Catalytic Nanozyme: Unlocking new horizons in articular cartilage degeneration treatment DOI
Ke Ma, Ting Liu, Chunguang Zhou

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 541, P. 216845 - 216845

Published: May 29, 2025

Language: Английский

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives DOI Creative Commons
Yubin Yao, Xi Cui, Shenglong Ding

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Severe bone and cartilage defects caused by trauma are challenging to treat, often resulting in poor outcomes. An endogenous electric field (EnEF) is crucial for regeneration, making electrical materials a promising therapy. This review provides comprehensive overview of the role bioelectric signals cells, alongside recent advancements biomaterials, with particular emphasis on nanogenerators, piezoelectric materials, triboelectric scaffolds, zwitterionic hydrogels. It further investigates impact these biomaterials as well applications both exogenous stimulation (ES) mechanisms underlying ES‐induced cellular molecular responses. Finally, underscores future directions ES systems tissue engineering, emphasizing critical importance integrating structural integrity, mechanical properties, signal delivery into intelligent implantable scaffolds.

Language: Английский

Citations

4
Piezoelectric Hydrogel with Self-Powered Biomechanical Stimulation Enhances Bone Regeneration DOI
John H. Zhang, Lei Huang,

Weisin Chen

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

3
Unleashing the Potential of Electroactive Hybrid Biomaterials and Self-Powered Systems for Bone Therapeutics DOI Creative Commons
Shichang Liu, Farid Manshaii, Jinmiao Chen

et al.

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 17(1)

Published: Oct. 17, 2024

The incidence of large bone defects caused by traumatic injury is increasing worldwide, and the tissue regeneration process requires a long recovery time due to limited self-healing capability. Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in remodeling regeneration. Inspired bioelectricity, electrical stimulation has widely considered an external intervention induce osteogenic lineage cells enhance synthesis extracellular matrix, thereby accelerating With ongoing advances biomaterials energy-harvesting techniques, electroactive self-powered systems biomimetic approaches ensure functional recapitulating natural electrophysiological microenvironment healthy tissue. In this review, we first introduce role bioelectricity endogenous electric field summarize different techniques electrically stimulate Next, highlight latest progress exploring hybrid such triboelectric piezoelectric-based nanogenerators photovoltaic cell-based devices their implementation engineering. Finally, emphasize significance simulating target tissue's propose opportunities challenges faced bioelectronics for repair strategies.

Language: Английский

Citations

15
Ingenious Structure Engineering to Enhance Piezoelectricity in Poly(vinylidene fluoride) for Biomedical Applications DOI
Jiwei Cui,

Lijun Du,

Zhiheng Meng

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(9), P. 5541 - 5591

Published: Aug. 12, 2024

The future development of wearable/implantable sensing and medical devices relies on substrates with excellent flexibility, stability, biocompatibility, self-powered capabilities. Enhancing the energy efficiency convenience is crucial, converting external mechanical into electrical a promising strategy for long-term advancement. Poly(vinylidene fluoride) (PVDF), known its piezoelectricity, an outstanding representative electroactive polymer. Ingeniously designed PVDF-based polymers have been fabricated as piezoelectric various applications. Notably, performance platforms determined by their structural characteristics at different scales. This Review highlights how researchers can strategically engineer structures microscopic, mesoscopic, macroscopic We discuss advanced research diverse designs in biomedical sensing, disease diagnosis, treatment. Ultimately, we try to give perspectives trends biomedicine, providing valuable insights further research.

Language: Английский

Citations

10
3D bioprinted piezoelectric hydrogel synergized with LIPUS to promote bone regeneration DOI Creative Commons
Meng Li,

Xiantong Hu,

Xiaofei Liu

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101604 - 101604

Published: Feb. 22, 2025

Language: Английский

Citations

2
Piezoelectric materials for bone implants: opportunities and challenges DOI

Xionggang Chen,

Shiping Zhang, Shun Peng

et al.

Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 110841 - 110841

Published: March 1, 2025

Language: Английский

Citations

2
A one-step polyphenol-based functionalization strategy of dual-enhanced antibacterial and osteogenic surfaces DOI
Xiao Chen,

Meizhou Sun,

Lujiao Zhang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151792 - 151792

Published: April 29, 2024

Language: Английский

Citations

8
Conductive, injectable, and self-healing collagen-hyaluronic acid hydrogels loaded with bacterial cellulose and gold nanoparticles for heart tissue engineering DOI

Hajar Tohidi,

Nahid Maleki,

Abdolreza Simchi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135749 - 135749

Published: Sept. 1, 2024

Language: Английский

Citations

7
Biomimetic electroactive materials and devices for regenerative engineering DOI
Yang Liu,

Yunyang Bai,

Boon Chin Heng

et al.

Nature Reviews Electrical Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

Citations

1
3D printed shape-memory piezoelectric scaffolds with in-situ self-power properties for bone defect repair DOI Creative Commons
Bing Li,

Yichao Ma,

Kanwal Fatima

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 24, 2025

Electrical stimulation has been shown to regulate early immunity and late-stage osteogenesis in bone repair. However, achieving in-situ electrical the form of self-power vivo during initial postoperative stages when patients have limited mobility remains challenging. In this study, we developed a 3D-printed self-powered composite scaffold composed shape memory polyurethane elastomers (SMPU) polyvinylidene fluoride (PVDF) piezoelectric nanofibers. The demonstrates excellent performance, allowing for minimally invasive implantation. During process, can provide mechanical force PVDF nanofibers generate charge. Therefore, was achieved through integration process effects, it be used period. Additionally, output voltage under continuous stimulation, indicating that apply sustained rehabilitation exercises regain mobility. Both cell experiments animal studies confirmed effectively immune microenvironment enhance osteogenesis. This study successfully achieves by integrating which is expected an effective repair strategy tissue engineering.

Language: Английский

Citations

1