CO-loaded Hemoglobin/EGCG Nanoparticles Functional Coatings for Inflammation Modulation of Vascular Implants DOI Creative Commons

Sui Wu,

Ruifang Dong,

Yinhong Xie

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 20, 2024

Abstract During the implantation process of cardiovascular implants, vascular damage caused by inflammation occurs, and inflammatory is accompanied oxidative stress. Currently, carbon monoxide (CO) has been demonstrated to exhibit various biological effects including vasodilatation, antithrombotic, anti-inflammatory, apoptosis-inducing antiproliferative properties. In this study, hemoglobin/epigallocatechin-3-gallate (EGCG) core-shell nanoparticle-containing coating on stainless steel was prepared for CO loading modulation. Inspired strong coordination ability with CO, hemoglobin nanoparticle first encapsulated into EGCG metal-phenolic networks. A polydopamine (PDA) linking layer then coated 316 steel, hemoglobin/EGCG nanoparticles were loaded subsequent PDA deposition. It showed that maximum release amount 17.0 nmol/cm2 in 48 h. vitro evaluations conducted a simulated environment revealed coating, which released from nanoparticles, effectively mitigated lipopolysaccharide-induced response macrophages. Specifically, it decreased expression tumor necrosis factor-α, increased interleukin-10, suppressed polarization macrophages toward M1 phenotype reduced intracellular reactive oxygen species (ROS). Furthermore, under stress conditions, apoptosis endothelial cells induced down-regulated ROS levels. vivo results further confirmed its capabilities, macrophage-mediated responses modulated

Language: Английский

“Synergistic anticoagulant and endothelial regeneration strategy” based on mussel-inspired phospholipid copolymer coating and bioactive zeolitic imidazolate frameworks-90 to maintain the patency of CoCr stent DOI
Wen Liu, Ye Wan, Xiaoyu Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 135842 - 135842

Published: Sept. 20, 2024

Language: Английский

Citations

0
CO-loaded Hemoglobin/EGCG Nanoparticles Functional Coatings for Inflammation Modulation of Vascular Implants DOI Creative Commons

Sui Wu,

Ruifang Dong,

Yinhong Xie

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 20, 2024

Abstract During the implantation process of cardiovascular implants, vascular damage caused by inflammation occurs, and inflammatory is accompanied oxidative stress. Currently, carbon monoxide (CO) has been demonstrated to exhibit various biological effects including vasodilatation, antithrombotic, anti-inflammatory, apoptosis-inducing antiproliferative properties. In this study, hemoglobin/epigallocatechin-3-gallate (EGCG) core-shell nanoparticle-containing coating on stainless steel was prepared for CO loading modulation. Inspired strong coordination ability with CO, hemoglobin nanoparticle first encapsulated into EGCG metal-phenolic networks. A polydopamine (PDA) linking layer then coated 316 steel, hemoglobin/EGCG nanoparticles were loaded subsequent PDA deposition. It showed that maximum release amount 17.0 nmol/cm2 in 48 h. vitro evaluations conducted a simulated environment revealed coating, which released from nanoparticles, effectively mitigated lipopolysaccharide-induced response macrophages. Specifically, it decreased expression tumor necrosis factor-α, increased interleukin-10, suppressed polarization macrophages toward M1 phenotype reduced intracellular reactive oxygen species (ROS). Furthermore, under stress conditions, apoptosis endothelial cells induced down-regulated ROS levels. vivo results further confirmed its capabilities, macrophage-mediated responses modulated

Language: Английский

Citations

0