Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
97(1), P. 565 - 573
Published: Dec. 27, 2024
The
surge
of
lateral
flow
immunoassays
(LFAs)
stimulates
researchers
to
explore
the
novel
vibrant
aggregation-induced
emission
luminogen
(AIEgen)-doped
nanoparticles
improve
accuracy
and
reliability
LFAs.
However,
loading
amount
AIEgens
currently
used
for
LFA
in
microspheres
is
limited
due
their
symmetrical
large
conjugated
skeleton
structure,
which
significantly
reduces
fluorescence
brightness
signal
reporter
LFA.
Herein,
an
ionic
with
a
donor–acceptor
type
was
developed
as
C-reactive
protein
(CRP).
Ionic
are
unable
enter
hydrophobic
cavity
polystyrene
(PS)
because
low
nature.
By
altering
extended
alkyl
chains,
it
possible
increase
hydrophobicity,
thereby
potentially
increasing
capacity
within
PS.
Notably,
fluorescent
(denoted
AIETPANPs)
formed
by
embedding
(E)-4-(4-(diphenylamino)styryl)-1-octadecylpyridin-1-ium
iodide
(TPA)
PS
showed
orange-red
have
high
quantum
yield.
Anti-CRP
antibody
(mAb1)
could
be
effectively
surface
AIETPANPs
amino-carboxyl
reaction,
resulting
AIETPANPs-mAb1.
AIETPANPs-mAb1
exhibited
at
613
nm,
point
detectable
naked
eye
minimal
background
interference.
entire
analysis
accomplished
just
10
min,
achieving
limit
detection
4.06
ng/mL
CRP.
AIETPANPs-mAb1-based
demonstrates
excellent
stability
specificity
fully
meets
requirements
clinical
diagnosis.
Biomacromolecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 24, 2025
High
levels
of
reactive
oxygen
species
(ROS)
and
hypoxia
in
diabetic
wounds
significantly
hinder
the
healing
process.
In
this
work,
a
kind
catalase-like
nanozyme-hybrid
hydrogel
was
developed
to
explore
potential
harnessing
endogenous
excessive
ROS
as
an
source
synergistically
regulate
oxidative
stress
hypoxia,
thereby
enhancing
wound
healing.
The
hydrogels
exhibited
rapid
degradation
controlled
release
ferrihydrite
nanozymes
response
stress,
which
continuously
catalyzed
decomposition
H2O2
generate
oxygen,
effectively
scavenging
reducing
risk
local
toxicity.
relieved
intracellular
hypoxic
microenvironment
simultaneously
vitro.
dressings
inhibited
damage
at
sites,
promoted
epidermis
formation
collagen
deposition,
accelerated
db/db
mice.
Therefore,
represent
promising
strategy
for
dressings,
addressing
both
improve
outcomes.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(26), P. 10686 - 10695
Published: June 17, 2024
Exploiting
the
multiple
properties
of
nanozymes
for
multimode
lateral
flow
assay
(LFA)
is
urgently
required
to
improve
accuracy
and
versatility.
Herein,
we
developed
a
novel
plasmonic
Au
nanostar@PtOs
nanocluster
(Au@PtOs)
as
signal
tag
LFA
detection.
Based
on
PtOs
bimetallic
doping
strategy,
Au@PtOs
can
indicate
both
excellent
SERS
enhancement
nanozyme
catalytic
activity.
Meanwhile,
displays
better
photothermal
effect
than
that
nanostars.
Therefore,
colorimetric/SERS/temperature
three-mode
signals
be
read
out
based
nanocomposite.
The
was
combined
with
applied
breast
cancer
exosome
detection
limit
mode
2.6
×
103/4.1
101/4.6
102
exosomes/μL,
respectively,
which
much
superior
common
nanoparticles
(∼105
exosomes/μL).
Moreover,
fingerprint
molecular
recognition
ability
mode,
phenotypes
derived
from
different
cell
lines
discriminated
easily.
convenient
visual
colorimetric
sensitive
SERS/temperature
quantitative
modes,
driven
satisfy
requirements
accurate
flexible
multimodal
sensing
in
application
scenarios.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Dual
atomic
nanozymes
(DAzymes)
are
promising
for
applications
in
the
field
of
tumor
catalytic
therapy.
Here,
integrating
with
ultrasmall
Fe5C2
nanoclusters,
asymmetric
coordination
featuring
Janus
Zn-Fe
dual-atom
sites
an
O2N2-Fe-Zn-N4
moiety
embedded
a
carbon
vacancy-engineered
hollow
nanobox
(Janus
ZnFe
DAs-Fe5C2)
was
elaborately
developed.
Theoretical
calculation
revealed
that
synergistic
effects
Zn
centers
acting
as
both
adsorption
and
active
sites,
oxygen-heteroatom
doping,
vacancy,
nanoclusters
jointly
downshifted
d-band
center
Fe
3d
orbitals,
optimizing
desorption
behaviors
intermediates
*OH,
thereby
significantly
promoting
activity.
Upon
1064
nm
laser
irradiation,
DAs-Fe5C2
superior
photothermal
conversion
efficiency
(η
=
62.5%)
showed
thermal-augmented
Fascinatingly,
multienzymatic
properties
can
suppress
expression
glutathione
peroxidase
4
accelerate
accumulation
lipid
peroxides,
through
which
ferroptosis
is
triggered.
Overall,
tannin-involved
will
inspire
more
inventions
biodegradable
DAzymes
therapy
application.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Abstract
The
local
electron
distribution
at
active
sites
is
one
of
the
key
determinants
to
affect
catalytic
activity
for
hydroxyl
radicals
(·OH)
generation
from
endogenous
hydrogen
peroxide
(H
2
O
)
boost
chemodynamic
therapy
(CDT)
efficiency.
Herein,
carbon‐coated
NiFe
4
nanocatalysts
(NFN@C)
with
localized
octahedral
Fe
induced
by
dopant
Ni
into
spinel
structure
designed
significantly
enhance
CDT
configuration
promotes
·OH
adsorption,
intensifying
its
Fenton
reaction
activity.
Moreover,
incorporation
endows
NFN@C
exceptional
efficacy
in
near‐infrared
II
(NIR‐II)
mediated
photothermal
(PTT),
amplifying
cancer‐fighting
potential.
Rigorous
In
Vitro
and
Vivo
analyses
highlight
unmatched
capability
tumor
ablation
through
combined
PTT
modalities.
This
work
presents
a
potent
strategy
adjusting
sites,
thereby
enhancing
NIR‐II
responsive
magnetic
enabling
multifunctional
therapeutic
applications.
