Cell Membrane-Coated Biomimetic Nanoparticles in Cancer Treatment

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 531 - 531

Published: April 12, 2024

Nanoparticle-based drug delivery systems hold promise for cancer treatment by enhancing the solubility and stability of anti-tumor drugs. Nonetheless, challenges inadequate targeting limited biocompatibility persist. In recent years, cell membrane nano-biomimetic have emerged as a focal point research development, due to their exceptional traits, including precise targeting, low toxicity, good biocompatibility. This review outlines categorization advantages bionic nano-delivery systems, provides an introduction preparation methods, assesses applications in treatment, chemotherapy, gene therapy, immunotherapy, photodynamic photothermal combination therapy. Notably, delves into application various identifies opportunities future advancement. Embracing membrane-coated biomimetic nanoparticles presents novel unparalleled avenue personalized tumor

Language: Английский

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Research progress of copper-based metal–organic frameworks for cancer diagnosis and therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215943 - 215943

Published: May 14, 2024

Language: Английский

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PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 3, 2025

An emerging strategy in cancer therapy involves inducing reactive oxygen species (ROS), specifically within tumors using nanozymes. However, existing nanozymes suffer from limitations such as low reactivity, poor biocompatibility, and limited targeting capabilities, hindering their therapeutic efficacy. In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities effective separation of charges, which can catalyze hydrogen peroxide (H2O2) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation. Through facilitating electron transfer enhancing active sites, enhanced peroxidase-like (POD-like) enzymatic activity glutathione (GSH) depletion abilities are boosted through a simple co-reduction process, leading promising anti-tumor activity. The between Pd Ru contributes POD-like Then, by oxidizing endogenous overexpressed GSH, cycling prevents GSH consuming ROS. Furthermore, surface plasmon resonance effect on ensures its photothermal performance local heating, further promoting integrated multi-modal approach has demonstrated significant anti-cancer effects vivo studies. exhibit high catalytic efficiency excellent offering valuable insights for development nano-catalysts/enzymes biomedical applications.

Language: Английский

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Advances in Nanodynamic Therapy for Cancer Treatment

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(7), P. 648 - 648

Published: April 8, 2024

Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances tumor-specific targeting and selectivity leveraging the microenvironment (TME) mechanisms that boost immune responses. It also minimizes damage surrounding healthy tissues cytotoxicity cells, showing promise cancer treatment, with significant potential. This review covers research progress five major nanodynamic therapies: photodynamic (PDT), electrodynamic (EDT), sonodynamic (SDT), radiodynamic (RDT), chemodynamic (CDT), emphasizing role advanced nanotechnology development for purposes. The mechanisms, effects, challenges faced these NDTs are discussed, along their respective solutions enhancing efficacy, such as pH response, delivery, combined immunotherapy. Finally, this briefly addresses clinical translation NDT.

Language: Английский

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Recent Advances of Versatile Fluorophores for Multifunctional Biomedical Imaging in the NIR-II Region

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Fluorescence imaging in the second near-infrared region (NIR-II, 1000-1700 nm) enables high-resolution visualization of deep-tissue biological architecture and physiopathological events, due to reduced light absorption, scattering tissue autofluorescence. Numerous versatile NIR-II fluorescent probes have been reported over past decades. In this review, we first provide a detailed account advantages fluorescence region. Following this, classification, design performance optimization strategies are systematically discussed, along with broad range biomedical applications

Language: Английский

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Rational Design of NIR‐II Fluorescence/Photoacoustic Nanosensor Tailored for Mechanisms of Diabetes‐Related Breast Cancer

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Breast cancer (BC) is the second most common cause of induced death worldwide. Current statistics has disclosed that diabetic BC patients have significantly worse survival rate compared with nondiabetic patients. However, specific mechanism still being explored. Herein, a novel NIR-II nanosensor DNPS for nitric oxide (NO) fluorescence/photoacoustic (FL/PA) imaging capability developed to explore by which diabetes promoting breast progression. In model, exhibits great advantages low intrinsic background, high sensitivity, and deep tissue penetration successfully confirmed expression level NO higher than indicating causes elevated levels in tumor microenvironment. RNA-seq analysis results show hyperglycemia caused leads weakened immune response initiates transcription translation inducible synthase (iNOS) gene produce NO. Besides, increased carcinogens related Nitric 2 (Nos2), such as Spp1, Mmp11, Kitl, develop more rapidly. Here, probe applied first study diabetes-related certain reference value provided subsequent research on progression cancer.

Language: Английский

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Harnessing stimuli-responsive NO nanomaterials for advanced multi-disease therapy

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216540 - 216540

Published: Feb. 27, 2025

Language: Английский

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Engineered Photoactivatable Nanomicelles for Ferroptosis-like Combinational Tumor Therapy In Vitro and In Vivo

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Nitric oxide (NO)-based gas therapy has attracted increasing attention as a promising approach for tumor treatment, but elevated levels of glutathione (GSH) in the microenvironment significantly limit their therapeutic effectiveness. In this study, type engineered photoactivatable nanomicelles Ce6/NI@PEP@HA (CNPH) were developed combinational photodynamic and NO therapy. CNPH was capable targeted accumulation to tumors, where it depleted GSH released effectively produce reactive oxygen species (ROS) with oxidative damage under laser irradiation at 660 nm. The consumption induced deactivation peroxidase activity, leading enhanced toxic lipid peroxide enabled ferroptosis-like outcome. Additionally, effective production ROS resulted mitochondrial dysfunction, characterized by disruption membrane potential decreased adenosine triphosphate concentration. vivo animal experiments indicated that achieved inhibition 89.1%, proven be more strategy contrast any single modality. consequence, opened up new horizon cutting-edge noninvasive paradigm advanced treatments.

Language: Английский

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Near-Infrared Light-Controlled Nitric Oxide Delivery Combined with In Situ Activated Chemotherapy for Enhanced Multimodal Therapy

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Development of nanoplatforms with in situ activation for chemotherapy represents a promising modality biomedical application. Herein, multifunctional nanoplatform, CMS@DTC@PDA@RuNO@FA (abbreviated as CDPNF NPs), was developed highly efficient antitumor therapy, which diethyldithiocarbamate (DTC)-loaded mesoporous Cu2MoS4 (CMS) nanoparticles were covered by polydopamine (PDA) layers and further covalently modified NO donor (RuNO) folic acid (FA)-directing moiety. Under the mild acidic tumor microenvironment (TME), NPs co-liberated DTC Cu2+ site, where formation cytotoxic Cu(DTC)2 complex effectively killed cells. Furthermore, under near-infrared (NIR) light irradiation, could deliver nitric oxide (NO) produce superoxide anions (O2•-), followed more toxic peroxynitrite (ONOO-), led to promoted cell apoptosis. 1064 nm NIR vivo experiments demonstrated an impressively high inhibition rate (∼97%) while good biocompatibility. This work activated approach precision medicine that might imply its potential clinical applications.

Language: Английский

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A robust Metal–Organic Framework-Based nanozyme with Multienzyme-Like properties for synergistic tumor therapy via efficient and sustainable Nitric oxide generation

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 693, P. 137603 - 137603

Published: April 15, 2025

Language: Английский

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