Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy DOI

Zhi-Hang He,

Hanxiao Tang,

Yanna Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The oxygen consumption during chemodynamic therapy (CDT) can lead to severe cellular hypoxia, resulting in an increase the hypoxia inducible factor-1α (HIF-1α) level, which hinders effectiveness of CDT and induces tumor metastasis. Here, we propose a strategy synergistic between HIF-1α inhibitor avoid limitations reduce risk Herein, based on coordination Fe3+ apigenin (API, inhibitor), constructed hyaluronic acid (HA)-modified API-Fe nanoparticles (AF@HA NPs) for synergetic chemotherapy glutathione (GSH)-activated self-enhancing CDT. AF@HA NPs have high drug loading capacity, stability, biocompatibility. Furthermore, overexpressed GSH cancer cells Fe2+, weakened API Fe, promoted release chemotherapy. Fe2+ could react with endogenous H2O2 generate hydroxyl groups In addition, released inhibit expression sensitivity reactive species (ROS), thereby achieving effect results vitro vivo experiments indicated that effectively growth suppress lung metastasis cells.

Language: Английский

Hollow Heterojunction Nanocages of Zif-8@Zns@Cus for Synergistic Tumor Therapy DOI
Yuqin Chen,

Benjian Sun,

Zhouyu Yu

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Amino-tuned S-scheme ZIF nano-heterojunction coating up/downconversion nanoparticles for near-infrared-triggered catalytic therapy and bioimaging DOI
Chunsheng Li,

Jiawei Qu,

Yunlong Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160576 - 160576

Published: Feb. 1, 2025

Language: Английский

Citations

0
Radio‐Activated Selenium‐Doped Janus Ag/Ag2SexSy Nanoparticles for Precise Cancer NIR‐II Fluorescence Imaging and Radiosensitization Therapy DOI Creative Commons

Kang Zhu,

Zhanyuan Li,

Jingjing Cao

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract The efficacy of radiotherapy (RT) is often limited by insufficient tumor selectivity and suboptimal therapeutic responses. To overcome these problems, a new kind selenium‐doped Ag/Ag 2 S Janus nanoparticles (Ag/Ag Se x y JNPs) presented as radio‐responsive molecular probes for precise imaging enhanced radiosensitization. By adjusting the selenium precursor input, heterojunction with tunable doping ratios are synthesized, optimizing X‐ray absorption energy storage properties. Upon irradiation, JNPs interact overexpressed hydrogen peroxide (H O ) in cells, generating highly toxic hydroxyl radicals (·OH), which effectively induce cell apoptosis. Additionally, Selenium incorporation improves electron–hole pair separation efficiency enhances photocurrent response, promoting increased electron transfer ·OH generation, thus amplifying reactive oxygen species (ROS) production enhancing Furthermore, fluorescence “OFF‐ON” mechanism, triggered H ‐induced etching silver allows real‐time monitoring levels via second near‐infrared window (NIR‐II) (FL) “Turn On”, delineates boundaries RT reduce side effects to normal tissue. This dual‐functional platform not only enables tracking but also outcomes, offering promising approach precision cancer treatment.

Language: Английский

Citations

0
Debut of enzyme-responsive anionic cyanine for overlap-free NIR-II-to-I dual-channel tumour imaging DOI Creative Commons

Feiyi Chu,

Bin Feng,

Yiyang Zhou

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: 16(10), P. 4490 - 4500

Published: Jan. 1, 2025

Bridging the disparity between traditional surgical resection imaging and ex vivo histopathology, fluorescence is considered a promising tool in disease diagnosis navigation. Nevertheless, its usefulness undermined by variability of single-wavelength signals limited penetration NIR-I (650-900 nm) bioimaging. In this work, we present novel NIR-II ratiometric fluorescent probe (CFC-GSH) with γ-glutamyl transpeptidase (GGT) sensitivity for multifunctional This leverages GSH-capped anionic cyanine, advantages high brightness, excellent photostability, specificity favourable biocompatibility. CFC-GSH exhibits an intrinsically stable signal prior to triggering, which can be utilized systemic circulation vessel outlining microvascular imaging. At tumour site GGT over expression, intramolecular S,N-rearrangement would initiate conversion sulphur-substituted cyanine amino-substituted resulting significant emission shift 270 nm. Using dual-channel changes, effectively differentiates subcutaneous hepatocellular carcinoma (HCC) normal tissue precisely localizes metastatic HCC tumours abdominal cavity. These results reveal that potential as multiprospective candidate screening diagnostic various biological scenarios.

