Hydrogen Bonds and In situ Photoinduced Metallic Bi0/Ni0 Accelerating Z‐Scheme Charge Transfer of BiOBr@NiFe‐LDH for Highly Efficient Photocatalysis DOI

Rongjun Sun,

Zijian Zhu,

Na Tian

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(41)

Published: July 8, 2024

Abstract For heterojunction system, the lack of stable interfacial driving force and definite charge transfer channel makes separation efficiency unsatisfactory. The photoreaction mechanism occurring at interface also receives less attention. Herein, a 2D/2D Z‐scheme junction BiOBr@NiFe‐LDH with large‐area contact featured by short hydrogen bonds strong electric field (IEF) is synthesized, in situ photoinduced metallic species assisting demonstrated. between O atoms from BiOBr H NiFe‐LDH induce significant redistribution, establishing robust IEF. Notably, during photocatalytic reaction, Bi 0 Ni are performed heterojunction, which separately act as electron transport mediator trap to further accelerate up 71.2 %. Theoretical calculations demonstrate that existence strengthens Therefore, high‐speed spatial realized /BiOBr@Ni /NiFe‐LDH, leading prominent activity tetracycline removal ratio 88.3 % within 7 min under visible‐light irradiation presence persulfate, far exceeding majority photocatalysts reported previously. This study provides valid insights for designing bonding systems, advances mechanistic understanding on interfaces.

Language: Английский

Hydrogen Bonds and In situ Photoinduced Metallic Bi0/Ni0 Accelerating Z‐Scheme Charge Transfer of BiOBr@NiFe‐LDH for Highly Efficient Photocatalysis DOI

Rongjun Sun,

Zijian Zhu, Na Tian

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(41)

Published: July 8, 2024

For heterojunction system, the lack of stable interfacial driving force and definite charge transfer channel makes separation efficiency unsatisfactory. The photoreaction mechanism occurring at interface also receives less attention. Herein, a 2D/2D Z-scheme junction BiOBr@NiFe-LDH with large-area contact featured by short hydrogen bonds strong electric field (IEF) is synthesized, in situ photoinduced metallic species assisting demonstrated. between O atoms from BiOBr H NiFe-LDH induce significant redistribution, establishing robust IEF. Notably, during photocatalytic reaction, Bi

Language: Английский

Citations

18
Fuh@Decm Hydrogel Delays Intervertebral Disc Degeneration Through Macrophage Reprogramming and Antioxidant Properties DOI

Jing Sun,

Linjie Chen, Zhenyu Guo

et al.

Published: Jan. 1, 2025

1.Abstract Key pathological factors contributing to intervertebral disc degeneration (IVDD) include excessive production of reactive oxygen species (ROS), depletion the extracellular matrix (ECM), and an imbalance in M1/M2 macrophage ratio. To address these challenges, we developed a novel bioactive hydrogel (FUH@dECM) by integrating high-concentration fucoidan (FU) with decellularized (dECM). This is designed for situ injection, where it undergoes gelation at site administration, replenishing lost ECM nucleus pulposus cells while gradually releasing FU. In vitro, experiments demonstrated that controlled release FU effectively scavenges ROS, promotes polarization towards M2 phenotype, restores metabolic balance. RNA sequencing analysis revealed antioxidant effects FUH@dECM are primarily mediated through activation FOXO signaling pathway, inhibition NF-κB pathway mitigates inflammatory response. vivo rat model IVDD, this system strong mechanistic alignment physiological processes disc, significantly improving IVDD outcomes maintaining height preserving structural integrity tissue. These results underscore potential as promising therapeutic strategy treatment IVDD.

