Applications of Nanotheranostic in the Second Near-Infrared Window in Bioimaging and Cancer Treatment

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Achieving accurate and efficient tumor imaging is crucial in the field of treatment, as it facilitates early detection precise localization tissues, thereby informing therapeutic strategies surgical interventions. The optical technology within second near-infrared (NIR-II) window has garnered significant interest for its remarkable benefits, such enhanced tissue penetration depth, superior signal-to-background ratio (SBR), minimal autofluorescence, reduced photon attenuation, lower scattering. This review explained design optimization nano-agents responsive to NIR-II window, single-walled carbon nanotubes, quantum dots, lanthanum-based nanomaterials, noble metal nanomaterials. These enable non-invasive, deep-tissue with high spatial resolution their properties significantly improve accuracy, efficiency, versatility imaging-guided treatments. And we discussed characteristics advantages fluorescence (FL)/photoacoustic (PA) providing a comprehensive overview latest research progress different FL/PA therapy. Furthermore, exhaustively reviewed applications multifunctional nano-phototherapy technologies carried out by light including photothermal therapy (PTT), photodynamic (PDT), combined modalities like photothermal-chemodynamic (PTT-CDT), photothermal-chemotherapy (PTT-CT), photothermal- immunotherapy (PTT-IO). integrated approaches have gradually matured over past decade are expected become safe effective non-invasive treatment. Finally, outlined prospects challenges development innovation diagnosis nanoplatform. aims provide insightful perspectives future advancements treatment platforms.

Language: Английский

Ultrasensitive NIR‐II Surface‐Enhanced Resonance Raman Scattering Nanoprobes with Nonlinear Photothermal Effect for Optimized Phototheranostics

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Abstract Surface‐enhanced resonance Raman scattering (SERRS) in the second near‐infrared (NIR‐II) window has great potential for improved phototheranostics, but lacks nonfluorescent, resonant and high‐affinity dyes. Herein, it is designed synthesize a multi‐sulfur reporter, NF1064, whose maximum absorption of 1064 nm rigidly resonates with NIR‐II excitation laser while possessing absolutely nonfluorescent backgrounds. Ultrafast spectroscopy suggests that fluorescence quenching mechanism NF1064 originates from twisted intramolecular charge transfer (TICT) excited state. Gold nanorods (AuNRs) decorated such (AuNR@NF1064) show remarkable SERRS performances, including zero‐fluorescence background, femtomolar‐level sensitivity as well superb photostability without photobleaching. More importantly, AuNR@NF1064 exhibits nonlinear photothermal effect upon plasmonic fields AuNRs by amplifying non‐radiative decay thus achieving high conversion 68.5% further augmentation. With properties, nanoprobes allow high‐precision intraoperative guided tumor resection within 8 min, high‐efficient hyperthermia combating drug‐resistant bacterial infection living mouse body. This work not only unlocks dyes imaging, also opens up new method boosting efficiency nanomaterials.

Language: Английский