As Aggregation‐Induced Emission Meets with Noncovalent Conformational Locks: Subtly Regulating NIR‐II Molecules for Multimodal Imaging‐Navigated Synergistic Therapies DOI
Jiangao Li,

Niu Niu,

Deliang Wang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 137(1)

Published: Sept. 21, 2024

Abstract Phototheranostics is growing into a sparking frontier in disease treatment. Developing single molecular species synchronously featured by powerful absorption capacity, superior second near‐infrared (NIR‐II) fluorescence and prominent photothermal conversion ability highly desirable for phototheranostics, yet remains formidably challenging. In this work, we propose design philosophy that the integration of noncovalent conformational locks (NoCLs) with aggregation‐induced emission (AIE) formulation able to boost multiple photophysical properties efficient phototheranostics. The introduction NoCLs skeleton conformation‐locking feature center architecture indeed elevates structural planarity rigidity, which simultaneously promotes capacity bathochromic‐shifts wavelength centered NIR‐II region. Meanwhile, AIE tendency mainly originated from flexibly propeller‐like geometry at ends eventually endows molecule satisfactory intensity aggregates. Consequently, utilizing optimized molecule, unprecedented performance on fluorescence‐photoacoustic‐photothermal trimodal imaging‐guided photothermal‐chemo synergistic therapy demonstrated precise tumor diagnosis complete ablation.

Language: Английский

As Aggregation‐Induced Emission Meets with Noncovalent Conformational Locks: Subtly Regulating NIR‐II Molecules for Multimodal Imaging‐Navigated Synergistic Therapies DOI
Jiangao Li,

Niu Niu,

Deliang Wang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 137(1)

Published: Sept. 21, 2024

Abstract Phototheranostics is growing into a sparking frontier in disease treatment. Developing single molecular species synchronously featured by powerful absorption capacity, superior second near‐infrared (NIR‐II) fluorescence and prominent photothermal conversion ability highly desirable for phototheranostics, yet remains formidably challenging. In this work, we propose design philosophy that the integration of noncovalent conformational locks (NoCLs) with aggregation‐induced emission (AIE) formulation able to boost multiple photophysical properties efficient phototheranostics. The introduction NoCLs skeleton conformation‐locking feature center architecture indeed elevates structural planarity rigidity, which simultaneously promotes capacity bathochromic‐shifts wavelength centered NIR‐II region. Meanwhile, AIE tendency mainly originated from flexibly propeller‐like geometry at ends eventually endows molecule satisfactory intensity aggregates. Consequently, utilizing optimized molecule, unprecedented performance on fluorescence‐photoacoustic‐photothermal trimodal imaging‐guided photothermal‐chemo synergistic therapy demonstrated precise tumor diagnosis complete ablation.

Language: Английский

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