Language: Английский

Citations

0
Engineered Cell Membrane‐Coated Keratin Nanoparticles Attenuated Intervertebral Disc Degeneration by Remodeling the Disc Microenvironment DOI Open Access

Hongyuan Xing,

Run Li, Zizhan Huang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Characterized by a cascade of profound changes in nucleus pulposus (NP) cells, extracellular matrix (ECM), and biomechanics, intervertebral disc degeneration is common multifactorial condition that may lead to various degenerative lumbar disorders. Therapeutic strategies targeting single factor have shown limited efficacy treating degeneration, approaches address multiple pathological ingredients are barely reported. In this study, engineered cell membrane‐encapsulated keratin nanoparticles developed simultaneously alleviate NP senescence promote ECM remodeling. To achieve this, salivary acid glycoengineered adipose mesenchymal stem membranes used coat keratin, core protein for structural support cellular protection. The synthesized membrane‐coated (MKNs) effectively protected mitochondrial integrity cells from oxidative stress‐induced damage. Moreover, MKNs modulate metabolism attenuate senescence. addition, activate integrins at the membrane enhance interactions between ECM, resulting increased anabolism decreased catabolism. proposed multi‐targeted strategy block cycle inside efficacious potential clinical application.

Language: Английский

Citations

0
Research progress on intervertebral disc repair strategies and mechanisms based on hydrogel DOI

Zekun Hua,

Yuyue Zhao, Meng Zhang

et al.

Journal of Biomaterials Applications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Intervertebral disc degeneration (IDD) arises from a complex interplay of genetic, environmental, and age-related factors, culminating in spectrum low back pain (LBP) disorders that exert significant societal economic impact. The present therapeutic landscape for IDD poses formidable clinical hurdles, necessitating the exploration innovative treatment modalities. hydrogel, as biomaterial, exhibits superior biocompatibility compared to other biomaterials such bioceramics bio-metal materials. It also demonstrates mechanical properties closer those natural intervertebral discs (IVDs) favorable biodegradability conducive IVD regeneration. Therefore, it has emerged promising candidate material field regenerative medicine tissue engineering treating IDD. Hydrogels have made strides treatment. Particularly, injectable hydrogels not only provide support but enable controlled release bioactive molecules, playing crucial role mitigating inflammation promoting extracellular matrix (ECM) Furthermore, ability achieve minimally invasive implantation helps minimize damage. This article initially provides concise exposition structure function IVD, progression IDD, delineates extant interventions Subsequently, categorizes hydrogels, encapsulates recent advancements cellular therapies, delves into mechanisms through which foster Ultimately, deliberates on prospects challenges attendant hydrogel therapy

Language: Английский

Citations

0
MXene‐Based Photothermal‐Responsive Injectable Hydrogel Microsphere Modulates Physicochemical Microenvironment to Alleviate Osteoarthritis DOI Creative Commons

Zehua Gong,

Linjie Chen, Xiaolei Zhou

et al.

Smart Medicine, Journal Year: 2025, Volume and Issue: 4(2)

Published: April 13, 2025

ABSTRACT Osteoarthritis (OA) is a physical lubrication microenvironment‐inadequate disease accompanied by sustained chronic chemical inflammation microenvironment and the progression of articular cartilage destruction. Despite promising OA treatment outcomes observed in enhancement inspired ball bearings to reduce friction support loads, therapeutic effect near‐infrared (NIR) irradiation‐based photothermal‐responsive controlled release “smart hydrogel microspheres” on remains unclear. Here, we prepared MXene/NIPIAM‐based injectable microspheres encapsulating diclofenac sodium using microfluidic system. Consequently, NIR demonstrate beneficial effects modulating microenvironment, laying foundation for application smart microsphere delivery systems loaded with bioactive factors (including agents, cells, factors) regulate multiple pathological microenvironments regenerative medicine.

