Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Abstract
Regulation
of
bone
microenvironment
(BME)
including
innate
pH
values
and
metal
ions
affects
cellular
functions
activities
osteoblasts
osteoclasts,
thereby
significantly
influencing
the
process
regeneration.
How
to
achieve
multiple
effective
regulations
BME
through
cascade
effects
via
facile
material
design
fabrication
facilitate
osteogenesis
remains
a
challenge.
Herein,
facilely‐designed
resorbable
guided
regeneration
membrane
(PCL/DEX@Ca‐Zol)
based
on
drug‐loaded
metal‐organic
framework
is
reported.
Thereinto,
calcium
ions,
zoledronic
acid,
dexamethasone
embedded
in
can
be
responsively
released
specifically
inside
defect
an
acid‐triggered
manner
synergistically
regulate
by
neutralization
value,
enhancement
osteogenic
differentiation
mineralization,
inhibition
osteoclasts
one‐go.
Along
with
polycaprolactone
as
structural
support
for
fully
utilized
components
composite
material,
enhances
minimized
side
accordingly
achieved
assistance
modulation
effects.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: May 13, 2025
The
failure
to
repair
bone
defects
in
a
timely
manner
has
detrimental
effect
on
patients’
quality
of
life
and
functional
status.
Consequently,
there
are
increasing
demands
for
medical
interventions
promote
healing
defects.
However,
the
local
inflammation
induced
by
implants
side
effects
associated
with
systemic
use
drugs
have
prompted
research
into
development
bioactive
materials.
Recent
reports
indicated
that
oral
administration
Lactobacillus
acidophilus
(LA)
can
act
as
an
immunomodulator.
In
this
study,
we
strategically
designed
bioceramic
scaffolds
modified
inactivated
LA
biofilms
(LA@BC)
through
UV
irradiation
localized
application
LA.
biosafety
scaffold
was
validated
at
cellular
animal
levels
ensure
it
be
safely
used
without
bacteraemia.
LA@BC
achieved
M1
M2
polarization
macrophages
vitro
reducing
secretion
inflammatory
factors.
addition,
enhanced
osteogenic
marrow
mesenchymal
stem
cells
modulating
Wnt/β-catenin
signaling
pathway.
Furthermore,
osteogenesis
angiogenesis
complement
each
other.
exerted
positive
angiogenic
endothelial
cells.
rat
cranial
defect
model,
upregulated
expression
RUNX2,
OCN,
CD31,
IL-10
tissues,
again
demonstrating
potent
immunomodulatory
effects.
conclusion,
provides
new
strategy
clinical
repair.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Abstract
Regulation
of
bone
microenvironment
(BME)
including
innate
pH
values
and
metal
ions
affects
cellular
functions
activities
osteoblasts
osteoclasts,
thereby
significantly
influencing
the
process
regeneration.
How
to
achieve
multiple
effective
regulations
BME
through
cascade
effects
via
facile
material
design
fabrication
facilitate
osteogenesis
remains
a
challenge.
Herein,
facilely‐designed
resorbable
guided
regeneration
membrane
(PCL/DEX@Ca‐Zol)
based
on
drug‐loaded
metal‐organic
framework
is
reported.
Thereinto,
calcium
ions,
zoledronic
acid,
dexamethasone
embedded
in
can
be
responsively
released
specifically
inside
defect
an
acid‐triggered
manner
synergistically
regulate
by
neutralization
value,
enhancement
osteogenic
differentiation
mineralization,
inhibition
osteoclasts
one‐go.
Along
with
polycaprolactone
as
structural
support
for
fully
utilized
components
composite
material,
enhances
minimized
side
accordingly
achieved
assistance
modulation
effects.
