Near‐Infrared Multiple‐Resonance Polycyclic Aromatic Hydrocarbon as Type I Photosensitizer Toward High‐Performance Synergistic Phototherapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract Type I photosensitization is of particular significance in the anaerobic tumor treatment. Nonetheless, development high‐performance type photosensitizers (PSs) remains challenging, due to weak absorption and inefficient intersystem crossing (ISC) progress. Herein, an effective approach toward a near‐infrared (NIR) PS ( NIR‐BN ) demonstrated using boron/nitrogen‐embedded polycyclic aromatic hydrocarbon with multiple‐resonance (MR) character, for first time. A small singlet‐triplet splitting (Δ E ST = 0.09 eV) high molar extinction coefficient (3.3 × 10 4 M −1 cm NIR MR‐configured supports efficient ISC triplet sensitization. The distorted molecular configurations induce multi‐model structural relaxations after optical excitation, resulting remarkable photothermal conversion efficiency exceeding 50% nanoparticles. Of note, nanoparticles are capable generating highly toxic superoxide anion radical (O 2 •− under 660 nm laser irradiation, benefiting from vigorous intramolecular dihedral angle vibrations excited states. Consequently, biocompatible demonstrates superior performance vivo synergistic photodynamic therapies.

Language: Английский

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Synergistic Integration of Aggregation-Induced Emission and FRET Mechanisms in Conjugated Polymers via Molecular Engineering for Ultrasensitive, Rapid, and Discriminative Detection of Perfluoroalkyl Substances

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

The global contamination of water bodies by persistent organic pollutants (perfluoroalkyl substances (PFAS)) has generated significant societal concern, emphasizing the urgent need for smart strategies their rapid, ultratrace, and on-site detection. Conjugated polymers (CPs) are exceptional fluorescence sensing materials with signal-amplification properties, yet performance is often hindered a conventional aggregation-caused quenching (ACQ) effect. Herein, we present two acceptor-engineered aggregation-induced emission (AIE)-active CPs (FTD-MI FTD-C8-MI) integrated efficient Förster resonance energy transfer (FRET) mechanisms ultralow detection PFAS. FTD-MI exhibits turn-off (cyan to dark) response, while FTD-C8-MI shows ratiometric red) response PFAS due synergistic effect AIE interchain FRET, facilitated electrostatic hydrophobic interactions upon binding. Both demonstrate excellent sensitivity at subnanomolar level toward most abundant PFAS, perfluorooctanoic acid (PFOA), perfluorooctanesulfonic (PFOS). mechanism been thoroughly investigated both experimental simulation studies. Additionally, an optical sensor array coupled machine learning algorithms established discriminative six types Finally, portable smartphone platform custom-designed "app" was developed real-time, on-site, semiquantitative analysis in actual samples. Thus, providing sensitive, portable, cost-effective, user-friendly solution, this work offers powerful tool monitoring pollution, ensuring safety, reducing risks public health.

Language: Английский

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C9-Aryl-substituted berberine derivatives with tunable AIE properties for cell imaging application

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(23), P. 4739 - 4747

Published: Jan. 1, 2024

C9-position-aryl-substituted berberine derivatives with tunable aggregation-induced emission properties were obtained by tuning intramolecular charge transfer.

Language: Английский

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Near-Infrared-II Photoactivated Iron(III) Complexes for Highly Efficient RNS and ROS Synergistic Therapy

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Reactive nitrogen species (RNS) are more lethal than reactive oxygen (ROS), which gives them a very promising future in the field of cancer treatment. However, there still few drugs available for RNS generation. In this work, two 5th-order nonlinear optical materials, FB-Fe(III)/SNP@PEG and FB-Fe(II)-FB/SNP@PEG, synthesized. The outstanding properties help to achieve generation bounteous superoxide anions (O

Language: Английский

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Diradicaloid-Loaded Polypeptide Nanoparticles for Two-Photon NIR Phototheranostics

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(44), P. 59907 - 59920

Published: Oct. 23, 2024

Stable organic radicals, with unique electronic transitions from the ground state (D0) to doublet excited (D1), show promise as high-fluorescence quantum yield dyes. While small-molecule photosensitizers (PSs) have advanced for tumor photodynamic therapy (PDT), opportunities exist enhance their performance and functionality. Herein, we synthesized Thiele's fluorocarbon derivative diradicaloid TFC-I nearly 100% PLQY integrated it into amphiphilic polypeptide nanoparticles, P-TI, using a precursor-doping approach. P-TI demonstrated notable features including high photostability, aggregation-induced emission, bright near-infrared fluorescence, substantial (37% PLQY), robust two-photon absorption (∼400 GM cross section), superior ROS generation compared commercial PSs. In vitro in vivo experiments confirmed that performed well mitochondria-targeted PDT, fluorescence imaging, biosafety. This work highlights use of stable radicals efficient PDT deep tissue imaging.

Language: Английский

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Activatable Two-Photon-Excited Molecular Fluorescent Probes for Near-Infrared Biosensing and Bioimaging

ACS Applied Engineering Materials, Journal Year: 2024, Volume and Issue: 2(11), P. 2504 - 2520

Published: Nov. 9, 2024

Two-photon-excited fluorescence imaging (TPEFI) is a rapidly advancing technique for detecting analytes and visualizing biological conditions in real time. Compared to conventional one-photon excitation, TPEFI offers advantages, such as deeper tissue penetration, reduced photodamage, high sensitivity, superior temporal resolution, making it highly suitable vivo applications. The integration of biostimuli-responsive elements into two-photon fluorophores has enabled the development bioactivatable two-photon-excited small molecules that are effective near-infrared bioimaging monitoring diverse processes diseases. This review highlights recent progress (2019–2024) design application fluorescent probes specifically developed activity-based bioimaging. We provide succinct overview both chemically enzymatically activated by discussing their structural principles, bioresponsive characteristics, absorption emission properties, use vitro specific biomedical

Language: Английский

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Molecular engineering to design high-performance AIEgens: optical properties, LED devices and water detection

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140779 - 140779

Published: Nov. 1, 2024

Language: Английский

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