Language: Английский

Citations

0
H2O2 Self‐Supplied MoS2/CaO2 Nanozyme Hydrogel with Near‐Infrared Photothermal Synergetic Cascade Peroxidase‐Like Activity for Wound Disinfection DOI
Jinyi Huang, Ihsan Ullah, Linjie Chen

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 6, 2024

Abstract In wound healing and clinical anti‐infection therapy, the current feasibility of nanocatalysts is extremely limited because inadequate reactive oxygen species (ROS) generation. Herein, a novel H 2 O self‐supplying nanocomposite (M/C/AEK) consists molybdenum disulfide (MoS ) decorated with calcium peroxide (CaO prepared at ambient temperature encapsulated in AEK hydrogel. presence poly(vinyl pyrrolidone) (PVP), CaO nanoclusters, ≈30 nm, are anchored on MoS surface. /CaO can induce both cascaded peroxidase (POD)‐like catalase (CAT)‐like catalytic activity to produce toxic hydroxyl radicals through self‐supplied responsive faintly acidic environment acute wounds. The POD‐like increased under compared neutral conditions, allowing selective treatment acute, slightly wounds while avoiding side effects high‐concentration antibacterial agents normal tissues. high near‐infrared photothermal effect synergistically POD‐like/CAT‐like boosts production more ROS eradicate Staphylococcus aureus Escherichia coli bacteria (98.6% 98.9%) effectively selectively stimulate healing. porous M/C/AEK hydrogel microenvironment efficiently capture bacteria, its Ca 2+ ions keratin healing, revealing excellent potential advanced care infection control therapies.

Language: Английский

Citations

3
Nanotechnology-Enhanced Pharmacotherapy for Intervertebral Disc Degeneration Treatment DOI Creative Commons
Shaoyan Shi, Xuehai Ou, Chao Liu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 14043 - 14058

Published: Dec. 1, 2024

Intervertebral disc degeneration (IDD) is a primary contributor to chronic back pain and disability globally, with current therapeutic approaches often proving inadequate due the complex nature of its pathophysiology. This review assesses potential nanoparticle-driven pharmacotherapies address intricate challenges presented by IDD. We initially analyze mechanisms driving IDD, particular emphasis on mitochondrial dysfunction, oxidative stress, inflammatory microenvironment, all which play pivotal roles in degeneration. Then, we evaluate application metal-phenolic catalytic nanodots targeting defects alleviating stress within degenerative environment. Additionally, multifunctional stimuli-responsive nanoparticles are explored for their capacity provide precise controlled release, offering improved localization sustained delivery. Finally, outline future research directions identify emerging trends nanoparticle-based therapies, highlighting significantly advance IDD treatment overcoming limitations conventional modalities enabling more effective, targeted management strategies.

Language: Английский

Citations

2
Hydrogen Bonds and In situ Photoinduced Metallic Bi0/Ni0 Accelerating Z‐Scheme Charge Transfer of BiOBr@NiFe‐LDH for Highly Efficient Photocatalysis DOI

Rongjun Sun,

Zijian Zhu,

Na Tian

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(41)

Published: July 8, 2024

Abstract For heterojunction system, the lack of stable interfacial driving force and definite charge transfer channel makes separation efficiency unsatisfactory. The photoreaction mechanism occurring at interface also receives less attention. Herein, a 2D/2D Z‐scheme junction BiOBr@NiFe‐LDH with large‐area contact featured by short hydrogen bonds strong electric field (IEF) is synthesized, in situ photoinduced metallic species assisting demonstrated. between O atoms from BiOBr H NiFe‐LDH induce significant redistribution, establishing robust IEF. Notably, during photocatalytic reaction, Bi 0 Ni are performed heterojunction, which separately act as electron transport mediator trap to further accelerate up 71.2 %. Theoretical calculations demonstrate that existence strengthens Therefore, high‐speed spatial realized /BiOBr@Ni /NiFe‐LDH, leading prominent activity tetracycline removal ratio 88.3 % within 7 min under visible‐light irradiation presence persulfate, far exceeding majority photocatalysts reported previously. This study provides valid insights for designing bonding systems, advances mechanistic understanding on interfaces.

Language: Английский

Citations

1