Photo-controlled multifunctional hydrogel for photothermal sterilization and microenvironment amelioration of infected diabetic wounds DOI
Fan Yang,

Dong Mo,

Beibei Wu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 470 - 484

Published: Nov. 29, 2024

Language: Английский

Covalent Organic Framework: A Rising Star in Antibacterial Agents DOI Open Access

Luo‐Gang Ding,

Minmin Shi, Yulin Xu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract In the face of escalating antibiotic resistance crisis, world is embroiled in a silent “antibacterial war”. Scientists are actively searching for innovative antibacterial materials that can be used as effective weapons against bacterial infections. As promising new crystalline porous polymer materials, covalent organic frameworks (COFs) gradually revealing their vast potential applications. This study investigates classification COF‐based agents, provides comprehensive overview applications and research advancements, explores strategies employed by COF materials. Furthermore, challenges outlined lie ahead future application agents insights into prospects within field offered. Through these efforts, aim to accelerate advancements COFs manufacturing technology, promote innovation applications, contribute public health.

Language: Английский

Citations

1
A self-powered, implantable bone-electronic interface for home-based therapeutic strategy of bone regeneration DOI

Chuanhang Xu,

Shan Liang,

Dongqi Fan

et al.

Nano Energy, Journal Year: 2024, Volume and Issue: 124, P. 109470 - 109470

Published: March 12, 2024

Language: Английский

Citations

5
Polyvalent copper oxide nanozymes: Co-delivery of ROS and NO for inducing cuproptosis-like bacterial death against MRSA infections DOI

Xufeng Zhu,

Jinjun Chen,

Binhua Wu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 499, P. 156507 - 156507

Published: Oct. 9, 2024

Language: Английский

Citations

5
“Disguise strategy” to bacteria: A multifunctional hydrogel with bacteria-targeting and photothermal conversion properties for the repair of infectious bone defects DOI
Kexin Li, En Xie, Chengyuan Liu

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 343 - 360

Published: Feb. 12, 2025

Language: Английский

Citations

0
Near-infrared light-responsive nanocomposite hydrogels loaded with epidermal growth factor for diabetic wound healing DOI Creative Commons
Miao Li,

Xue Feng Lu,

Yaoyao Wei

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101578 - 101578

Published: Feb. 14, 2025

In diabetic wounds, the presence of hyperglycemia is often accompanied by a persistent inflammatory response, oxidative stress damage, impaired angiogenesis and bacterial infections around wound, resulting in proliferation dermal epidermal cells skin regeneration wounds. To solve above problems, this study designed near-infrared (NIR) light-responsive multifunctional poloxamer hydrogel (EGF/PDA-MXene Gel). The Gel composed two-dimensional nanomaterials (2D NMs) MXene as core, modified polymer, further loaded with growth factor (EGF), has antibacterial, antioxidant, photothermal properties. Meanwhile, EGF/PDA-MXene can be used drug repository, alleviating problem short half-life, realizing sustained release EGF. NIR property induces protein denaturation leading to death pathogenic bacteria, avoiding common clinical antibiotic resistance. addition, promotes chronic wound healing promoting regeneration, collagen deposition, angiogenesis, several other mechanisms. Therefore, preparation strategies that combine bioactive molecules 2D NMs, which maintains activity EGF while exploiting antimicrobial advantages NMs photothermally, provide new promising therapeutic approach for accelerating repair infected

Language: Английский

Citations

0
Biomedical Engineering on Smart Polymeric Nanoparticle–Hydrogel Platforms for Efficient Antibiotic Delivery against Bacterial-Infected Wounds DOI
Jiahao Xu,

Dongzhe Zou,

Edward Dong

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

The rising incidence of bacterial infections poses a significant challenge to global public health. development safe and effective antibacterial treatment strategies is an urgent need in the field biomedicine. In this work, we developed smart nanoparticle-hydrogel platform address wounds. Rifampicin-loaded chitosan-functionalized nanoparticles (R-CNP) could break barriers enhance antibiotic internalization. R-CNP reduced minimum inhibitory concentration rifampicin against Staphylococcus aureus greatly enhanced bactericidal effect rifampicin. Furthermore, was incorporated into thermosensitive hydrogels (HG) construct HG(R-CNP) for accumulation wound protection. mouse model with bacterial-infected wound, content by 98.5% as compared free Therefore, constructed FDA-approved or natural polymers, offers therapeutic efficacy on wounds, showing great promise clinical translation.

Language: Английский

Citations

0
Construction of multifunctional gauze via the potassium permanganate method for wound management DOI
Wei Zhang,

Qiang Niu,

Yuyang Cheng

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161541 - 161541

Published: March 1, 2025

Language: Английский

Citations

0
Anti-MRSA and cytotoxic activity of a new diamide compound isolated from Aspergillus sp. H30 DOI

Long-Fen Li,

Yingying Hu, Xinzhu Wang

et al.

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 7

Published: March 17, 2025

A new aromatic diamide compound, aspergillusin (1), together with three known compounds, globosterol (2), ergosterol (3), and cladosporide (4), was isolated from the crude extract of endophytic fungi Aspergillus sp. H30. The structures were elucidated using NMR MS data, finally, biosynthetic pathway compound 1 hypothesised. Compounds 1–4 tested for their antibacterial activities on six pathogenic bacteria also evaluated against human non-small cell lung cancer H1299. Among them, exhibited weak activity MRSA a strong effect bronchial epithelial line, BEAS-2B, an IC50 value 12.32 ± 0.37 μM.

Language: Английский

Citations

0
Bacteria-Responsive Drug Delivery System Utilizing Carboxymethyl Cellulose-Functionalized Metal–Organic Framework for Enhanced Antibacterial Efficacy DOI
Pingping Yuan,

M. Zhang,

Sheng Wang

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Bacterial infections pose a significant threat to human health and economic stability. The overuse of antibiotics has exacerbated bacterial resistance, highlighting the urgent need for innovative strategies combat this issue. Bacteria-responsive drug delivery systems present promising solution overcoming resistance. Metal-organic frameworks (MOFs), versatile porous materials created by linking metal clusters with organic ligands, are ideal candidates such applications. Here, we employed zeolite imidazole framework 8 (ZIF-8) as carrier ceftiofur (EFT), enhanced carboxymethyl cellulose develop smart system (CMC-EFT@ZIF-8) responsive pH cellulase. In vitro tests demonstrated that released higher quantity EFT under acidic conditions in presence cellulase, leading more effective disruption membranes subsequent death. CMC-EFT@ZIF-8 achieved 99% clearance Pseudomonas aeruginosa within 6 h showed superior efficacy mouse skin wound model. These findings underscore potential our significantly improve treatment outcomes infections, representing advancement fight against antibiotic

Language: Английский

Citations

0
Dual osmotic controlled release platform for antibiotics to overcome antimicrobial-resistant infections and promote wound healing DOI

Wanni Cai,

Yan Song,

Qing Lin Xie

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 627 - 642

Published: Sept. 23, 2024

Language: Английский

Citations

3