Coatings,
Journal Year:
2024,
Volume and Issue:
14(9), P. 1229 - 1229
Published: Sept. 23, 2024
Biomimetic
hydrogel
lubrication
coatings
with
high
wettability
and
low
friction
show
great
promise
in
tissue
engineering,
wound
dressing,
drug
delivery,
intelligent
sensing.
Inspired
by
the
hierarchical
structure
of
natural
cartilage,
a
layered
coating
was
constructed
to
functionalize
rigid
polyetheretherketone
(PEEK).
The
features
structural
design
comprising
top
soft
layer
middle
robust
layer.
porous
stores
water
molecules,
providing
surface
lubrication,
while
dense
offers
load-bearing
capacity.
These
synergistic
effects
gradient
endow
PEEK
substrate
an
ultra-low
coefficient
(COF~0.010
at
5
N
load),
good
capacity
(COF~0.031
10
excellent
wear
resistance
(COF
<
0.05
load
after
20,000
sliding
cycles).
This
study
introduces
novel
paradigm
for
exceptional
lubricity,
displaying
potential
application
cartilage
replacement
materials.
Enzymes
are
promising
biocatalysts
due
to
their
high
efficiency,
mild
conditions,
specificity,
nontoxicity,
and
environmental
friendliness.
However,
the
enzyme
suffers
from
poor
stability
reusability.
Enzyme
immobilization
is
a
commonly
used
technology
enhance
its
In
this
study,
cellulose
nanocrystal
(CNC)
was
chosen
as
carrier
sustainability,
specific
surface
area,
biocompatibility,
water
dispersibility,
excellent
Pickering
emulsifying
ability.
Lipase
immobilized
on
polydopamine-coated
CNC
(PC),
obtained
lipase-immobilized
PC
(LPC)
displayed
significantly
enhanced
higher
activity
in
harsh
conditions
compared
free
lipase.
LPC
possessed
partial
wettability
with
both
oil
phases
lower
absolute
value
of
zeta
potential
than
CNC,
endowing
it
better
ability
CNC.
fixed
at
oil–water
interface
emulsion
by
ultrasonication,
resulting
droplets
were
employed
microreactors
for
ester
hydrolysis
synthesis
via
biocatalysis.
catalysis
lipase
traditional
biphasic
system
increased
contact
area
between
substrate,
reduced
diffusion
distance
activation
effect.
Moreover,
could
be
facilely
recycled
centrifugation,
still
retains
activity.
This
study
proposed
facile
sustainable
method
reusability
achieved
Small,
Journal Year:
2024,
Volume and Issue:
20(43)
Published: June 20, 2024
Abstract
Lubricating
hydrogel
coatings
on
inert
rubber
and
plastic
surfaces
significantly
reduce
friction
wear,
thus
enhancing
material
durability
lifespan.
However,
achieving
optimal
hydration
lubrication
typically
requires
a
porous
polymer
network,
which
unfortunately
reduces
their
mechanical
strength
limits
applicability
where
robust
wear‐resistance
are
essential.
In
the
research,
coating
with
remarkable
wear
resistance
surface
stability
is
developed
by
forming
semi‐interpenetrating
network
substrate
at
interface.
By
employing
good
solvent
swelling
method,
monomers,
photoinitiators
embedded
within
substrates'
subsurface,
followed
in
situ
polymerization
under
ultraviolet
light,
creating
entangled
structure.
This
approach,
offering
thicker
energy‐dissipating
layer,
outperforms
traditional
modifications
while
preserving
anti‐fatigue,
hydrophilicity,
oleophobicity,
other
properties.
Adaptable
to
various
substrates
using
suitable
solvents,
this
method
provides
an
efficient
solution
for
durable,
lubricating
surfaces,
broadening
potential
applications
multiple
industries.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 7, 2025
Abstract
Implant‐associated
infections
are
the
most
critical
threat
to
orthopedic
surgeries.
Various
surface‐modification
strategies
developed
impart
antibacterial
properties
and
osteogenesis‐promoting
abilities
surfaces
of
implants.
