3D‐Printed Tissue‐Specific Nanospike‐Based Adhesive Materials for Time‐Regulated Synergistic Tumor Therapy and Tissue Regeneration In Vivo

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(48)

Published: June 26, 2024

Abstract The growing concerns regarding cancer recurrence, unpredictable bone deficiencies, and postoperative bacterial infections subsequent to the surgical removal of tumors have highlighted need for multifaceted scaffolds that afford tumor therapy, effective vascularized reconstruction. However, challenging trilemma has emerged in realm balance between achieving appropriate mechanical strength, ensuring biocompatibility, optimizing a degradation rate aligns with bone‐regenerative rate. Considering these challenges, innovative theragenerative platform is developed by utilizing 3D printing‐based nanospikes first time. This comprises tissue‐specific nanospiked hydroxyapatite decorated magnesium (nMg) adhesive DNA (aDNA). incorporation nMg within polylactic acid (PLA) matrix confers photothermal capabilities helps modulate properties improve biocompatibility platform. Simultaneously, immobilized aDNA contributed enhancement healing. These 3D‐printed tissue‐adhesive platforms exhibit superior offer controlled degradability. Moreover, they enable eradication bacteria osteosarcoma through hyperthermia promote angiogenesis osteogenesis, both vitro vivo. groundbreaking approach poised pave way fabrication design novel implantable biomaterials integrate therapeutic regenerative functions.

Language: Английский

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Bioactive hydrogel formulations for regeneration of pathological bone defects

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 686 - 714

Published: Feb. 17, 2025

Language: Английский

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Developing functional hydrogels for treatment of oral diseases

Smart Medicine, Journal Year: 2024, Volume and Issue: 3(3)

Published: July 25, 2024

Oral disease is a severe healthcare challenge that diminishes people's quality of life. Functional hydrogels with suitable biodegradability, biocompatibility, and tunable mechanical properties have attracted remarkable interest been developed for treating oral diseases. In this review, we present up-to-date research on the management dental caries, endodontics, periapical periodontitis, depending progression The strategies mucosal diseases salivary gland are then classified. After that, focus application related to tumor therapy tissue defects. Finally, review prospects restrictions perspectives utilization in treatment. We believe will promote advancement more amicable, functional personalized approaches

Language: Английский

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Progress in injectable hydrogels for hard tissue regeneration in the last decade

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 39

Published: Jan. 24, 2025

Bone disorders have increased with increasing the human lifespan, and despite tissue's ability to self-regeneration, in many congenital problems hard fractures, bone grafting such as autograft, allograft, biomaterials implantation through surgery is traditionally used. Because of adverse effects these methods, emergence injectable hydrogels without need for causing more pain patient stunning develop a new pattern tissue engineering. These materials are formed various natural synthetic polymers crosslinked network chemical methods click chemistry, Michael enhancement, Schiff's base enzymatic reaction physical interactions high water absorption which can mimic environment cells. The purpose this research review capabilities class regeneration last decade adaptable properties, fill defect sites an irregular shape, grow hormones or release drugs, response external stimuli.

Language: Английский

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3D‐Printed Biomimetic Ceramic Scaffolds with Photothermal/Chemodynamic Effects and Ionic Microenvironment for Preventing Tumor Recurrence and Promoting Vascularized Bone Reconstruction

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Osteosarcoma is an aggressive malignant bone tumor predominantly affecting adolescents and young adults, characterized by a high mortality rate. A significant challenge in treatment the presence of residual cells associated defects. Here, novel functionalized biomimetic ceramic scaffold presented, which combines photothermal chemodynamic therapies to effectively target tumors while promoting vascularized regeneration through optimized ionic microenvironment. The consists 3D‐printed zinc‐doped β‐tricalcium phosphate matrix dopamine‐modified hyaluronic acid hydrogel membrane loaded with Ti 3 C 2 MXene iron ions. In microenvironment, degrades rapidly, releasing ions that lead glutathione depletion downregulation peroxidase 4. When exposed near‐infrared light, enhances local temperature catalyzes redox cycling ions, leading generation hydroxyl radicals Fenton reactions. This process results lipid peroxidation induces ferroptosis cells. Following clearance cells, gradual release zinc encourages osteogenic differentiation vascularization, facilitating regeneration. Therefore, exhibits effective anti‐osteosarcoma properties supports repair, presenting promising option for osteosarcoma‐associated

Language: Английский

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Mussel-inspired Integrated functional 3D printed scaffolds with molybdenum disulfide nanoflowers for tumor therapy and bone reconstruction

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161399 - 161399

Published: March 1, 2025

Language: Английский

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Fe₃O₄@PDA Nanoparticle‐Doped Smart Hydrogel Scaffold for Osteochondral Defect Repair by Synergistical Stimulation

