Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Microneedle
patches
have
emerged
as
a
promising
approach
for
diabetic
wound
healing
by
enabling
the
targeted
delivery
of
therapeutic
agents
such
stem
cells
and
their
derived
exosomes,
well
localized
bioactive
moieties.
These
offer
non-invasive
efficient
method
administering
payloads
directly
to
site
wound,
bypassing
systemic
circulation
minimizing
potential
side
effects.
The
holds
immense
promoting
tissue
regeneration
accelerating
in
patients.
Similarly,
cell-derived
which
are
known
regenerative
anti-inflammatory
properties,
can
enhance
process.
Furthermore,
microneedle
enable
precise
controlled
release
moieties,
growth
factors
cytokines,
site,
creating
conducive
microenvironment
repair
regeneration.
challenges
associated
with
multifaceted.
Biocompatibility
issues,
variability
skin
characteristics
among
patients,
regulatory
hurdles,
scalability,
cost
considerations,
long-term
stability,
patient
acceptance
compliance
all
present
significant
barriers
widespread
adoption
optimization
technology
clinical
practice.
Overcoming
these
will
require
collaborative
efforts
from
various
stakeholders
advance
field
address
critical
gaps
research
development.
Ongoing
focuses
on
enhancing
biocompatibility
mechanical
properties
materials,
developing
customizable
technologies
personalized
treatment
approaches,
integrating
advanced
functionalities
sensors
real-time
monitoring,
improving
engagement
adherence
through
education
support
mechanisms.
advancements
improve
management
providing
tailored
therapies
that
promote
faster
reduce
complications.
This
review
explores
current
landscape
context
management,
highlighting
both
need
be
addressed
future
perspectives
this
innovative
modality.
Materials Futures,
Journal Year:
2025,
Volume and Issue:
4(2), P. 025402 - 025402
Published: April 23, 2025
Abstract
Microneedles
have
demonstrated
valuable
applications
in
diabetic
wound
management.
Many
endeavors
are
devoted
to
developing
microneedles
with
well-designed
structures
and
enhanced
functions.
Herein,
we
present
an
elaborate
microneedle
patch
breathability
for
healing
by
a
multi-step
replication
method.
The
consists
of
breathable
porous
supporting
substrate
core–shell
tips
involving
poly
(vinyl
alcohol)
shells
loaded
antimicrobial
peptides
(PVA@AMPs
shell)
crosslinked
Gelma
cores
encapsulated
exosomes
(Gelma@exo
core).
PVA
was
ROS-responsive
linker,
which
results
degradation
the
shell
inflammatory
microenvironment,
thus
inducing
release
AMPs
inhibit
bacteria.
Further,
continuously
from
exposed
Gelma@exo
core,
promoting
tissue
regeneration
regulating
immune
response.
Besides,
high
porosity
makes
patches
more
suitable
chronic
wounds.
Based
on
these
features,
it
that
exhibits
desirable
performance
vivo
animal
tests.
Thus,
believe
proposed
remarkable
potential
related
fields.
ABSTRACT
Diabetic
wounds
afflict
diabetic
patients
due
to
their
difficulty
in
healing
and
high
recurrence
rate.
The
complex
etiology
pathogenesis
of
chronic
wounds,
current
treatments
have
limitations
terms
suitability
efficacy,
making
it
difficult
achieve
the
desired
therapeutic
outcome
at
all
stages
disease,
leading
a
rate
recurrence.
Significant
progress
has
been
made
field
drug
delivery.
Microneedle
(MN)
based
transdermal
delivery
systems
emerged
as
new
solutions
Zhao's
group
developed
polymer
indwelling
MN
through
combined
manufacturing
strategy
involving
formwork
replication
3D
transfer
printing.
With
bionic
adaptability
exosome
encapsulation,
Benefiting
from
Hofmeister
effect,
mechanical
strength
PVA
hydrogel
exhibits
ion
responsiveness,
resulting
needle
tip
stiffness
matches
varying
tissue
strengths
strongly
ensure
skin
penetration
is
softened
by
nitrate
ions
accommodate
surrounding
after
tip‐base
separation
release
exosomes.
Furthermore,
envelope
MSC‐derived
exosomes,
tips
effectively
promote
function
fibroblasts,
endothelial
cells
vasculature,
macrophages
improve
wound
microenvironment
accelerate
repair
for
healing.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(44)
Published: Sept. 13, 2024
Abstract
Bioengineered
nerve
conduits
have
shown
great
promise
for
spinal
cord
injury
(SCI)
repair,
while
their
practical
values
are
limited
by
poor
regenerative
efficacy
and
lack
of
multi‐level
structural
design.
Here,
inspired
the
ingenious
anatomy
natural
cords,
a
biomimetic
multichannel
silk
conduit
(namely
BNC@MSCs/SCs)
with
multicellular
spatiotemporal
distributions
effective
SCI
repair
is
presented.
The
(BNC)
hierarchical
channels
aligned
pore
structures
prepared
via
modified
directional
freeze‐casting
strategy.
Such
provide
appropriate
space
mesenchymal
stem
cells
(MSCs)
Schwann
(SCs)
settled
in
specific
channels,
which
contributes
to
generation
BNC@MSCs/SCs
resembling
cellular
cords.
vitro
results
reveal
facilitated
SC
migration
MSC
differentiation
such
system,
further
promotes
tube
formation
cell
endothelial
as
well
M2
polarization
macrophages.
Moreover,
can
effectively
promote
tissue
function
recovery
rats
attenuating
glial
scar
promoting
neuron
regeneration
myelin
sheath
reconstruction.
Thus,
it
believed
that
valuable
other
neural
regeneration.