Nevertheless,
a
straightforward
strategy
for
constructing
functional,
stable,
bioactive
implant
surface
remains
challenging.
Here,
facile
one‐step
surface‐bioactivation
method
is
that
enhances
both
anti‐infection
capabilities
osteointegration
performance
This
approach
utilized
kind
coating
integrates
agents
components
directly
onto
titanium
The
cationic
agent
bone‐adhesion‐enhancing
peptide
covalently
attached
via
Michael
reaction
poly
(tannic
acid)
(PTA)
create
dual‐functional
implants
(Ti‐PR).
Ti‐PR
effectively
eliminated
more
than
99%
common
pathogenic
bacteria
significantly
enhanced
osteogenic
differentiation
bone
marrow
mesenchymal
stem
cells
(BMSCs)
in
vitro.
cell‐bacteria
competitive
culture
assay
on
confirms
its
bactericidal
cell
proliferation‐promoting
properties.
Additionally,
RNA‐Seq
analysis
indicated
PI3K/Akt
pathways
played
crucial
role
enhancing
BMSCs.
superior
osteogenesis
performances
confirmed
an
implant‐related
infection
model
vivo.
study
provided
efficient
design
production
innovative
multifunctional
The
prevalence
of
heart
valve
disease
(HVD)
has
escalated
worldwide,
because
population
aging.
Currently,
artificial
replacement
is
considered
the
most
effective
treatment
for
HVD.
complexity
and
risk
have
been
markedly
reduced
with
development
minimally
invasive
interventional
techniques,
which
resulted
in
more
widespread
implantation
bioprosthetic
valves
(BHVs);
however,
they
still
present
defects
including
thrombosis,
poor
cytocompatibility,
immune
responses,
calcification,
reduces
their
service
life.
We
developed
a
microenvironment-responsive
zwitterionic
glycocalyx-mimetic
hydrogel-engineered
BHV
(Hes@HS-PP)
profile
on-demand
drug
release.
Inspired
by
structure
function
glycocalyx
on
inner
wall
blood
vessels,
hydrogel
coating
was
covalently
constructed
photoinduced
polymerization.
This
significantly
resisted
fouling
components
thrombosis
improved
endothelialization
potential
biocompatibility
BHVs
shielding
interactions
between
xenogeneic
collagenous
matrix.
Following
introduction
dynamic
borate
ester
bonds
into
hydrogel,
anti-inflammatory
hesperidin
(Hes)
loaded
onto
BHVs.
Excess
reactive
oxygen
species
were
scavenged,
Hes
released
inflammatory
region
demand
to
achieve
regulation
ameliorate
reactions
Moreover,
Hes@HS-PP
exhibited
lower
degree
calcification
rat
subcutaneous
model.
In
summary,
construction
hydrogels
enhanced
antithrombotic,
anti-inflammatory,
endothelialization,
anticalcification
properties
mitigated
structural
valvular
degradation,
offering
new
perspectives
functional
modification
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
Cell
membrane
coating
has
emerged
as
a
promising
strategy
for
the
surface
modification
of
biomaterials
with
biological
membranes,
serving
cloak
that
can
carry
more
functions.
The
cloaked
inherit
diverse
intrinsic
biofunctions
derived
from
different
cell
sources,
including
enhanced
biocompatibility,
immunity
evasion,
specific
targeting
capacity,
and
immune
regulation
regenerative
microenvironment.
characteristics
biomimicry
biointerfacing
have
demonstrated
versatility
technology
on
variety
biomaterials,
thus,
furthering
research
into
wide
range
biomedical
applications
clinical
translation.
Here,
preparation
coatings
is
emphasized,
sizes
coated
nanoscale
to
macroscale
well
engineering
strategies
introduce
additional
are
summarized.
Subsequently,
utilization
biomimetic
membrane-cloaked
in
discussed,
drug
delivery,
imaging
phototherapy,
cancer
immunotherapy,
anti-infection
detoxification,
implant
modification.
In
conclusion,
latest
advancements
preclinical
studies,
along
multiple
benefits
membrane-coated
nanoparticles
(NPs)
systems,
elucidated.
