Electroactive membranes enhance in-situ alveolar ridge preservation via spatiotemporal electrical modulation of cell motility DOI
Yanlan Wang, Shiqi Zhou,

Xiaoshuang Wang

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 317, P. 123077 - 123077

Published: Dec. 31, 2024

Language: Английский

Conductive, injectable, and self-healing collagen-hyaluronic acid hydrogels loaded with bacterial cellulose and gold nanoparticles for heart tissue engineering DOI

Hajar Tohidi,

Nahid Maleki,

Abdolreza Simchi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135749 - 135749

Published: Sept. 1, 2024

Language: Английский

Citations

2
The Biomimetic Electrical Stimulation System Inducing Osteogenic Differentiations of BMSCs DOI
Zengzilu Xia, H X Zhang, Qing Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(42), P. 56730 - 56743

Published: Oct. 12, 2024

Electrical stimulation has been used clinically as an adjunct therapy to accelerate the healing of bone defects, and its mechanism requires further investigations. The complexity physiological microenvironment makes it challenging study effect electrical signal on cells alone. Therefore, artificial system mimicking cell in vitro was developed address this issue. In work, a novel constructed based polypyrrole nanowires (ppyNWs) with high aspect ratio. Synthesized ppyNWs formed conductive network composited hydrogel which contained modified gelatin methacrylate, providing culture matrix for marrow mesenchymal stem cells. dual-network had improved mechanical, electrical, hydrophilic properties. It able imitate three-dimensional structure allowed adjustable stimulations following system. This integrated plates, platinum electrodes, copper wires, external power sources construct optimum voltage determined be 2 V, exhibited remarkable biocompatibility. Moreover, significant promotion spreading, osteogenic makers, bone-related gene expression RNA-seq analysis revealed that osteogenesis correlated Notch, BMP/Smad, calcium pathways. proven biomimetic could regulate procedure, provided information about how regulates differentiations.

Language: Английский

Citations

2
Ultrasound-Triggered Piezoelectric Polyetheretherketone with Boosted Osteogenesis via Regulating Akt/GSK3β/β-Catenin Pathway DOI Creative Commons
Yue Li, Yingying Fan, Siyu Zhao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

Abstract Maxillofacial bone defects can severely impact quality of life by impairing physiological functions such as chewing, breathing, swallowing, and pronunciation. Polyether ether ketone (PEEK) is commonly used for the repair maxillofacial due to its mechanical adaptability, while osteogenic properties still need refinement. Herein, we have utilized piezoelectric effect exhibited barium titanate (BTO) under low-intensity pulsed ultrasound (LIPUS) develop an responsive PEEK (PDA@BTO-SPEEK, PBSP) through mediating polydopamine (PDA), repairing defects. After modification PDA@BTO, PBSP possesses better hydrophilicity, which conducive cell growth adhesion. Simultaneously, virtue characteristics BTO, obtains a coefficient that matches cortex. Notably, when stimulated LIPUS, it generate stable electricity effectively accelerate differentiation osteoblasts regulation Piezo1-induced calcium (Ca2+) influx Akt/GSK3β/β-catenin pathway. In addition, presents satisfactory therapeutic effects in rat skull defect models, efficiency be further improved LIPUS stimulation with high tissue penetration. Collectively, + exhibits great potential promising alternative strategy

Language: Английский

Citations

0
Electroactive membranes enhance in-situ alveolar ridge preservation via spatiotemporal electrical modulation of cell motility DOI
Yanlan Wang, Shiqi Zhou,

Xiaoshuang Wang

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 317, P. 123077 - 123077

Published: Dec. 31, 2024

Language: Английский

Citations

0