Published: Jan. 1, 2024
Language: Английский
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101615 - 101615
Published: Feb. 25, 2025
Language: Английский
Citations
2
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Medical catheters are susceptible to biological contamination and pathogen invasion, leading infection inflammatory complications. The development of antimicrobial coatings for medical devices has emerged as a promising strategy. However, limited functionality the incompatibility between bactericidal properties biosafety remain great challenges. Herein, multifunctional polymer coating (CPB-Ac) is created, incorporating an ultrasonic-responsive carbon monoxide release unit (CORM-Ac) antifouling treat catheter-related As-synthesized CPB-Ac can be stably anchored various with arbitrary shapes compositions via facile UV treatment. Both in vivo vitro experiments demonstrated that this multi-functional exhibits anti-fouling, anti-inflammatory, broad-spectrum antibacterial activities well good biosafety. During initial implantation phase, units effectively inhibit attachment contaminants, significantly reducing risk thrombosis bacterial infection. Once occurs, ultrasonic irradiation activate CO much higher amount 55.3 µm than non-ultrasound controls, therefore rapidly eliminating bacteria alleviating response. It believed work may provide effective method next-generation intelligent against
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
Abstract Medical implants, important consumables, significantly promote patients’ healthcare, but still face challenges of foreign body responses and bacterial infection. Hydrogels can be ideal alternative materials, however, a few them meet the requirements. Herein, TAFe@PVA photothermal hydrogel integrating with negative swelling, long‐term stability, antibacterial, anti‐adhesion, tissue mechanical matching is developed to solve these issues. The crosslinked by H‐bonds microcrystal domains which both enhanced cations or anions based on Hofmeister effect, showing unique swelling self‐enhancement performances in physiological fluid. Attributing self‐polymerization tannic acid (TA) polyvinyl alcohol (PVA) molecular networks, TAFe complexes strongly locked PVA reaching stability. also exhibits great biocompatibility, anti‐oxidation, anti‐bacterial performances, comparing traditional implant material. Since better match skin tissues, fewer macrophages myofibroblasts are activated, depresses unexpected responses. Finally, as effectively abdominal adhesions after operation defects healing. This study introduces promising implant, potentially extends hydrogels wider medical applications.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
Strong attachment in complicated human body environments is of great importance for precision medicine especially with the rapid growth minimal invasive surgery and flexible electronics. Natural organisms highly evolved feet or claws can easily climb complex from dry to wet even underwater, providing significant inspiration strong research. This review summarizes behaviors natural creatures varied such as gecko, tree frog, octopus. Their surfaces' micronano structures material properties exhibit evolutionary adaptations that enable them transition across dry, wet, underwater environments, highlighting intricate mechanism interfacial dynamic behaviors. The liquid/air media regulation contact stress adjustment coupling effects surface materials have been concluded key factors attachments. With bioinspired design, manufacturing methods including mold-assisted replication, nano 3D printing, self-assembly field induced molding discussed. Finally, applications surfaces low damage surgical instruments, tissue repair electronics demonstrated.
Language: Английский
Citations
0
Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101811 - 101811
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Membrane Science, Journal Year: 2024, Volume and Issue: unknown, P. 123597 - 123597
Published: Dec. 1, 2024
Language: Английский
Citations
3
Nano Letters, Journal Year: 2025, Volume and Issue: unknown
Published: March 15, 2025
Postcharging antibacterials have shown good application prospects in combating bacterial infections through electrical interaction. Herein, manganese oxide nanosheets situ grown on carbon fibers (CM) are designed to perform the integration of mechanical intervention and postcharging therapy for efficient killing. This electrode disrupts membranes via sharp-edged microstructures. After charging at a low voltage an ultrashort time, charged CM affects extracellular electron transfer (EET) bacteria during discharge process kill bacteria. Due dual-antibacterial mode, after −1 V (vs saturated calomel electrode, SCE) only 50.4 ± 3 s, lethality rates against Escherichia coli Staphylococcus aureus within 0.5 h both exceed 98%. Our developed ultrafast negatively exhibits high antibacterial activity cytotoxicity fibroblast cells, providing non-antibiotic approach combat infection.
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 21, 2024
Abstract Efficient management of difficult‐to‐heal diabetic wounds remains a clinical challenge owing to bacterial infections, as well oxidative and hyperglycemic complex pathology. Therefore, developing intelligent strategies for wound healing is urgently needed. Herein, an ultrasound (US)‐responsive microneedle (MN) patch ( MN@GOX@TiO 2‐X @CO ) capable controlled delivery carbon monoxide (CO) gas within the skin effective treatment infected developed. Benefiting from specific form patch, sonosensitizer (TiO ), •OH‐responsive CO prodrug (MPA‐CO), glucose oxidase (GOX) can be loaded together effectively delivered infectious wounds. With semi‐fluidic hyaluronic acid (HA) coating under physiological condition, could released efficiently in situ directly acted on tissue upon US triggering. Both vitro vivo results showed that US‐triggered release not only inhibited S. aureus MRSA infection but also promoted fibroblasts proliferation migration physiology, thereby accelerating healing. Collectively, approach addresses impaired regeneration function offers promising therapeutic strategy efficient
Language: Английский
Citations
1
Authorea (Authorea), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 11, 2024
Postoperative adhesions (PAs) are a common complication after intraperitoneal surgery. Hydrogels physical barrier that prevents peritoneal adhesions, but their efficacy is still controversial. In this study, Laponites, layered two-dimensional nanoscale, incorporated into zwitterionic hydrogel (pSBLA) to enhanced biocompatibility and bioactivity develop nanocomposite for rapid prevention of postoperative recurrent adhesion. The anisotropic distribution charges in laponites results strong electrostatic repulsion aqueous solutions enables interactions between amphiphilic ions, thereby enhancing the mechanical properties hydrogels. pSBLA hydrogels also possess series characters an ideal anti-adhesion material, including resistance adhesion against fibrinogen, proteins, bacteria as well cells. mechanism underlying extraordinary hydration elucidated study using molecular dynamic simulations. addition, shown represent major advancement by completely reliably preventing adhesiolysis rat models. Furthermore, mechanistic explorations revealed inhibits inflammatory responses resists fibrosis regulating transforming growth factor-β/Smad signal pathway. Above have therefore provided facile effective strategy improve
Language: Английский
Citations
0