Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
137(1)
Published: Aug. 22, 2024
Abstract
Single‐atom
nanozymes
(SAzymes)
with
ultrahigh
atom
utilization
efficiency
have
been
extensively
applied
in
reactive
oxygen
species
(ROS)‐mediated
cancer
therapy.
However,
the
high
energy
barriers
of
reaction
intermediates
on
single‐atom
sites
and
overexpressed
antioxidants
tumor
microenvironment
restrict
amplification
oxidative
stress,
resulting
unsatisfactory
therapeutic
efficacy.
Herein,
we
report
a
multi‐enzyme
mimetic
MoCu
dual‐atom
nanozyme
(MoCu
DAzyme)
various
catalytic
active
sites,
which
exhibits
peroxidase,
oxidase,
glutathione
(GSH)
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
oxidase
mimicking
activities.
Compared
Mo
SAzyme,
introduction
Cu
atoms,
formation
synergetic
effects
among
enhance
substrate
adsorption
reduce
barrier,
thereby
endowing
DAzyme
stronger
Benefiting
from
above
enzyme‐like
activities,
can
not
only
generate
multiple
ROS,
but
also
deplete
GSH
block
its
regeneration
to
trigger
cascade
stress.
Additionally,
strong
optical
absorption
near‐infrared
II
bio‐window
endows
remarkable
photothermal
conversion
performance.
Consequently,
achieves
high‐efficiency
synergistic
treatment
incorporating
collaborative
therapy
This
work
will
advance
applications
DAzymes
provide
valuable
insights
for
nanocatalytic
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Abstract
Targeted
delivery
of
glucose
oxidase
(GOx)
using
MXene
remains
a
great
challenge
due
to
its
poor
dispersion
and
susceptibility
oxidation,
the
hypoxia
high
glutathione
(GSH)
contents
make
situation
even
more
worrying.
Herein,
bovine
serum
albumin‐mediated
non‐chemical
modification
strategy
is
developed,
endowing
titanium
carbide
with
long‐time
water‐dispersion
further
integrating
it
as
glycolysis‐controllable
therapy
system
without
any
chemotherapeutic
agents.
The
also
constructs
an
effective
O
2
cycling
GSH
degradation
pathway,
which
fundamentally
adjusts
tumor
microenvironment
greatly
elevates
both
in
vivo
vitro
effects.
Reactive
oxygen
species
are
generated
disrupt
balance
oxidative
stress.
Moreover,
reduced
efficiency
mitochondrial
energy
production
significantly
inhibits
level
glycolysis
hinders
supply.
study
presents
cancer
treatment
combining
starvation/photothermal
therapy,
has
superior
anti‐cancer
effects
dual
reducing
levels
diminishing
cellular
capacity.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 12, 2024
Abstract
Proteins
have
emerged
as
promising
therapeutics
in
oncology
due
to
their
great
specificity.
Many
treatment
strategies
are
developed
based
on
protein
biologics,
such
immunotherapy,
starvation
therapy,
and
pro‐apoptosis
while
some
biologics
entered
the
clinics.
However,
clinical
translation
is
severely
impeded
by
instability,
short
circulation
time,
poor
transmembrane
transportation,
immunogenicity.
Micro‐
nano‐particles‐based
drug
delivery
platforms
designed
solve
those
problems
enhance
therapeutic
efficacy.
This
review
first
summarizes
different
types
of
proteins
research
stages,
highlighting
administration
limitations.
Next,
various
micro‐
nano‐particles
described
demonstrate
how
they
can
overcome
The
potential
then
explored
efficacy
combinational
therapies.
Finally,
challenges
future
directions
carriers
discussed
for
optimized
delivery.
ChemMedChem,
Journal Year:
2024,
Volume and Issue:
19(21)
Published: June 29, 2024
Abstract
Copper,
as
an
essential
trace
nutrient
for
human,
plays
a
crucial
role
in
numerous
cellular
activities,
and
is
vital
maintaining
homeostasis
organisms.
Deviations
from
normal
intracellular
copper
concentration
range
can
disrupt
the
lead
to
cell
death.
Cell
death
process
which
cells
lose
their
vitality
cannot
sustain
metabolism,
has
various
forms.
The
recently
discovered
cuproptosis
mechanism
differs
previously
recognized
forms,
triggered
by
accumulation.
discovery
of
sparked
interest
among
researchers,
this
been
applied
treatment
intractable
diseases,
including
different
types
cancer.
However,
developed
cuproptosis‐based
therapies
have
revealed
certain
limitations,
such
low
immunostimulatory
efficiency,
poor
tumor
targeting,
inhibition
microenvironment.
Therefore,
researchers
are
devoted
combining
with
existing
cancer
develop
more
effective
synergistic
therapies.
This
review
summarizes
latest
research
advancements
cancer,
focus
on
Finally,
it
provides
outlook
future
development
anti‐tumor
therapy.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
The
other
functions
of
bacterial
membrane
vesicles
(BMVs)
except
serving
as
immune
adjuvants
and
vaccine
platforms
are
yet
to
be
further
explored.
This
study
investigates
the
photothermal
properties
Rhodobacter
sphaeroides‐derived
BMVs
(RMVs)
beyond
their
immunostimulatory
properties.
A
multifunctional
nano‐biohybrid,
termed
CuM@RR,
is
constructed
by
encapsulating
Cu‐based
metal–organic
framework
(CuM)
nanoparticles
into
DSPE‐PEG
2000
‐RGD‐functionalized
RMVs,
leveraging
functionalization
cargo
capacity
BMVs.
