Non-small
cell
lung
cancer
(NSCLC)
is
the
most
prevalent
type
of
cancer,
characterized
by
a
relatively
slow
growth
rate
and
propensity
toward
distant
metastases
following
local
spread.
These
factors
present
significant
challenges
in
both
diagnosis
treatment
NSCLC,
particularly
for
early
stage
NSCLC.
In
this
study,
based
on
self-assembled
functionalized
tetrahedral
DNA
nanostructure
(TDN),
multifunctional
drug
delivery
system
has
been
constructed
NSCLC
adenocarcinoma
line
A549
(A549
cells)
to
achieve
intracellular
imaging
combined
delivery.
The
TDN
was
vitro
four
vertices
were
with
Cy5,
s6
aptamer,
p28
cell-penetrating
peptide
siRNA,
respectively.
Subsequently,
daunorubicin
(DAU)
loaded
obtain
DAU@TDN-p28-s6-siRNA
through
intercalation
double-stranded
DNA.
While
Cy5
employed
tracking
imaging,
aptamer
used
target
cells
enrich
around
cells,
can
facilitate
entrance
into
via
endocytosis.
Once
taken
inside
cell,
modified
siRNA
bind
mRNA
guiding
translation
ERBB3
protein
down-regulate
its
expression,
ultimately
leading
inhibition
growth.
Simultaneously,
targeted
delivery,
DAU
accurately
inhibits
tumor
activity,
thus
achieving
synergy
inhibit
cells.
experiments
have
demonstrated
that
compared
control,
reduces
expression
71.27%,
viability
37.84%,
as
well
exhibits
high
targeting
specificity.
Therefore,
development
assemblies
provides
an
efficient
way
potential
biomedical
field.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 13, 2024
Retinal
neovascular
disease
is
a
leading
cause
of
vision
loss
and
blindness
globally.
It
occurs
when
abnormal
new
blood
vessels
form
in
the
retina.
In
this
study,
we
utilized
tetrahedral
framework
nucleic
acids
(tFNAs)
as
vehicles
to
load
quercetin
(QUE),
small-molecule
flavonoid,
forming
deoxyribonucleic
acid
(DNA)
nanocomplex,
tFNAs-QUE.
Our
data
show
nanocomplex
inhibits
pathological
neovascularization,
reduces
area
retinal
nonperfusion
area,
protects
neurons,
preserves
visual
function.
Further,
discovered
that
tFNAs-QUE
selectively
upregulates
AKT/Nrf2/HO-1
signaling
pathway,
which
can
suppress
vascular
growth
exert
antioxidative
effects.
Therefore,
study
presents
promising
small-molecule-loading
mechanism
for
treatment
ischemic
diseases.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(39), P. 26704 - 26721
Published: Sept. 14, 2024
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
chronic
and
irreversible
lung
disease,
developing
an
effective
treatment
remains
challenge.
The
limited
therapeutic
options
are
primarily
delivered
by
the
oral
route,
among
which
pirfenidone
(PFD)
improves
dysfunction
patient
quality
of
life.
However,
its
high
dose
severe
side
effects
(dyspepsia
systemic
photosensitivity)
limit
clinical
value.
Intratracheal
aerosolization
excellent
alternative
method
for
treating
diseases
because
it
increases
concentration
drug
needed
to
reach
focal
site.
Tetrahedral
framework
nucleic
acid
(tFNA)
delivery
system
with
exceptional
capabilities.
Therefore,
we
synthesized
PFD-tFNA
(Pt)
complex
using
tFNA
as
vehicle
achieved
quantitative
nebulized
lungs
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Tetrahedral
framework
nucleic
acids
(tFNAs)
are
renowned
for
their
controllable
self-assembly,
exceptional
programmability,
and
excellent
biocompatibility,
which
have
led
to
widespread
application
in
the
biomedical
field.
Beyond
these
features,
tFNAs
demonstrate
unique
chemical
biological
properties
including
high
cellular
uptake
efficiency,
structural
bio-stability,
tissue
permeability,
derived
from
distinctive
3D
structure.
To
date,
an
extensive
range
of
tFNA-based
nanostructures
intelligently
designed
developed
various
applications
such
as
drug
delivery,
gene
therapy,
biosensing,
engineering,
among
other
emerging
fields.
In
addition
role
delivery
systems,
also
possess
intrinsic
that
render
them
highly
effective
therapeutic
agents
treatment
complex
diseases,
arthritis,
neurodegenerative
disorders,
cardiovascular
diseases.
This
dual
functionality
significantly
enhances
utility
research,
presenting
valuable
opportunities
development
next-generation
medical
technologies
across
diverse
diagnostic
platforms.
Consequently,
this
review
comprehensively
introduces
latest
advancements
field,
with
a
focus
on
benefits
nanoplatforms,
inherent
capabilities
agents.
Furthermore,
current
limitations,
challenges,
future
perspectives
explored.
Non-small
cell
lung
cancer
(NSCLC)
is
the
most
prevalent
type
of
cancer,
characterized
by
a
relatively
slow
growth
rate
and
propensity
toward
distant
metastases
following
local
spread.
These
factors
present
significant
challenges
in
both
diagnosis
treatment
NSCLC,
particularly
for
early
stage
NSCLC.
In
this
study,
based
on
self-assembled
functionalized
tetrahedral
DNA
nanostructure
(TDN),
multifunctional
drug
delivery
system
has
been
constructed
NSCLC
adenocarcinoma
line
A549
(A549
cells)
to
achieve
intracellular
imaging
combined
delivery.
The
TDN
was
vitro
four
vertices
were
with
Cy5,
s6
aptamer,
p28
cell-penetrating
peptide
siRNA,
respectively.
Subsequently,
daunorubicin
(DAU)
loaded
obtain
DAU@TDN-p28-s6-siRNA
through
intercalation
double-stranded
DNA.
While
Cy5
employed
tracking
imaging,
aptamer
used
target
cells
enrich
around
cells,
can
facilitate
entrance
into
via
endocytosis.
Once
taken
inside
cell,
modified
siRNA
bind
mRNA
guiding
translation
ERBB3
protein
down-regulate
its
expression,
ultimately
leading
inhibition
growth.
Simultaneously,
targeted
delivery,
DAU
accurately
inhibits
tumor
activity,
thus
achieving
synergy
inhibit
cells.
experiments
have
demonstrated
that
compared
control,
reduces
expression
71.27%,
viability
37.84%,
as
well
exhibits
high
targeting
specificity.
Therefore,
development
assemblies
provides
an
efficient
way
potential
biomedical
field.
