Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 4270 - 4292

Published: July 1, 2024

Bone, a fundamental constituent of the human body, is vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present promising platform regeneration by mimicking native extracellular matrix architecture. Through optimized fabrication techniques incorporation active biomolecular components, NFMS precisely replicate nanostructure biochemical cues essential osteogenesis promotion. Furthermore, exhibit versatile properties, including tunable morphology, mechanical strength, controlled release kinetics, augmenting their suitability tailored engineering applications. enhance cell recruitment, attachment, proliferation, while promoting osteogenic differentiation mineralization, thereby accelerating healing. This review highlights engineering, elucidating design principles key attributes. By examining recent preclinical applications, we assess current clinical status discuss critical considerations potential translation. offers crucial insights researchers at intersection biomaterials highlighting developments this expanding field.

Language: Английский

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Pure and Doped Brushite Cements Loaded with Piroxicam for Prolonged and Constant Drug Release

Materials, Journal Year: 2025, Volume and Issue: 18(5), P. 1065 - 1065

Published: Feb. 27, 2025

The increase in life expectancy has led to a rise of musculoskeletal disorders. Calcium phosphate cements (CPCs), thanks some amazing features such as the ability harden vivo, bioactivity, and resorbability, are promising candidates treat these diseases, notwithstanding their poor mechanical properties. We aimed synthesise pure barium- or silicon-doped brushite-based CPCs loaded with piroxicam study effects substitution on physical-chemical pharmaceutical properties before after cement immersion buffer for different time periods. Our results demonstrated that became amorphous hardened cements. dopants did not change brushite structure its lamellar morphology, while both Ba Si additions improved initial Young's modulus compared cement, opposite trend was observed compressive strength. Both strength elastic decreased samples immersed solution non-immersed samples, stabilisation number days increased. After 7 days, whole drug amount released, slower constant kinetic Ba-doped Si-doped ones.

Language: Английский

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Hybrid Pectin-Fibroin Microgels with Supramolecular and Covalent Cross-Links

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Sugar beet pectin, an anionic polysaccharide, and silk fibroin, a high molecular weight protein, undergo gelation through ionic interactions conformational changes, leading to hydrogel formation. Although many studies have focused on bulk gel systems involving polysaccharides proteins, more research is needed investigate their properties at the microscale level. In this context, we developed microgel system based pectin/fibroin combination investigated its properties. We two mechanisms: physical cross-linking enzymatic covalent cross-linking. The microgels were fabricated using droplet-based microfluidics, secondary structure, mechanical properties, degradation profiles investigated. Our experimental results show that exhibit ordered β-sheet Young's modulus in range of 10 20 kPa, can be promoted protease enzymes. Finally, biocompatibility assessed Alamar Blue cell viability assay with human pulmonary fibroblasts (HPFs). This presents highly functional hybrid biomaterial produced from waste products structural demonstrating compatibility potential tissue engineering applications.

Language: Английский

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Bioactive vascular buds promote collateral vessel formation by grafting on the artificial vessel walls

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 564 - 575

Published: March 22, 2025

Language: Английский

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Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 979 - 979

Published: July 24, 2024

Intervertebral disc degeneration (IVDD) stands as the foremost contributor to low back pain (LBP), imposing a substantial weight on world economy. Traditional treatment modalities encompass both conservative approaches and surgical interventions; however, former falls short in halting IVDD progression, while latter carries inherent risks. Hence, quest for an efficacious method reverse onset is paramount. Biomaterial delivery systems, exemplified by hydrogels, microspheres, microneedles, renowned their exceptional biocompatibility, biodegradability, biological efficacy, mechanical attributes, have found widespread application bone, cartilage, various tissue engineering endeavors. Consequently, IVD has emerged burgeoning field of interest. This paper succinctly introduces intervertebral (IVD) structure pathophysiology IVDD, meticulously classifies biomaterials repair, reviews recent advances field. Particularly, strengths weaknesses are emphasized, potential avenues future research suggested.

Language: Английский

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Advances in photocrosslinked natural hydrogel‐based microspheres for bone repair

Journal of Polymer Science, Journal Year: 2024, Volume and Issue: 62(22), P. 4966 - 4992

Published: Aug. 9, 2024

Abstract In recent years, the prevalence of bone diseases is showing an increasing trend, which mainly attributed to aging global population. However, repair and regeneration are still unsolved problem in treatment diseases, include a series biological events. Photocrosslinked natural hydrogel‐based microspheres (PNHMs) spherical particles composed photocrosslinked hydrogel components. Due their morphology, injectability, biocompatibility, PNHMs widely used tissue regeneration, particularly for defects. this article, we review available materials PNHMs, then introduce preparation methods. After that, summarize important advanced functionalities PNHMs. For example, can be loaded with different active ingredients exert anti‐inflammatory, antibacterial, antioxidant effects, while also realizing lubrication due specific shape size distribution. addition, function capturing ions realized via coordination. When applied engineering, promote angiogenesis osteogenesis, great potential diseases. Finally, challenges prospects discussed.

Language: Английский

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Targeting Macrophages via Ultrasonic Contrast Microspheres for Monitoring and Treatment of Knee Synovitis

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Abstract The malignant cycle of synovitis considerably impacts the progression osteoarthritis (OA). Therefore, precise localization synovitis, targeted disruption inflammatory cycle, and real‐time monitoring its dynamics are crucial for effective diagnosis management OA. Here, porous HAMA/GelMA microspheres synthesized using microfluidic technology. Interleukin‐10 (IL‐10) nanobubbles, prepared via double emulsification, grafted with folic acid (FA) an amide reaction subsequently impregnated adsorbed onto microspheres, thereby constructing ultrasonic contrast microsphere system. This system facilitates not only imaging accurate but also controlled delivery IL‐10 under ultrasound conditions. In vitro, intensities 0, 0.5, 1.5 W, effectively releases at rates 19.95%, 30.95%, 40.67%, respectively. vivo, biodegradability tracking least 14 days. summary, enable synovitis. Under conditions, these drug delivery, disrupting vicious cycles. strategy pioneers new pathways treatment

Language: Английский

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Correction to “Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration”

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 6325 - 6331

Published: Aug. 20, 2024

Language: Английский

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Synergy of engineered gelatin methacrylate-based porous microspheres and multicellular assembly to promote osteogenesis and angiogenesis in bone tissue reconstruction

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137228 - 137228

Published: Nov. 1, 2024

Language: Английский

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