Enhancing immunotherapy using a synergistic T-lymphocyte and neutrophil-targeting activation (TNTa) strategy for triple-negative breast cancer treatment DOI
Li Zhang, Huajian Chen,

Zhouyue Jiang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 159096 - 159096

Published: Dec. 1, 2024

Language: Английский

PD-L1 peptides in cancer immunoimaging and immunotherapy DOI

Shiye Du,

Junzhi Liu,

Youjia Zhang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 378, P. 1061 - 1079

Published: Jan. 5, 2025

Language: Английский

Citations

2
Peptide nanozymes: An emerging direction for functional enzyme mimics DOI
Shao‐Bin He,

Long Ma,

Qionghua Zheng

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 42, P. 284 - 298

Published: Sept. 4, 2024

Language: Английский

Citations

12
New horizons for the therapeutic application of nanozymes in cancer treatment DOI Creative Commons
Pravanjan Malla, Yu‐Ming Wang, Chia‐Hao Su

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 20, 2025

The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes

Language: Английский

Citations

1
Mucin-Triggered Osmium Nanoclusters as Protein-Corona-Like Nanozymes with Photothermal-Enhanced Peroxidase-Like Activity for Tumor-Specific Therapy DOI
Shao‐Bin He,

Qionghua Zheng,

Long Ma

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(45), P. 14337 - 14345

Published: Oct. 29, 2024

Nanomaterials with peroxidase-like activity and photothermal conversion efficiency have garnered significant attention for their ability to generate cytotoxic hydroxyl radicals provide synergistic therapeutic effects. Selecting nanozymes suitable properties carriers is crucial maximizing efficacy. While the mucin family known its mucoadhesive, glycosylated structures that enhance drug bioavailability targeting, potential in remains underexplored. Here, we utilize mucin-2 facilitate osmium nanoclusters (Os@Mucin), creating protein-corona-like nanozymes. This configuration bestows Os@Mucin excellent (769 U/mg) (22.83%, 808 nm). Mucin-2 promotes Os uptake by cells, allowing exhibit tumor environment-responsive activity, further enhanced under conditions targeted cytotoxicity

Language: Английский

Citations

4
Study on the regulatory mechanisms of mitochondrial biosynthesis by polyoxometalates DOI Creative Commons
Lei Shan,

Bingnian Chen,

Li Wang

et al.

Polyoxometalates, Journal Year: 2025, Volume and Issue: 4(1), P. 9140074 - 9140074

Published: March 1, 2025

In recent years, polyoxometalates have been systematically studied in the treatment of diabetes, tumor, cancer, inflammation and other diseases vitro vivo, their main therapeutic mechanisms are related to generation reactive oxygen species causing oxidative stress. The site production is mitochondria, therefore, mechanism may be mitochondrial biosynthesis. This paper describes one diabetes mellitus, which involves increase species, resulting stress; at same time, preliminarily as antioxidants antitumor mellitus tumors, antioxidant properties provide an additional possibility for future a drug disease treatment; on basis study stress biomolecule due it, associating therapy actually closely through biosynthesis regulation relationship between mitochondria its impact three aspects order in-depth role drugs aspects.

Language: Английский

Citations

0
Carbon-based nanozymes for cancer therapy and diagnosis: A review DOI Creative Commons
Marco Cordani, Jesús Fernández‐Lucas, Arezoo Khosravi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139704 - 139704

Published: Jan. 1, 2025

Language: Английский

Citations

0
Enhanced cGAS‐STING Activation and Immune Response by LPDAM Platform‐Based Lapachone–Chemical–Photothermal Synergistic Therapy for Colorectal Cancer DOI Open Access
Xiaoyu Pan,

Yan Lin,

Chunlin Lin

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract The cGAS‐STING signaling pathway is a pivotal immune response mechanism that bridges tumor and cell interactions. This study describes multifunctional LPDAM nanoplatform integrating Lapachone, polydopamine (PDA), Mn 2+ , which synergistically kills cells activates the pathway, thereby inducing DC maturation T activation to achieve potent antitumor immunity. In microenvironment, Lapachone generates H 2 O via NAD(P)H:quinone oxidoreductase 1 (NQO1 enzyme), while catalyze conversion into •OH through chemodynamic effects (CDT). photothermal (PTT) of PDA further amplify this cascade reaction, producing reactive oxygen species (ROS) damage mitochondria release mitochondrial DNA (mtDNA). released mtDNA enhances sensitivity cGAS mtDNA, leading robust Concurrently, photothermal‐induced immunogenic death (ICD) promotes d endritic ( DCs) maturation, strengthening responses. Moreover, ⁺ also serves as contrast agent for T1‐weighted magnetic resonance imaging (MRI), offering precise visualization. demonstrates facilitates Lapachone/CDT/PTT synergistic therapy under MRI guidance, showcasing its potential an innovative strategy combined immunotherapy in clinical oncology.

Language: Английский

Citations

0
Manganese-coordinated nanoparticles loaded with CHK1 inhibitor dually activate cGAS-STING pathway and enhance efficacy of immune checkpoint therapy DOI
Rui Huang, Yijia Wu, Feiyang Shen

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123199 - 123199

Published: Feb. 20, 2025

Language: Английский

Citations

0
Bimetallic nanozymes for effectively removing Enterococcus faecalis biofilms in pulp and periapical infection treatment DOI
You‐Lin Qiao, Yanfeng Shi,

Mengyu Jiao

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 681, P. 148 - 158

Published: Nov. 23, 2024

Language: Английский

Citations

1
Enhancing immunotherapy using a synergistic T-lymphocyte and neutrophil-targeting activation (TNTa) strategy for triple-negative breast cancer treatment DOI
Li Zhang, Huajian Chen,

Zhouyue Jiang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 159096 - 159096

Published: Dec. 1, 2024

Language: Английский

Citations

1