurogenesis have appeared be promising direction. However, the current for VML hardly achieve these two goals simultaneously due their insufficient functionality in high‐cost bioactive factors. In this study, facile strategy using Nb 2 C MXene‐functionalized hydrogel (OPTN) as scaffold is proposed promote with skeletal regeneration functional restoration. vitro experiments show that OPTN can effectively scavenge reactive oxygen species (ROS), guide macrophages polarization toward M2 phenotype, resist bacterial infection, providing favorable myoblasts proliferation well endothelial cells proliferation, migration, tube formation. More importantly, electroactive feature remarkably boosts differentiation mesenchymal stem neural differentiation. Animal further confirm prominent by attenuating ROS levels, alleviating inflammation, reducing fibrosis, facilitating angiogenesis, newborn myotube formation, neurogenesis. Collectively, study provides highly effective through designing multifunctional remodeling enhanced

Language: Английский

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Recent Advances in Conductive Hydrogels for Soft Biointegrated Electronics: Materials, Properties, and Device Applications

Wearable electronics., Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Protective effects of indole-3-propionic acid against TCP-induced hearing loss in mice by mitigating oxidative stress and promoting neutrophil recruitment

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 19, 2025

Sensorineural hearing loss (SNHL) poses a significant global health challenge with substantial socioeconomic and medical implications. The pathophysiology involves excessive reactive oxygen species (ROS) in the cochlea, inflammation, cellular apoptosis, etc. Tryptophan metabolite indole-3-propionic Acid (IPA), produced by gut microbiota, may offer therapeutic benefits modulating oxidative stress, immune responses. However, roles of IPA protecting from treatment adult mice remain to be investigated. We previously validated that exposure pesticide 3, 5, 6-Trichloro-2-pyridinol (TCP) caused mice. Herein, continuous administration 40 mg/kg for 21 days significantly attenuated threshold elevation C57BL/6 exposed 50 TCP. reduced hair cells (HCs) spiral ganglion neurons (SGNs), preserved nerve fibers, reversed damage ligaments (SL) stria vascularis (SV). Similarly, cotreatment decreased ROS accumulation cochlea inhibited HC SGN apoptosis. Transcriptomic analysis showed enhanced responses, particularly through neutrophil recruitment activation regenerative signals like IFNγ. These findings underscore IPA's protective effects against TCP-induced loss, highlighting role mechanisms cochlear protection.

Language: Английский

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Conductive Hydrogels as an “Innovative Healer” for the treatment of diabetic wounds

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 8(18), P. 2944 - 2977

Published: Jan. 1, 2024

Conductive hydrogels, with their electrical stimulation effects and properties, are potential candidates for treating diabetic wounds.

Language: Английский

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