‐RGD
modification
facilitates
targeted
delivery
CuM@RR
tumor
sites.
CuM
core
within
decomposes
in
acid
microenvironment,
releasing
Cu
2+
inducing
cell
cuproptosis.
Under
808
nm
near‐infrared
irradiation,
effect‐induced
apoptosis
synergizes
with
copper
ions
overload‐induced
cuproptosis,
causing
irreversible
mitochondrial
damage
cells
triggering
strong
immunogenic
death
(ICD).
released
damage‐associated
molecular
patterns
(DAMPs)
tumor‐associated
antigens
(TAAs)
during
ICD,
along
inherent
immunoadjuvant
elicit
robust
anti‐tumor
responses.
In
vivo
experiments
confirm
that
significantly
suppresses
growth
prevents
rechallenge
without
obvious
systemic
toxicity
under
synergistic
effects
therapy,
immunotherapy,
suggesting
great
potential
this
nano‐biohybrid
developing
safe
effective
multi‐therapeutic
strategies.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 27, 2024
Making
the
utmost
of
differences
and
advantages
multiple
disciplines,
interdisciplinary
integration
breaks
science
boundaries
accelerates
progress
in
mutual
quests.
As
an
organic
connection
material
science,
enzymology,
biomedicine,
nanozyme-related
research
is
further
supported
by
computer
technology,
which
injects
new
vitality,
contributes
to
in-depth
understanding,
unprecedented
insights,
broadened
application
possibilities.
Utilizing
computer-aided
first-principles
method,
high-speed
high-throughput
mathematic,
physic,
chemic
models
are
introduced
perform
atomic-level
kinetic
analysis
for
nanocatalytic
reaction
process,
theoretically
illustrate
underlying
nanozymetic
mechanism
structure-function
relationship.
On
this
basis,
nanozymes
with
desirable
properties
can
be
designed
demand-oriented
synthesized
without
repeated
trial-and-error
experiments.
Besides
that,
computational
device
also
play
indispensable
role
nanozyme-based
detecting
methods
realize
automatic
readouts
improved
accuracy
reproducibility.
Here,
work
focuses
on
crossing
nanocatalysis
inspire
nanozyme
field
a
greater
extent.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 14, 2024
The
integration
of
photoacoustic
imaging
(PAI)
and
photothermal
therapy
(PTT)
within
the
second
near-infrared
(NIR-II)
window,
offering
a
combination
high-resolution
precise
non-invasive
thermal
ablation,
presents
an
attractive
opportunity
for
cancer
treatment.
Despite
significant
promise,
development
this
noninvasive
phototheranostic
nanomedicines
encounters
challenges
that
stem
from
tumor
thermotolerance
limited
therapeutic
efficacy.
In
contribution,
we
designed
amphiphilic
semiconducting
polymer
brush
(SPB)
featuring
thermosensitive
carbon
monoxide
(CO)
donor
(TDF-CO)
NIR-II
PAI-assisted
gas-augmented
deep-tissue
PTT.
TDF-CO
nanoparticles
(NPs)
exhibited
powerful
conversion
efficiency
(43.1%)
capacity
to
trigger
CO
release
after
photoirradiation.
Notably,
liberated
not
only
acts
on
mitochondria,
leading
mitochondrial
dysfunction
promoting
cellular
apoptosis
but
also
hinders
overexpression
heat
shock
proteins
(HSPs),
enhancing
tumor's
thermosensitivity
This
dual
action
accelerates
achieving
synergistic
effect
in
Intravenous
administration
NPs
4T1
tumor-bearing
mice
demonstrated
bright
PAI
signals
remarkable
ablation
under
1064
nm
laser
irradiation,
underscoring
potential
CO-mediated
photothermal/gas
therapy.
We
envision
tailor-made
multifunctional
light-triggered
SPB
provides
feasible
approach
amplify
performance
PTT
advancing
future
phototheranostics.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
137(1)
Published: Aug. 22, 2024
Abstract
Single‐atom
nanozymes
(SAzymes)
with
ultrahigh
atom
utilization
efficiency
have
been
extensively
applied
in
reactive
oxygen
species
(ROS)‐mediated
cancer
therapy.
However,
the
high
energy
barriers
of
reaction
intermediates
on
single‐atom
sites
and
overexpressed
antioxidants
tumor
microenvironment
restrict
amplification
oxidative
stress,
resulting
unsatisfactory
therapeutic
efficacy.
Herein,
we
report
a
multi‐enzyme
mimetic
MoCu
dual‐atom
nanozyme
(MoCu
DAzyme)
various
catalytic
active
sites,
which
exhibits
peroxidase,
oxidase,
glutathione
(GSH)
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
oxidase
mimicking
activities.
Compared
Mo
SAzyme,
introduction
Cu
atoms,
formation
synergetic
effects
among
enhance
substrate
adsorption
reduce
barrier,
thereby
endowing
DAzyme
stronger
Benefiting
from
above
enzyme‐like
activities,
can
not
only
generate
multiple
ROS,
but
also
deplete
GSH
block
its
regeneration
to
trigger
cascade
stress.
Additionally,
strong
optical
absorption
near‐infrared
II
bio‐window
endows
remarkable
photothermal
conversion
performance.
Consequently,
achieves
high‐efficiency
synergistic
treatment
incorporating
collaborative
therapy
This
work
will
advance
applications
DAzymes
provide
valuable
insights
for
nanocatalytic
