Metabolizable alloy clusters assemble nanoinhibitor for enhanced radiotherapy of tumor by hypoxia alleviation and intracellular PD-L1 restraint DOI Creative Commons

Guanwen Ding,

Shengnan Liu, Xiangshan Yang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

Cancer radiotherapy (RT) still has limited clinical success because of the obstacles including radioresistance hypoxic tumors, high-dose X-ray–induced damage to adjacent healthy tissue, and DNA-damage repair by intracellular PD-L1 in tumor. Therefore, overcome these multifunctional core–shell BMS@Pt2Au4 nanoparticles (NPs) are prepared using nanoprecipitation followed electrostatic assembly. Pt2Au4 clusters released from NPs alleviate tumor hypoxia catalyzing decomposition endogenous H2O2 generate O2 as well enhancing X-ray deposition at site, which thereby reduce required dose. The BMS-202 molecules simultaneously blockade on cells, causing activation effector T cells inhibition repair. Consequently, based enhance expression calreticulin cancer transposition HMGB1 nucleus cytoplasm, generation reactive oxygen species (ROS), DNA breakage apoptosis vitro. rate reached 92.5% under three cycles 1-Gy irradiation vivo. In conclusion, therapeutic outcome supports high-efficiency tumors expressing PD-L1.

Language: Английский

Immunoadjuvant-Functionalized Metal-Organic Frameworks：Synthesis and Applications in Tumor Immune Modulation DOI
Chen Zhao, Weihua Song,

Jianing Wang

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

This review explores the synthesis, drug loading, and surface modifications of metal–organic frameworks (MOFs), highlighting their role in improving cancer immunotherapy paving way for safer more effective treatments.

Language: Английский

Citations

31
Selenium‐Doped Nanoheterojunctions for Highly Efficient Cancer Radiosensitization DOI Creative Commons

Rui Qiao,

Zhongwen Yuan,

Meijin Yang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(29)

Published: June 3, 2024

Abstract Exploring efficient and low‐toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression poor prognosis remains one critical developmental challenges in radiotherapy. Nanoheterojunctions, due their unique physicochemical properties, have demonstrated excellent radiosensitization effects energy deposition lifting tumor radiotherapy inhibition. Herein, they doped selenium (Se) into prussian blue (PB) construct a nano‐heterojunction (Se@PB), which could promote increase Fe 2+ /Fe 3+ ratio conversion Se high valence state with introduction. The ‐Se‐Fe electron transfer chain accelerates rate on surface nanoparticles, turn endows it X‐ray transport capability, enhances physical sensitivity. Furthermore, Se@PB induces glutathione (GSH) depletion accumulation pro‐Fenton reaction, thereby disturbs redox balance cells biochemical sensitivity As an radiosensitizer, effectively induced mitochondrial dysfunction DNA damage, promotes cell apoptosis synergistic cervical cancer This study elucidates mechanism Se‐doped nanoheterojunction from perspective biochemistry provides low‐toxic strategy

Language: Английский

Citations

13
Microgels-Encapsulated Magnesium/Emodin-based metal organic framework nanorods for diabetic bone regeneration DOI Creative Commons
Di Wang, Yajie Wang,

Daiying Song

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150585 - 150585

Published: March 20, 2024

Diabetic bone defect repair is one of the major challenges in clinic, because pathological microenvironments such as hyperglycemia, oxidative stress, and inflammation exist area diabetes mellitus. Although current tissue-engineered has achieved favorable regeneration functional reconstruction, it still unsatisfactory for diabetic only by correcting a single factor. In this study, we develop multifunctional nano-releasing system GelMA/HAMA microgels-encapsulated Mg2+/Emodin (MgEm) nanorods based on MOF design principle (denoted MEGH) reversing microenvironment. For slow-release MEGH microgels, Emodin exert hypoglycemic, antioxidant, anti-inflammatory function, while Mg2+ ions could promote angiogenesis regeneration. Subsequently, combine decalcified matrix with regenerative units BMSCs-loaded microgels (BMSCs@MEGH-D) construction bone. Finally, pre-constructed BMSCs@MEGH-D scaffolds successfully vascularized rabbit skull models due to effective correction The underlying mechanism indicates synergetic efficacy regulate glucose, inflammation, oxygen-related bioprocesses, well osteogenesis-related pathways. Our findings provide promising treatment microenvironment accelerate repair.