Language: Английский

Citations

0
Nanomedicine with simple structure for programmable heat-shock protein inhibition and sensitized synergistic therapy DOI Creative Commons
Hanji Huang, Yan Sun, Jinhong Cai

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161307 - 161307

Published: March 1, 2025

Language: Английский

Citations

0
Hollow heterojunction nanocages of zeolitic imidazolate framework-8@zinc sulfide@copper sulfide for synergistic tumor therapy DOI
Yuqin Chen,

Benjian Sun,

Zhouyu Yu

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 695, P. 137811 - 137811

Published: May 6, 2025

Language: Английский

Citations

0
Janus Nanoprobe with Dual-Modal NIR-II Fluorescence/Photoacoustic Imaging for Precision Cancer Radiosensitizing Therapy DOI
Shiyu Wang,

Wenzheng Liu,

Yixi Cao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 10, 2025

The use of radiotherapy sensitizers has proven to be effective in overcoming tumor resistance and improving treatment efficacy. However, challenges such as poor biocompatibility difficulty accurately guiding with high efficiency still persist. Herein, we propose a radiosensitizer Janus nanostructure address these issues by enabling dual-modal fluorescence (FL)/photoacoustic (PA) imaging the second near-infrared region (NIR-II, 900-1700 nm) for precise efficient guidance. nanoprobes are fabricated initially coating silica (SiO2) on one end gold nanorod (AuNR) aspect ratio, followed situ decoration lanthanide-doped down-conversion nanoparticle (DCNP) shell SiO2, finally modifying it biocompatible polyethylene glycol (PEG), named AuNR@DCNP@PEG. Guided NIR-II FL/PA imaging, AuNR@DCNP@PEG was successfully irradiated at optimal enrichment time point, generating significant amount reactive oxygen species exhibiting excellent sensitization effects vitro vivo. This imaging-guided sensitizer is anticipated offer an approach achieving radiotherapy.

Language: Английский

Citations

0
Recent Developments in Near-Infrared-II Luminescence Imaging Using Inorganic Nanoparticles: Semiconductor Quantum Dots and Lanthanide Nanoparticles DOI
Jeong Geun Kim,

Hyeon Jung Yu,

Aeju Lee

et al.

Korean Journal of Chemical Engineering, Journal Year: 2024, Volume and Issue: 41(13), P. 3603 - 3619

Published: Oct. 23, 2024

Language: Английский

Citations

3
Automatic metabolism modulator for glycolytic intervention‐induced cascade cancer therapy DOI Creative Commons

Zheng Jiao,

Jian Zhang, Tian Zhang

et al.

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Effective intervention in glycolytic metabolism is a promising way to inhibit tumor malignant invasion. However, the inherent hypoxia environment and unitary regulating model subsequently compromise its therapeutic efficacy. Herein, facile design an automatic modulator (auto‐MMOD) developed by loading glucose oxidase (GOx) DNA‐templated silver nanoclusters (DNA‐AgNCs) into pH‐responsive zeolitic imidazolate frameworks‐8 (ZIF‐8) nanocarrier, which can activate cascaded metal ion‐killing effect during GOx‐regulated glycolysis metabolism. When acidic lysosome microenvironment induces ZIF‐8 decomposition, released GOx effectively consume generate H 2 O , thus inhibiting Adenosine Triphosphate synthesis accelerating starvation. Moreover, Ag + response disturb bioenergy proliferation, further enhances tumor‐killing hypoxic microenvironments. This study achieves effective suppression vitro vivo integrating ion therapy intervention, establish strategy for nano‐theranostics.

Language: Английский

Citations

2
Molecular Design of Nir-Ii Organic Fluorescent Probe Based on Adjusting the Shielding Unit DOI

Hua-chao Tian,

Minxia Liu,

Zi-long Cao

et al.

Published: Jan. 1, 2024

Organic fluorophores are extensively utilized in the second near-infrared window (NIR-II) for bioimaging applications, owing to their superior biocompatibility and favorable metabolic properties. This study focused on shielding unit-donor-acceptor-donor-shielding unit (S-D-A-D-S) architecture of organic π-conjugated molecules, which mitigates aggregation-induced quenching by modification terminal units. The introduction thiophene groups as donor units serves augment conjugation length, thereby inducing a redshift fluorescence wavelength with an increasing number Density functional theory (DFT) time-dependent DFT (TD-DFT) methods were employed investigate frontier molecular orbitals, electronic absorption, spectra designed compounds. An in-depth analysis elucidates mechanisms impact properties results indicate that phenoxazine group (POZ) linked at position 'a' provides most pronounced effect. Extending POZ-a compound extend within NIR-II spectrum, POZ-5 achieving up 1308 nm aqueous environment. Furthermore, modulating bridge's length enables precise control over compound's wavelength, luminescence intensity color purity, negligible from performance.

Language: Английский

Citations

0