Amplifying Ca2+ Overload by Engineered Biomaterials for Synergistic Cancer Therapy DOI
Jun‐Long Liang, Yangyang Cao, Kangle Lv

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123027 - 123027

Published: Dec. 15, 2024

Language: Английский

Dual-Enzyme-Instructed Peptide Self-Assembly to Boost Immunogenic Cell Death by Coordinating Intracellular Calcium Overload and Chemotherapy DOI
H. H. Zhang, Yuhan Hu,

Yinghao Ding

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 488 - 503

Published: Jan. 4, 2025

The concept of immunogenic cell death (ICD) induced by chemotherapy as a potential synergistic modality for cancer immunotherapy has been widely discussed. Unfortunately, most chemotherapeutic agents failed to dictate effective ICD responses due their defects in inducing potent signaling. Here, we report dual-enzyme-instructed peptide self-assembly platform CPMC (CPT-GFFpY-PLGVRK-Caps) that cooperatively utilizes camptothecin (CPT) and capsaicin (Caps) promote engage systemic adaptive immunity tumor rejection. Although CPT Caps respectively prevent progression inhibiting type-I DNA topoisomerase activating transient receptor cation channel subfamily V member 1 (TRPV1) intracellular calcium overload, neither alone effectively stimulates sufficient signaling meet immunotherapeutic needs. CPMC, sequentially allowing an active derivative VRK-Caps release extracellularly intracellularly, can synergize two distinct apoptosis pathways stimulated increase immunogenicity elicit T-cell-based immunity. Consequently, facilitates the generation improved tumor-specific cytotoxic T-cell sustained immunological memory, successfully suppressing both primary distant tumors. Moreover, render tumors susceptible PD-L1 blockade with antiprogrammed death-ligand (aPDL1) antibody inhibition. Combining drugs low ICD-stimulating capacity using strategy was demonstrated boost potentiate immunotherapy.

Language: Английский

Citations

1
Hyaluronic acid-mediated targeted nano-modulators for activation of pyroptosis for cancer therapy through multichannel regulation of Ca2+ overload DOI
Linwei Li,

Zihan Xing,

Jinyu Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140116 - 140116

Published: Jan. 20, 2025

Language: Английский

Citations

0
Copper-based hollow mesoporous nanogenerator with reactive oxygen species and reactive nitrogen species storm generation for self-augmented immunogenic cell death-mediated triple-negative breast cancer immunotherapy DOI
Quan Jing, Jinlong Zhang,

L. Yuan

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 688, P. 688 - 702

Published: Feb. 27, 2025

Language: Английский

Citations

0
Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy DOI
Zhen Liu, Wei Hu, Yingying Cai

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 690, P. 137332 - 137332

Published: March 14, 2025

Language: Английский

Citations

0
A Self‐Delivery Nanodrug Simultaneously Inhibits COX‐2/PGE2 Mediated Inflammation and Downregulates PD‐L1 to Boost Photoimmunotherapy DOI
Jinmei Lai, Peiling Chen,

Qun‐Ying Shi

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: May 5, 2024

Abstract Phototherapy promotes anti‐tumor immunity by inducing immunogenic cell death (ICD), However, the accompanying inflammatory responses also trigger immunosuppression, attenuating efficacy of photo‐immunotherapy. Herein, they co‐assembled a cell‐membrane targeting chimeric peptide C16‐Cypate‐RRKK‐PEG 8 ‐COOH (CCP) and anti‐inflammatory diclofenac (DA) to develop nanodrug (CCP@DA) that both enhances immune effect phototherapy weakens inflammation‐mediated immunosuppression. CCP@DA achieves membrane‐targeting photodynamic photothermal synergistic therapies damage programmed ligand 1 (PD‐L1) induce strong ICD activate response. Simultaneously, released DA inhibits cycoperoxidase‐2 (COX‐2)/prostaglandin E2 (PGE 2 ) pathway in tumor cells inhibit pro‐tumor inflammation further down‐regulate PD‐L1 expression relieve immunosuppressive microenvironment. significantly inhibited growth vitro vivo, while maintaining potent Additionally, it exhibits excellent anti‐metastatic capabilities prolongs mouse survival time with single dose low levels near‐infrared (NIR) light exposure. This work provides valuable strategy control therapy‐induced for high‐efficiency photoimmunotherapy.

Language: Английский

Citations

3
Acidity-Responsive Fe-PDA@CaCO3 Nanoparticles for Photothermal-Enhanced Calcium-Overload- and Reactive-Oxygen-Species-Mediated Tumor Therapy DOI
Fan Zhao, Chen Wang, Heng Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(33), P. 43364 - 43373

Published: Aug. 6, 2024

Calcium-overload-mediated tumor therapy has received considerable interest in oncology. However, its efficacy been proven to be inadequate due insufficient calcium ion concentration at the site coupled with challenges facilitating efficient uptake by tumors, leading unsatisfactory therapeutic outcomes. In present study, carbonate nanoshell mineralized ferric polydopamine nanoparticles (Fe-PDA@CaCO

Language: Английский

Citations

2
A nanotheranostics with hypoxia-switchable fluorescence and photothermal effect for hypoxia imaging-guided immunosuppressive tumor microenvironment modulation DOI
Xudong Li,

Xianbin Sun,

Ya Wang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 678, P. 897 - 912

Published: Sept. 20, 2024

Language: Английский

Citations

2
A morphologically transformable hypoxia-induced radical anion for tumor-specific photothermal therapy DOI Creative Commons
Hongyu Wang,

Dengyuan Hao,

Qihang Wu

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5407 - 5417

Published: Sept. 21, 2024

Tumor microenvironment activatable therapeutic agents and their effective tumor accumulation are significant for selective treatment. Herein, we provide an unadulterated nanomaterial combining the above advantages. We synthesize a perylene diimide (PDI) molecule substituted by glutamic acid (Glu), which can self-assemble into small spherical nanoparticles (PDI-SG) in aqueous solution. PDI-SG not only be transformed nanofibers at low pH conditions but also reduced to PDI radical anion (PDI·‒), exhibits strong near-infrared absorption excellent photothermal performance. More importantly, PDI·‒ hypoxic tumors ablate minimize damage normal tissues. The morphological transformation from makes better retention. This work sheds light on design of therapeutics with precise structures high-performance therapy.

Language: Английский

Citations

1
Mild photothermal activation of TRPV1 pathway for enhanced calcium ion overload therapy of hepatocellular carcinoma DOI

Liya Yu,

Longcai Liu,

Yehui Kang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137192 - 137192

Published: Nov. 1, 2024

Language: Английский

Citations

1
Engineering of calcium overload for state-of-the-art tumor therapy DOI
Xinping Liu, Hui Hu, Jinjin Chen

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 501, P. 157747 - 157747

Published: Nov. 17, 2024

Language: Английский

Citations

1