Nano Today, Journal Year: 2024, Volume and Issue: 59, P. 102551 - 102551
Published: Nov. 11, 2024
Language: Английский
Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122895 - 122895
Published: Oct. 19, 2024
Language: Английский
Citations
4
Fundamental Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139566 - 139566
Published: Jan. 8, 2025
Language: Английский
Citations
0
Research, Journal Year: 2025, Volume and Issue: 8
Published: Jan. 1, 2025
Nanozymes are a class of nanomaterials that exhibit catalytic functions analogous to those natural enzymes. They demonstrate considerable promise in the biomedical field, particularly treatment bone infections, due their distinctive physicochemical properties and adjustable activities. Bone infections (e.g., periprosthetic osteomyelitis) challenging treat clinically. Traditional treatments often encounter issues related drug resistance suboptimal anti-infection outcomes. The advent nanozymes has brought with it new avenue hope for infections.
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
Inflammation is a natural immune response triggered by harmful external or internal stimuli. However, when inflammation fails to resolve and restore basal homeostasis, it can lead various inflammatory diseases such as rheumatoid arthritis (RA), bowel disease (IBD), diabetic chronic wound (DCW). The modulation of follows highly complex mechanism, monotherapy often insufficient for treating conditions. Therefore, developing next-generation nanocarriers anti-inflammatory drug delivery multi-target combination therapies critical. Metal-organic frameworks (MOFs), class porous coordination polymers with large surface areas adaptable porosity, have emerged promising systems (DDS) due their biodegradability, high loading capacity, stimuli-responsive release, ease functionalization. Over the past five years, MOFs shown significant promise in diseases, either DDS intrinsic anti-oxidative agents. Additionally, hybrid MOFs, which combine nanozymes, offer multifunctional platform great potential. This review intends provide comprehensive recent development MOF-based nanomedicines therapy diseases. challenges future directions research into use treatment these will also be discussed.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Host immune rejection has long been recognized as a major contributor to the poor survival rates of exogenous stem cells (ESCs). In this study, we present simple and versatile strategy protect ESCs from host system insults by developing protective "armor." This armor was designed using tannic acid (TA), leveraging its strong affinity for biomacromolecules anti-inflammatory properties. Prior implantation, can be readily applied surface individual ESCs, cell aggregates, sheets, or cell-laden hydrogel systems simply immersing them in TA solution several seconds, without additional processing steps. The TA-based effectively modulates acute inflammatory response during initial days postimplantation scavenging reactive oxygen species (ROS), thereby creating an ESCs-friendly microenvironment. evidenced reduction infiltration pro-inflammatory secretion cytokines. Consequently, engrafted significantly enhanced, with preserved stemness immunomodulatory functions. regenerative potential further demonstrated rat periodontal defect model. These findings provide novel approach enhancing performance offer straightforward shield rejection.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Abstract Thromboangiitis obliterans (TAO) is a chronic peripheral vascular condition characterized by thrombotic and inflammatory acceleration. As promising therapeutic modality for the TAO, mesenchymal stem cells (MSCs) transplantation expected to circumvent traditional drug therapy surgical interventions. Nonetheless, MSCs hindered owing poor survival, retention, engraftment of transplanted cells. The objective this research develop MSCs‐ cerium oxide nanoparticles (CeNPs)‐laden injectable methacrylated gelatin (GelMA)‐based hydrogel microspheres using microfluidics discern their potential regulate oxidative stress inflammation in rat model TAO. CeNPs‐loaded photocroslinkable GelMA not only protected against but also facilitated endothelial functional recovery, revascularization ischemic limb, suppression factors from macrophages. further conferred mechanical support prolonged residence time enhance efficacy cell therapy. In vivo study confirmed that combination CeNPs microsphere exhibited positive synergistic effect on tissue recovery angiogenesis. Taken together, work presents novel approach based integration nano‐micron combined microspheres, which may have implications TAO
Language: Английский
Citations
0
Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12
Published: Sept. 23, 2024
Bacterial infections are a growing problem, and antibiotic drugs can be widely used to fight bacterial infections. However, the overuse of antibiotics evolution bacteria have led emergence drug-resistant bacteria, severely reducing effectiveness treatment. Therefore, it is very important develop new effective antibacterial strategies multi-drug resistant bacteria. Nanozyme kind enzyme-like catalytic nanomaterials with unique physical chemical properties, high stability, structural diversity, adjustable activity, low cost, easy storage so on. In addition, nanozymes also excellent broad-spectrum properties good biocompatibility, showing broad application prospects in field antibacterial. this paper, we reviewed research progress nanozymes. At first, mechanism was summarized, then introduced. Finally, challenges were discussed, development prospect clarified.
Language: Английский
Citations
2
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(2)
Published: Nov. 19, 2024
Abstract Magnetic resonance imaging (MRI) is a noninvasive and radiation‐free technique used for soft tissue. However, there are some limitations of the MRI modality, such as low sensitivity poor image resolution. Artificially engineered magnetic nanoprobes have been extensively explored versatile platform ultrasensitive contrast agents due to their unique physiochemical characteristics tunable properties. In this review, emphasis on recent progress in with different structures elements, including gadolinium‐, iron‐, manganese‐based metal‐free nanoprobes. The key influencing factors advanced engineering strategies modulating relaxation ratio systematically condensed. Furthermore, widespread visualization applications real time monitoring major organs accurate disease diagnosing, cerebrovascular, ischemia, Alzheimer's disease, liver fibrosis, whole‐body tumors, inflammation, well multi‐mode summarized. Finally, challenges prospects future development discussed, promising specifically emphasized improving biocompatibility, precisely optimal size, AI‐driven prediction design, multifunctional self‐assembly enhance diagnostics. This review will provide new inspiration artificial nanotechnology‐based molecular probes medical diagnosis therapy MRI.
Language: Английский
Citations
1