Ascorbate-loaded Mg Fe layered double hydroxide for osteomyelitis treatment

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 378, P. 1045 - 1060

Published: Jan. 5, 2025

Language: Английский

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Engineering Hierarchically Grooved Structures for Enhancing Interfacial Solar Thermal Water Purification

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Inclined interfacial solar evaporators, especially those based on microgrooved Al substrates, show great potential for application in water purification to alleviate the crisis. However, performance degradation caused by corrosion and contamination seriously affects their service life. To address this issue, a renewable heterojunction with TiO2 as inner layer ZnO outer is formed atomic deposition, which provides effective anticorrosion protection efficiently kills adhered planktonic bacteria. It also generates abundant photoinduced reactive oxide species degrade organic pollutants improves evaporation rate enhancing wicking photothermal conversion. Moreover, photodegradation −OH regeneration properties of endow substrates prolonged This work practical strategy improve inclined evaporators purify polluted water.

Language: Английский

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Inverse Oxide/Alloy‐Structured Nanozymes with NIR‐Triggered Enzymatic Cascade Regulation of ROS Homeostasis for Efficient Wound Healing

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

The precise spatiotemporal control of reactive oxygen species (ROS) generation and scavenging remains pivotal for infected wound healing. However, conventional nanozymes fail to adaptively regulate ROS dynamics across inflammatory proliferative phases. A near-infrared (NIR)-activated inverse oxide/alloy-structured nanozyme (Co7Fe3/ZnO@C) is developed, featuring enzymatic cascade activities tune homeostasis through synergistic chemodynamic (CDT), photodynamic (PDT), photothermal (PTT) therapies. orchestrates a self-regulated cascade: peroxidase (POD)-like activity initially generates bactericidal hydroxyl radicals in acidic wounds, while subsequent NIR triggers hot electron transfer from Co7Fe3 ZnO, facilitating synchronized superoxide dismutase (SOD)-like, catalase (CAT)-like radical antioxidant capacity (HORAC) scavenge residual ROS. This cascaded network dynamically balances production (POD) (NIR-driven SOD/CAT/HORAC), eradicating bacteria resolving inflammation. In vitro/vivo studies have shown that the proposed method maintaining can markedly enhance rate healing by regulation environment within injured tissue facilitation rapid re-epithelialization. work provides an intelligent platform simulates function natural enzymes constructs reaction strategy balance antibacterial anti-inflammatory demands microenvironment.

Language: Английский

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Interfering with proton and electron transfer enables antibacterial starvation therapy

Science Advances, Journal Year: 2025, Volume and Issue: 11(12)

Published: March 19, 2025

Implant-associated infections are urgently addressed; however, existing materials difficult to kill bacteria without damaging cells. Here, we propose an innovative concept of selective antibacterial starvation therapy based on interfering with proton and electron transfer the bacterial membrane. As a proof-of-principle demonstration, special Schottky heterojunction film composed gold alkaline magnesium-iron mixed metal oxides (Au/MgFe-MMO) was constructed titanium implant. Once contacted this implant, Au/MgFe-MMO continuously captured participated in respiratory chain impede their energy metabolism, leading deficit adenosine 5′-triphosphate. Prolonged exposure state inhibited numerous biosynthesis processes triggered severe oxidative stress bacteria, ultimately death due DNA membrane damage. In addition, comfortable for mammalian cells, inhibiting mitochondrial function. This proposed gives notable perspective designing biosafe smart biomaterials.

Language: Английский

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A Dual‐Catalysis Mode for ROS Regulation to Accelerate Biointegration of Implants in Infected Diabetic Wound

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Pathological microenvironment of diabetes including hyperglycemia, excessive reactive oxygen species (ROS), and accumulation advanced glycation end products leads to high risk infection persistent inflammatory reaction, retarding biointegration implants. To address this issue, a dual‐catalysis system consisting Na 2 TiO 3 nanotubes with CeO nanodots polydopamine (PDA) cover is constructed on Ti implant manipulate ROS generation scavenging for antibiosis tissue regeneration. form heterojunction, in which vacancies (VOs) contribute the separation electron‐hole pairs under near‐infrared light (NIR) irradiation. In NIR mode, photocatalysis‐induced photothermal‐induced hyperthermia by ‐CeO heterojunction PDA synergistically kill bacteria efficiently. non‐NIR show excellent superoxide dismutase (SOD) catalases (CAT) like enzyme activities, they catalyze (e.g., ·O − H O ) thoroughly into benign O, relieving oxidative stress accelerating M2 macrophage phenotype. It helps biofunctional recovery endothelial cells fibroblasts, promoting regeneration around implants diabetic models. This work proposes promising approach manipulating treat regulate thereby improving performance microenvironment.

Language: Английский

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A Targeted Core–Shell ZIF-8/Au@Fe₃O₄ Platform with Multiple Antibacterial Pathways for Infected Skin Wound Regeneration

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Bacterial infections seriously retard skin wound healing. To enhance the antibacterial efficiency and subsequent regeneration, a core-shell structured therapeutic platform, named FZAM, was designed with multiple antimicrobial pathways. FZAM consists of nanosized Fe3O4 as core ZIF-8 loaded Au nanoparticles (NPs) maltodextrin shell. NPs form heterojunction that generates hyperthermia abundant reactive oxide species (ROS) under near-infrared (NIR) irradiation. This also exhibits outstanding peroxidase-like activity. When bacteria invade, plays targeting effect to increase interaction between bacteria, synergistic action NIR-induced ROS well Zn2+ from ZIF-8, kills more than 99% at 200 μg mL-1. Fortunately, is cytocompatible even promotes biofunctions fibroblasts endothelial cells. In infected models, sterilizes NIR irradiation subsequently reduces inflammatory response accelerates regeneration. work provides therapy platform for treating infection assistance helping

Language: Английский

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“Thermal bubbles”: Photothermally triggered by a carbon monoxide nanocontainer for antibiosis and immune modulation therapy

Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102758 - 102758

Published: April 14, 2025

Language: Английский

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Advances in metallic biomaterial-based osteomyelitis theranostics

Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 8(1)

Published: Nov. 29, 2024

Language: Английский

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Functionalized Bone Implant Inspired by Lattice Defense Strategy: Grid Management, Precise and Effective Multiple‐Prevention of Osteomyelitis Recurrence and Promote Bone Regeneration

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Osteomyelitis with a high recurrence rate. Timely-prevention can avoid severe consequence and death. However, conventional drug response-release has the disadvantages of unnecessary release waste, causing ineffective prevention. Inspired by "Lattice-defense technology", gridding lesion areas constructing "Triggered-precise system" may be an effective multiple-prevention method. Here, new strict pH-triggered response controlled-release mechanism was proposed innovatively to construct achieve multiple-effective PO

Language: Английский

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