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Osteochondral defects are common orthopedic conditions that can lead to osteoarthritis and severe joint pain. Recently, smart biohydrogels have been widely applied in osteochondral repair regeneration, owing their 3D structural resemblance tissues remarkable responsiveness external stimuli. Glucosamine hydrochloride (GH) has proved stimulate the proliferation chondrogenic differentiation of bone mesenchymal stem cells (BMSC), thereby accelerating wound healing tissue regeneration. Herein, double‐crosslinked hydrogels SPA 5 ‐Mg/GH/FP fabricated using sodium alginate, acrylamide N‐Isopropylacrylamide (NIPAM) as substrates. Simultaneously, incorporation Mg 2+ Polydopamine (PDA)‐coated Fe 3 O 4 NPs into system further enhanced its properties. The results emphasized favorable microenvironment created by architecture hydrogel, which effectively facilitated regeneration defects. Notably, controlled release GH aligned with process is achieved through @PDA near‐infrared light. Moreover, vivo assessments demonstrated effectiveness hydrogel repairing defects, highlighting similarities native tissue. This promising outcome underscores potential a sophisticated solution for addressing challenges associated repair.

Language: Английский

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Injectable Bismuth‐Based Composite Enable Bone Defect Repair for Osteosarcoma Treatment and Mild Magnetothermal Bone Regeneration

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Bone implant materials are essential for treating bone defects in clinical, however, current options face challenges minimally invasive implantation, precise situ molding, and long surgical times with large incisions. To address these drawbacks, the newly‐emerging low‐melting‐point bismuth‐based alloys as injectable implants, combined clinically applied polymethyl methacrylate (PMMA) cement proposed here to innovatively design multifunctional bismuth‐PMMA composites (BPCs) effective repair. The as‐prepared BPCs offer excellent injectability, enhanced mechanical properties (≈252% increase compressive strength), favorable magnetothermal effects, enabling invasive, molding via easygoing injection orthopedic surgeries. introduction of PMMA significantly improves strength while maintaining injectability bismuth alloys, reduces exothermic heat during curing prevent thermal damage tissue. In vivo experiments demonstrate that under an alternating magnetic field, exhibit outstanding tumor cell killing capability inhibit osteosarcoma growth through efficient hyperthermia. Further, long‐term implantation results coupled histological analysis display stable filling evident regeneration, attributed collaborative efficacy BPC mild therapy. This study promises revolutionize repair provide a versatile strategy 3D‐printed orthopedics future.

Language: Английский

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Injectable Hydrogel Technologies for Bone Disease Treatment

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Injectable hydrogels represent a highly promising approach for localized drug delivery systems (DDSs) in the management of bone-related conditions such as osteoporosis, osteonecrosis, osteoarthritis, osteomyelitis, and osteosarcoma. Their appeal lies their biocompatibility, adjustable mechanical properties, capacity to respond external stimuli, including pH, temperature, light, redox potential, ionic strength, enzymatic activity. These features enable enhanced targeted bioactive agents. This mini-review evaluates synthesis injectable well recent advancements treating range bone disorders, focusing on mechanisms sustained DDSs delivering drugs, nanoparticles, growth factors, cells (e.g., stem cells). Moreover, it highlights clinical studies disease treatment. Additionally, emphasizes potential synergy between hydrogel-based point-of-care technologies, which are anticipated play pivotal role future therapies. have transform treatment by facilitating precise, sustained, minimally invasive therapeutic delivery. Nevertheless, significant challenges, long-term scalability, reproducibility, precise regulation release kinetics, must be addressed unlock fully. Addressing these challenges will not only advance therapy but also open new avenues regenerative medicine personalized healthcare.

Language: Английский

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Hydrogel Containing Bismuth Molybdate Nanosheets with Piezoelectricity and Nanoenzyme Activity for Promoting Osteoblast Responses

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

The development of piezoelectric biomaterials with the capability to produce electrical signals and scavenge reactive oxygen species (ROS) is a novel strategy for stimulating osteoblast responses promoting bone regeneration. Herein, tungsten (W), iridium (Ir), ruthenium (Ru) codoped bismuth molybdate (4(W/Ru/Ir)-BMO) nanosheets improved piezoelectricity enzyme-like (CAT-like SOD-like) activities were constructed by using hydrothermal method. A composite hydrogel oxidized sodium alginate/gelatin (OSA/GEL) 4(W/Ru/Ir)-BMO (OSA/GEL/4-B) was also prepared. Due presence 4(W/Ru/Ir)-BMO, OSA/GEL/4-B exhibited not only but activities. Under ultrasound (US), generated that significantly promoted proliferation osteogenic differentiation marrow stromal cells. Furthermore, effect CAT-like (production oxygen) SOD-like (scavenger ROS) attributed codoping W, Ir, Ru ions, which resulted in lattice distortion enhanced crystal asymmetry, produced regulating microenvironment. Moreover, improvement field triggered US accelerated electron transfer alleviating cellular oxidative stress provided an antioxidant microenvironment responses. This may provide pathway

Language: Английский

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