Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Abstract
Regulation
of
bone
microenvironment
(BME)
including
innate
pH
values
and
metal
ions
affects
cellular
functions
activities
osteoblasts
osteoclasts,
thereby
significantly
influencing
the
process
regeneration.
How
to
achieve
multiple
effective
regulations
BME
through
cascade
effects
via
facile
material
design
fabrication
facilitate
osteogenesis
remains
a
challenge.
Herein,
facilely‐designed
resorbable
guided
regeneration
membrane
(PCL/DEX@Ca‐Zol)
based
on
drug‐loaded
metal‐organic
framework
is
reported.
Thereinto,
calcium
ions,
zoledronic
acid,
dexamethasone
embedded
in
can
be
responsively
released
specifically
inside
defect
an
acid‐triggered
manner
synergistically
regulate
by
neutralization
value,
enhancement
osteogenic
differentiation
mineralization,
inhibition
osteoclasts
one‐go.
Along
with
polycaprolactone
as
structural
support
for
fully
utilized
components
composite
material,
enhances
minimized
side
accordingly
achieved
assistance
modulation
effects.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1019 - 1019
Published: Jan. 25, 2025
Atherosclerosis
is
a
complex
inflammatory
process
associated
with
high-mortality
cardiovascular
diseases.
Today,
there
growing
body
of
evidence
linking
atherosclerosis
to
mutations
mitochondrial
DNA
(mtDNA).
But
the
mechanism
this
link
insufficiently
studied.
progression
involves
different
cell
types
and
macrophages
are
one
most
important.
Due
their
high
plasticity,
can
demonstrate
pro-inflammatory
pro-atherogenic
(macrophage
type
M1)
or
anti-inflammatory
anti-atherogenic
M2)
effects.
These
two
types,
formed
as
result
external
stimuli,
differ
significantly
in
metabolic
profile,
which
suggests
central
role
mitochondria
implementation
macrophage
polarization
route.
According
this,
we
assume
that
mtDNA
causing
disturbances
play
an
internal
trigger,
leading
formation
M1
M2.
This
review
provides
comparative
analysis
characteristics
function
possible
associations
linked
inflammation-based
pathologies
including
atherosclerosis.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(44)
Published: Aug. 5, 2024
Implant-associated
infections
(IAIs)
are
the
main
cause
of
prosthetic
implant
failure.
Bacterial
biofilms
prevent
antibiotic
penetration,
and
unique
metabolic
conditions
in
hypoxic
biofilm
microenvironment
may
limit
efficacy
conventional
treatment.
Escaping
survival
bacteria
not
be
continually
eradicated,
resulting
recurrence
IAIs.
Herein,
a
sonosensitive
metal-organic
framework
Cu-TCPP
(tetrakis(4-carboxyphenyl)
porphyrin)
nanosheets
tinidazole
doped
probiotic-derived
membrane
vesicles
(OMVs)
with
high-penetration
sonodynamic
therapy
(SDT),
bacterial
state
interference,
cuproptosis-like
death
to
eradicate
IAIs
is
proposed.
The
can
convert
O
ACS Applied Materials & Interfaces,
Journal Year:
2025,
Volume and Issue:
17(6), P. 8886 - 8900
Published: Jan. 31, 2025
The
controllable
regulation
of
immune
and
osteogenic
processes
plays
a
critical
role
in
the
modification
biocompatible
materials
for
tissue
regeneration.
In
this
study,
titanium
dioxide-europium
coatings
(MAO/Eu)
were
prepared
on
surface
alloy
(Ti-6Al-4V)
via
one-step
process
combining
microarc
oxidation
(MAO)
situ
doping.
incorporation
Eu
significantly
improved
hydrophilic
mechanical
properties
TiO2
without
altering
their
morphology.
presence
effectively
stimulated
calcium
influx
macrophages
activated
β-catenin
through
wnt/β-catenin
signaling
pathway.
Consequently,
macrophage
M2
polarization
was
accelerated
overexpression
prostaglandin
E2
(PGE2).
Additionally,
Ca2+
promoted
differentiation
MC3T3-E1
cells
synergistic
upregulation
transcription
factors
(e.g.,
AP-1,
BMP-2).
vivo
studies
demonstrated
that
MAO/Eu
enhanced
osseointegration
compared
with
group.
