Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 504, P. 158258 - 158258
Published: Dec. 12, 2024
Language: Английский
Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123212 - 123212
Published: Feb. 24, 2025
Language: Английский
Citations
2
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Oral ulcer wounds are difficult to heal due bacterial infections, persistent inflammatory responses, and excessive reactive oxygen species (ROS). Therefore, the elimination of bacteria, removal ROS, reduction inflammation prerequisites for treatment mouth wounds. In this study, oligomeric proanthocyanidins (OPC) 3-(aminomethyl)phenylboronic acid-modified hyaluronic acid (HP) were used form polymer gels through dynamic covalent borate bonds. Minocycline hydrochloride (MH) was then loaded into gel, a multifunctional MH/OPC-HP microneedles (MNs) with ROS-responsive properties prepared using vacuum method. The MNs can rapidly release MH in diffusive manner sustainably OPC response ROS. gel-based extended retention oral ulcers, leading prolonged ROS scavenging effects. Cytocompatibility hemocompatibility tests showed that had good biocompatibility. Antibacterial experiments demonstrated exhibited excellent antibacterial vitro indicated could effectively clear reduce oxidative stress damage, inhibit M1-type macrophage polarization, induce M2-type polarization. Furthermore, vivo revealed pro-inflammatory cytokines, promote neovascularization, accelerate epithelial healing significantly rat model wound infection. summary, hold promise as therapeutic strategy enhancing
Language: Английский
Citations
1
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Excessive reactive oxygen species, disruption of the epithelial barrier, immune dysregulation, and gut microbiota imbalance are key factors driving onset inflammatory bowel disease (IBD) complicating its treatment. Prompt diagnosis diseases precise delivery therapeutic agents to inflamed intestinal sites offer promising targeted strategies for effectively treating IBD. Here, a barium sulfate-based nanoplatform (BaSO4@PDA@CeO2/DSP, BPCD) synergistic nanozymes drugs was developed. With enhanced colonic retention after oral drug delivery, this enables effective targeting CT imaging guidance address multiple contributing A comprehensive effect achieved through action cerium oxide with optimized Ce3+/Ce4+ ratio sustained release dexamethasone sodium phosphate. Benefiting from superior gastrointestinal stability, is highly in IBD by alleviating oxidative stress, modulating macrophage polarization balance, flora composition, repairing barrier. BPCD inhibits development mechanisms has biocompatibility, emerging as practical alternative traditional therapies.
Language: Английский
Citations
0
Science Advances, Journal Year: 2025, Volume and Issue: 11(18)
Published: May 1, 2025
The regulation of microglial dysfunction has become increasingly prominent in treatment Alzheimer's disease (AD). Herein, we develop a scalable polymer-involved biomimetic assembly that responds to intracerebral reactive oxygen species (ROS) for elastic spreading and concentration-dependent drug therapy. Structurally, polymer thermally sensitive deformation is selected hydrophobic loading curcumin (Cur) coordinative grafting onto ultrasmall ceria (CeO2) by compression at transition temperature, which further sealed self-polymerized dopamine with apolipoprotein decoration improve shuttling. When triggered ROS the lesions, burst exposure Cur polymer-linked CeO2 (PCeO2) achieved. concentrated switches amyloid-β (Aβ)-activated microglia into normal mobilizing phagocytosis, sustainable antioxidant capacity prevent mitochondrial damage after phagocytosis PCeO2-captured Aβ. After administration, our findings reveal microglia-mediated Aβ clearance, neuroprotection, elimination AD mice. Collectively, this provides promising approach treatments.
Language: Английский
Citations
0
Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123269 - 123269
Published: March 1, 2025
Language: Английский
Citations
0
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(16), P. 4065 - 4082
Published: Jan. 1, 2024
In this review, the application of nanomaterials and hydrogels in treatment intracerebral hemorrhage is summarized. addition, potential challenges prospects these biomaterials for clinical translation are discussed.
Language: Английский
Citations
3
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 185, P. 441 - 455
Published: July 11, 2024
Language: Английский
Citations
2
Ceramics International, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
2
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 23, 2024
Abstract Posterior uveitis is a leading cause of vision impairment and blindness globally due to its detrimental effects on the choroid retina. The condition worsened by oxidative stress, which heightens inflammation perpetuates cycle damage that current treatments only temporarily relieve. To address this, novel treatment involving in situ crystallization ultrasmall cerium oxide nanoparticles (≈3 nm) mesenchymal stem cell (MSC) extracellular vesicles (EVs) for management primed mycobacterial (PMU) developed. This nanohybrid leverages individual synergistic components comprehensive therapeutic approach. act as nanozyme reduce scavenge excessive reactive oxygen species (ROS), while MSC EVs, with their biocompatibility, modulate inflammatory infiltration alleviate tissue damage. system offers promising new strategy ocular diseases characterized stress inflammation.
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 25, 2024
Abstract The infected chronic wound area has a unique microenvironment featuring hypoxia, excessive reactive oxygen species (ROS), and inflammatory conditions. Bacteria‐formed biofilms limit the anti‐inflammation efficiency of most therapeutics by hindering their penetration into deep tissues increasing drug resistance. unitary modulation pro‐inflammatory M1 macrophage polarization cannot relieve inflammation immediately. Here, “all in one” folic acid‐modified small organic molecule‐based nanoparticles (2TT‐ m C6B@CeO 2 @FA, PCFs) are developed, which possess dual‐targeting to bacteria macrophages, double photothermal therapy (PTT), enzymatic‐like activities. Based on considerable catalase‐ superoxide dismutase‐like activities, PCFs can efficiently scavenge ROS produce (O ). generated O automatically drive movement as nanomotors further promote rescue hypoxia. scavenging promotes macrophages polarized anti‐inflammatory M2 macrophages. study also identifies that FA‐modified target selectively eliminate through PTT, relieves healing. Transcriptome analysis confirms inhibit expression inflammatory‐related genes while cytokines. In vivo experiments identify benefit neovascularization neonatal tissue generation at sites.
Language: Английский
Citations
1