Language: Английский

Citations

10
Anaerobic Probiotics-in situ Se nanoradiosensitizers Selectively Anchor to Tumor with Immuno-regulations for Robust Cancer Radio-immunotherapy DOI
Yangyang Yu, Ying Wang, Jilei Zhang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123117 - 123117

Published: Jan. 21, 2025

Language: Английский

Citations

1
Bimetallic Coordination Polymers: Synthesis and Applications in Biosensing and Biomedicine DOI Creative Commons
Yanping Sun,

Jianxin Ma,

Faisal Ahmad

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(3), P. 117 - 117

Published: Feb. 22, 2024

Bimetallic coordination polymers (CPs) have two different metal ions as connecting nodes in their polymer structure. The synthesis methods of bimetallic CPs are mainly categorized into the one-pot method and post-synthesis modifications according to various needs. Compared with monometallic CPs, synergistic effects excellent properties, such higher gas adsorption rate, more efficient catalytic stronger luminescent stable loading platforms, which been widely applied fields adsorption, catalysis, energy storage well conversion, biosensing. In recent years, study synergized cancer drugs functional nanomaterials for therapy has increasingly attracted attention scientists. This review presents research progress biosensing biomedicine last five years provides a perspective future development.

Language: Английский

Citations

7
Advances in Nanodynamic Therapy for Cancer Treatment DOI Creative Commons
Bingchang Zhang, Yan Huang, Yong Huang

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(7), P. 648 - 648

Published: April 8, 2024

Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances tumor-specific targeting and selectivity leveraging the microenvironment (TME) mechanisms that boost immune responses. It also minimizes damage surrounding healthy tissues cytotoxicity cells, showing promise cancer treatment, with significant potential. This review covers research progress five major nanodynamic therapies: photodynamic (PDT), electrodynamic (EDT), sonodynamic (SDT), radiodynamic (RDT), chemodynamic (CDT), emphasizing role advanced nanotechnology development for purposes. The mechanisms, effects, challenges faced these NDTs are discussed, along their respective solutions enhancing efficacy, such as pH response, delivery, combined immunotherapy. Finally, this briefly addresses clinical translation NDT.

Language: Английский

Citations

7
Cell-Penetrating Peptide Functionalized ZIF-8 (Zn, Fe)/Doxorubicin/Chitosan-Grafted-Polycaprolactone/Curcumin Against A549 Lung Cancer Cells DOI

Hananeh Kordbacheh,

Sahand Eslami,

Aryan Rezaee

et al.

Journal of Polymers and the Environment, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Language: Английский

Citations

4
Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics DOI Creative Commons
Huayun Shi, Rafael C. Marchi, Peter J. Sadler

et al.

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).

Language: Английский

Citations

0
Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics DOI Creative Commons
Huayun Shi, Rafael C. Marchi, Peter J. Sadler

et al.

Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).

Language: Английский

Citations

0
[Ru(bpy)3]2+ Derivatives-Incorporated POM@MOFs with Good Photocatalytic Activity for Visible-Light-Driven Oxidative Coupling of Amines to Imines DOI
Zhen Jing,

Sen Liu,

Xiaodong Zhang

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Two novel POM@MOFs, {H3Zn2.5(H2O)10[Ru(dcbpy)3][PMo11VIMoVO40]}·2H2O (RuZn-PMo) and {H3Ni2.5(H2O)12[Ru(dcbpy)3][PMo11VIMoVO40]}·5H2O (RuNi-PMo), have been synthesized through a traditional hydrothermal method. They are composed of [Ru(bpy)3]2+-derived hexa-carboxylate Keggin-type anion [PMo11VIMoVO40]4-. In addition, their structures were well characterized by various spectroscopic methods. Under the irradiation visible light (λ > 400 nm), RuZn-PMo RuNi-PMo as heterogeneous photocatalysts showed efficient photocatalytic performance in coupling reaction amines, with TONs 451 454, respectively. Moreover, exhibited excellent reusability stability after three continuous cycles. Besides, EPR measurements performed to elucidate mechanism.

Language: Английский

Citations

0