Therefore,
shows
promising
potential
as
an
ideal
coating
implants
offers
effective
immunomodulatory
strategies
improves
bone
integration.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(31)
Published: May 20, 2024
Revascularization
after
rotator
cuff
repair
is
crucial
for
tendon-to-bone
healing.
The
chirality
of
materials
has
been
reported
to
influence
their
performance
in
tissue
repair.
However,
data
on
the
use
chiral
structures
optimize
biomaterials
as
a
revascularization
strategy
remain
scarce.
Here,
calcium
silicate
hydrate
(CSO)
films
with
hierarchical
atomic
micrometer
scale
are
developed.
Interestingly,
levorotatory
CSO
(L-CSO)
promote
migration
and
angiogenesis
endothelial
cells,
whereas
dextral
racemic
do
not
induce
same
effects.
Molecular
analysis
demonstrates
that
L-chirality
can
be
recognized
by
integrin
receptors
leads
formation
focal
adhesion,
which
activates
mechanosensitive
ion
channel
transient
receptor
potential
vanilloid
4
conduct
Ca
Biofabrication,
Journal Year:
2025,
Volume and Issue:
17(2), P. 025028 - 025028
Published: March 5, 2025
Ultraviolet
photopolymerization
additive
manufacturing
has
been
used
to
fabricate
calcium
phosphate
(Ca-P)
ceramic
scaffolds
for
repairing
bone
defects,
but
it
is
still
a
challenge
3D
printed
Ca-P
simultaneously
enhance
the
mechanical
strength
and
osteoinductivity.
Here,
we
successfully
developed
high-performance
hydroxyapatite
(HA)
scaffold
containingin-situcarbon
graphene
oxide
(GO)
by
precisely
regulating
degreasing
sintering
atmosphere.
The
results
indicated
that
properties
of
HA
could
be
significantly
improved
amount
ofin-situcarbon.
containing
0.27
wt.%
carbon
achieved
maximum
compressive
12.5
MPa
with
porosity
approximately
70%.
RNA
transcriptome
sequencing
analysis
revealed
thatin-situcarbon
promote
osteogenic
differentiation
improving
oxygen
transport
promoting
expression
multiple
angiogenic
factors.
More
importantly,
in
absence
osteoinductive
agents,
thein-situcarbon
GO
synergistically
promoted
more
effective
mineralization,
demonstrating
enhanced
osteoinductivityin
vitro.In
rodent
model,
bioceramic
also
exhibited
osteogenesis
critical
defects.
Therefore,in-situcarbon
osteoinductivity
scaffolds,
effectively
achieving
substantial
endogenous
regeneration.
This
strategy
will
provide
simple
energy-efficient
approach
engineering
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
Bone
tumors
with
high
mortality
and
disability
have
become
a
major
clinical
challenge.
Herewith,
it
is
necessary
to
design
materials
for
bone
tumor
therapy
repair.
In
this
work,
Fe-doped
polypyrrole
(Fe-Ppy)
CaO2
are
constructed
on
sulfonated
polyetheretherketone
(SP)
form
multistage-responsive
coating.
The
coating
achieves
long-lasting
antitumor
through
chemodynamic
(CDT),
photothermal
(PTT),
combined
immunotherapy.
Fe-Ppy
acts
as
an
electron
pump
replenish
Fe2+
oxidizing
-NH-
-N+-,
which
lasts
the
Fenton
reaction
persistently
produces
reactive
oxygen
species
(ROS)
in
microenvironment
(TME).
selectively
provides
exogenous
H2O2
response
TME
boost
cycle.
Stronger
near-infrared
light
absorption
due
Fe
doping
more
photon
traps
caused
by
porous
structure-induced
scattering
refraction
diminishment
improve
conversion
of
modified
SP.
Furthermore,
ROS
effective
enhance
M1
activation
secrete
TNF-α
IFN
kill
cells.
After
therapy,
Fe-Ppy@CaO2-modified
SP
could
adaptively
switch
macrophage
M2
promote
osteogenesis
abolishment
NIR
stimulation.
summary,
ROS,
enhanced
conversion,
immunomodulation
potential
candidate
tissue
