The Optimized Lipid‐Modified Prodrug for CNV Treatment

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Abstract Choroidal neovascularization (CNV) is a prevalent cause of vision impairment. The primary treatment for CNV involves intravitreal injections anti‐vascular endothelial growth factor antibodies. Nevertheless, this approach still faces numerous limitations like poor patient compliance, high therapy expenditure and lack response in some individuals. Herein, series anti‐neovascularization prodrugs, SU5402 (SU), modified with lipids varying chain lengths (C12, C16, C20, C24, C28) synthesized (SU‐C12, SU‐C16, SU‐C20, SU‐C24, SU‐C28). 1% polyvinyl alcohol (PVA) used as stabilizer to create nanoformulations five prodrugs named SU‐C12 NPs, SU‐C16 SU‐C20 SU‐C24 SU‐C28 NPs. Among these, NPs significantly prolong the retention bioactive drug eye up 70 d. Moreover, demonstrate superior tissue permeability via enhanced cellular endocytosis exocytosis. With its prolonged improved penetration, reduce fluorescence intensity fundus leakage by 42.5% area 51.5% mice after four weeks, effectively inhibiting progression CNV. Altogether, small molecule SU innovatively improve effectiveness treating neovascular diseases, proposing an alternative wet age‐related macular degeneration (wAMD).

Language: Английский

Mechanoimmunomodulation-based strategy on advancing tissue-engineered nanotopographic structures

Microstructures, Journal Year: 2025, Volume and Issue: 5(1)

Published: Feb. 14, 2025

The application of nanotopographic structures is considered a promising strategy for improving outcomes in tissue engineering. Nanotopographic structures-mediated immune responses have more profound influence than the direct modulation functional cell responses. However, reported immunomodulatory effects different are inconsistent and unpredictable. Therefore, it necessary to further understand general or fundamental biological mechanisms underlying regulation fabricate with desired properties. Compared on protein absorption physiochemical signals, mechanical forces induced by play pivotal role determining Elucidating mechanotransduction which from converted into intracellular biochemical signals cells crucial. This understanding essential precise mediated guiding development advanced review elucidates impact cellular subsequent activation mechanosensors. ensuing mechano-regulatory reviewed, mechanoimmunomodulation proposed as designing modulate immunity. contributes revolutionizing developing promotes mechanoimmunomodulatory property

Language: Английский